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A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins–Ritter amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM). [ABSTRACT FROM AUTHOR]

2-Amino-5-hydroxypropiophenone, a key precursor in the total synthesis of irinotecan, has been synthesized. Regioselective nitration and a SNAr displacement are the key steps involved in this strategy, which is high yielding, is economical, and has been performed on a plant scale. Supplemental materials are available for this article. Go to the publisher's online edition ofSynthetic Communications® to view the free supplemental file. [ABSTRACT FROM PUBLISHER]

β-Enamino derivatives have been synthesized by the condensation of amines and β-dicarbonyl compounds in the presence of 1 mol% of phosphomolybdic acid (PMA) at room temperature in good to excellent yields. [ABSTRACT FROM PUBLISHER]

[image omitted] A simple and efficient method for multicomponant synthesis of 3,4-dihydropyrimidinones has been reported. All the reactions were carried out using samarium triflate as catalyst (10 mol%) at acetonitrile reflux. This procedure is applicable to a variety of substrates such as aliphatic, aromatic, and heterocyclic aldehydes. [ABSTRACT FROM AUTHOR]

[image omitted] Trimethylsilyl iodide (TMSI) was found to be an efficient catalyst for the vinylogous Mukaiyama aldol reaction of 2-(trimethylsilyloxy)furan with various aldehydes with good diastereoselection. The reaction proceeds rapidly in CH2Cl2 affording the corresponding 5-(hydroxy(aryl)methyl)furan-2(5H)-ones in good yields. This method offers significant advantages such as efficiency, generality, and mild reaction conditions with shorter reaction time. [ABSTRACT FROM AUTHOR]

One-pot synthesis of benzimidazole compounds from ortho-phenylenediamine and a variety of aldehydes was developed under mild reaction conditions. All the reactions were carried out in the presence of samarium triflate (10 mol%) in acetonitrile at room temperature. [ABSTRACT FROM AUTHOR]

A simple and efficient one-pot synthesis of symmetrical 4-amido tetrahydropyrans via the Sakurai-Prins-Ritter reaction sequence using molecular iodine as catalyst from an aldehyde and allyltrimethylsilane in acetonitrile is described. This new method has the advantage of good to excellent yields (60-98%) and short reaction times (20-150 min) at ambient temperature with high diastereoselectivity. [ABSTRACT FROM AUTHOR]

Perchloric acid adsorbed on silica gel efficiently catalyzed the condensation of o-phenylenediamines (OPDA) with cyclic and acyclic ketones at ambient temperature to afford 1,5-benzodiazepines in good yields under solvent-free conditions. [ABSTRACT FROM AUTHOR]

Asymmetric total synthesis of the sex pheromones of Japanese beetle and currant stem girdler, (R)-japonilure (1) and (4R,9Z)-9-octadecen-4-olide (2), has been achieved. [ABSTRACT FROM AUTHOR]

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (3) as chiral material, (R)-(-)-rhododendrol 2, the aglycone of the naturally occurring rhododendrin 1 was synthesized. [ABSTRACT FROM AUTHOR]

A general synthetic approach to both enantiomers, (R)- and (S)-massoialactones, has been devised from commercially available (S)-butane-1,2,4-triol. [ABSTRACT FROM AUTHOR]

Stereoselective total synthesis of two chiral lactones, (+)-trans-cognac lactone (1b) and (+)-trans-aerangis lactone (2c), has been achieved from the same intermediate using a radical-based cyclization route. [ABSTRACT FROM AUTHOR]

A simple and efficient method of zinc dust-mediated N-sulfonylation of amines to the corresponding sulfonamides is described. The reaction is carried out under neutral and mild conditions. The significant feature of this method is the isolation of the pure product by simple work up in a short time. [ABSTRACT FROM AUTHOR]

The imines were generated in situ from carbonyl compounds and amines, which undergo smooth reduction with sodium borohydride in an ionic liquid/H2O solvent system. The reaction conditions were very mild and neutral to afford the corresponding highly functionalized amines in excellent yields.IICT Communication No. 041013. [ABSTRACT FROM AUTHOR]

Intramolecular cyclization of ortho-allylphenols has been carried out using zirconium (IV) chloride in mild condition. This method avoids the use of expensive reagents and leads to highly functionalized dihydrobenzofurans. [ABSTRACT FROM AUTHOR]

The cross-coupling reaction of homoallyl alcohols with aldehydes in the presence of bismuth trichloride in solvent-free conditions generated 4-chloro-2,6-disubstituted tetrahydropyrans in high yields with high diastereoselectivity. Improved yields and reduced reaction times are achieved in this transformation by employing microwave irradiation. [ABSTRACT FROM AUTHOR]

Aldehydes are chemoselectively converted into the corresponding gem-diacetates at ambient temperature in high to quantitative yields using a catalytic amount of indium (III) chloride. The deprotection of the resulting gem-diacetates is achieved using the same catalyst in the presence of water. [ABSTRACT FROM AUTHOR]

Aromatic aldehydes undergo cross-aldol condensation with ketones in the presence of KF-Al2O3 under microwave irradiation in solvent-free conditions to afford the corresponding α,α′-bis(benzylidene) alkanones in high yields. [ABSTRACT FROM AUTHOR]

Several aldehydes and ketones were efficiently converted into their corresponding dithioacetals and 1,3-dithianes in high yields using catalytic amount of indium(III) chloride in dichloromethane. [ABSTRACT FROM AUTHOR]

Iron(III) catalyses efficiently an unusual cyclocondensation of o-hydroxybenzaldehydes with 2,2-dimethoxypropane at ambient temperature to produce 2,4-dimethoxy-2-methyl-2H-1-benzopyrans in high yields with high diastereoselectivity. Also, it catalyses the formation of benzopyran derivatives from o-hydroxybenzaldehydes, acetone and trimethyl orthoformate. [ABSTRACT FROM AUTHOR]

Benylic, allylic, and propargylic alcohols, as well as diols, can be oxidized with o-iodoxybenzoic acid (IBX) in the presence of stabilized Wittig ylide to generate α,β-unsaturated ester in one pot. This is useful when the intermediate aldehydes are unstable and difficult to isolate. *IICT communication no. 4369. [ABSTRACT FROM AUTHOR]

Bismuth (III) chloride effectively catalyzes aza-Diels-Alder reaction of N-aryl aldimines with nucleophilic olefins for the first time to afford quinoline derivatives in high yields at ambient temperature.*IICT Communication No. 4499. [ABSTRACT FROM AUTHOR]

gem-Diacetates are selectively deprotected to the corresponding aldehydes in high yields by CBr4 in refluxing acetonitrile under neutral reaction conditions.*IICT Communication No. 4491. [ABSTRACT FROM AUTHOR]