Search

Extramedullary hematopoiesis (EMH) in individuals with thalassemia is often the result of undertreated severe anemia. Radiation or surgery is often the chosen approach to handle spinal cord compression due to these paraspinal EMH elements. Our patient is a 28-year-old male with E-beta-thalassemia who presented with both upper thoracic and lower extremity symptoms of spinal cord compression and was successfully managed with the combination of transfusion and hydroxyurea. Given the variation in symptoms as a result of the sporadic location as well as the extent of these EMH elements along the spinal canal, the hematological communities will continue to benefit from case reports that offer treatment therapy. [ABSTRACT FROM AUTHOR]

Introduction:Symptomatic metastatic spinal disease is on the increase. Minimally invasive spinal surgery has been associated with a lower complication profile when compared to traditional open methods; however there is paucity of literature evaluating the place of percutaneous pedicle screw fixation (PPSF) in the management of spinal metastases. The purpose of the study is to assess the efficacy of Minimally Invasive Spine Surgery (MISS) using PPSF with or without mini-decompression in the management of symptomatic spinal metastases. Material and Methods:This is a single institution prospective study of 51 consecutive patients with metastatic spinal disease treated with PPSF. Patients presenting with pathological compression fractures and mechanical instability had PPSF, and those with radiological and/or clinical metastatic spinal cord compression (MSCC) underwent an additional mini-decompression. Data collected included patient demographics, Karnofsky’s performance status (KPS), pain scores and neurology. Other data included number and location of involved levels, number of instrumented levels, blood loss, accuracy of screw placement and complications. Results:Of the 51 patients, 49 could be successfully treated with MISS (26 females and 23 males). 26 patients (55%) required a mini-decompression. 27 patients (55%) had improvement in KPS by at least 10 points (p < 0.0005). Only 2 patients (4%) had a worsening of KPS, due to other coexisting problems. Six of the 13 patients improved their neurology by one Frankel grade following surgery and 95% reported improvement in pain. Mean blood loss was 92mls for the fixation only group and 222mls for those requiring mini-decompression, with no other differences between these two surgical groups. Screw positioning was excellent in 91%, with 98% having uncompromised bony hold. Only two patients required revision surgery for aseptic loosening. Conclusion:MISS using PPSF is a safe and reproducible technique that maintains or improves functional outcome in the vast majority of patients presenting with spinal metastases. [ABSTRACT FROM PUBLISHER]

Secondary damage after acute spinal cord compression injury (SCCI) exacerbates initial insult. Nuclear factor kappa-B (NF-κB)-p65 activation is involved in SCCI deleterious effects. Agmatine (Agm) showed neuroprotection against various CNS injuries. However, Agm impact on NF-κB signaling in acute SCCI remains to be investigated. The present study compared the effectiveness of Agm therapy and decompression laminectomy (DL) in functional recovery, oxidative stress, inflammatory and apoptotic responses, and modulation of NF-κB activation in acute SCCI rat model. Rats were either sham-operated or subjected to SCCI at T8–9, using 2-Fr. catheter. SCCI rats were randomly treated with DL at T8–9, intraperitoneal Agm (100 mg/kg/day), combined (DL/Agm) treatment or saline ( n = 16/group). After 28-days of neurological follow-up, spinal cords were either subjected to biochemical measurement of oxidative stress and inflammatory markers or histopathology and immuno-histochemistry for NF-κB-p65 and caspase-3 expression ( n = 8/group). Agm was comparable to DL in facilitating neurological functions recovery, reducing inflammation (TNF-α/interleukin-6), and apoptosis. Agm was distinctive in combating oxidative stress. Agm neuroprotective effects were paralleled with inhibition of NF-κB-p65 nuclear translocation. Combined pharmacological and surgical interventions were proved superior in functional recovery. In conclusion, present research suggested a new mechanism for Agm neuroprotection in rats SCCI through inhibition of NF-κB activation. [ABSTRACT FROM AUTHOR]

An abstract of the article "Patient Positioning (Mobilisation) and Bracing for Pain Relief and Spinal Stability in Metastatic Spinal Cord Compression in Adults" by S. H. Lee et al. is presented.