1. Maternal and fetal thiol/disulfide homeostasis in fetal growth restriction.
- Author
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Eroglu, Hasan, Turgal, Mert, Senat, Almila, Karakoc, Gokhan, Neselioglu, Salim, and Yucel, Aykan
- Subjects
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FETAL growth retardation , *HOMEOSTASIS , *CORD blood , *CONFIDENCE intervals , *GESTATIONAL age , *FETAL distress , *FETAL macrosomia , *SULFUR compounds , *CASE-control method , *QUESTIONNAIRES , *LONGITUDINAL method - Abstract
Purpose: To evaluate thiol/disulfide homeostasis in both maternal and fetal compartment in the presence of fetal growth restriction (FGR).Materials and Methods: A prospective case-control study was carried out in women with FGR (n: 40) or normally growing fetus (n: 40). FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Maternal serum and fetal cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance.Results: Native thiol, total thiol and disulfide amounts were decreased in the maternal serum and fetal cord blood of babies born to women with FGR (pā<ā.05). The most sensitive marker was maternal native thiol (82.5, 95% confidence interval, 67.22-92.66%), while the maternal total thiol had highest specificity value (77.5, 95% confidence interval, 61.55-89.16%).Conclusions: Maternal and fetal serum thiol/disulfide profiles may use prediction of FGR severity and its neonatal outcome. [ABSTRACT FROM AUTHOR]- Published
- 2021
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