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We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senescence, while its overexpression allows cells to bypass oncogene-induced senescence. Elevated ZNF768 levels is common in tumors, suggesting that ZNF768 may help to escape cellular senescence, sustain proliferation and promote malignant transformation. Here, we discuss these recent findings and highlight key questions emerging from our work. [ABSTRACT FROM AUTHOR]

The aims of this study are to investigate the production of activated carbons (AC) from Senegal agricultural wastes such as cashew shells, millet stalks and rice husks and to implement them in adsorption processes devoted to arsenic (V) removal. AC were produced by a direct physical activation with water steam without other chemicals. This production of AC has also led to co-products (gas and bio-oil) which have been characterized in terms of physical, chemical and thermodynamical properties for energy recovery. Considering the arsenic adsorption results and the energy balance for the three studied biomasses, the first results have shown that the millet stalks seem to be more interesting for arsenate removal from natural water and an energy recovery with a GEEelecof 18.9%. Cashew shells, which have shown the best energy recovery (34.3%), are not suitable for arsenate removal. This global approach is original and contributes to a recycling of biowastes with a joint recovery of energy and material. [ABSTRACT FROM PUBLISHER]

Objectives: Persistent genital arousal disorder (PGAD) is a rare condition. Our aim was to study whether or not the pudendal nerve is involved in PGAD, by means of electromyographic (EMG) testing. Methods: Twenty-three women who fulfilled the five criteria of PGAD were included in this study. After an in-depth interview and routine investigations, a perineal EMG assessment was performed. Concentric needle electromyography (EMG) testing with motor unit potential analysis of the pelvic floor muscles (bulbocavernosus muscle and striated external anal sphincter), study of the sacral reflex latency (SRL), and measurement of pudendal nerve terminal motor latency (PNTML) were performed. Results: Perineal ENMG demonstrated neurogenic changes in 14 (60.8%) of the patients. Denervation was found in all 14 patients with abnormal electrophysiological findings. Among them, 12 (85.7%) had altered PTNML and/or SRL. PTNML was delayed on the anal branch in 9 out of 14 (bilateral in 5 cases) and on the perineal branch in 9 out of 14 (bilateral in 6 cases). Conclusions: This study shows that pudendal neuropathy is frequent among women suffering from PGAD. However, due to the lack of a control group, involvement of pudendal neuropathy in the pathogenesis of PGAD remains unclear. [ABSTRACT FROM AUTHOR]