1. Anti-inflammatory constituents from Psychotria prainii H. Lév.
- Author
-
Tran, Phi Hung, Le, Viet Dung, Do, Thi Ha, Nguyen, Thi Luyen, Nguyen, Phuong Thao, Nguyen, Trong Thong, and Nguyen, Tien Dat
- Abstract
One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC
50 values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF