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In the present study, headspace gas chromatography coupled with mass spectrometry (HS–GC/MS) was applied to profile volatile components of Bunium persicum samples (rhizomes, roots, stems, leaves, flowers and unripe & ripe seeds), which were collected from two locations of Indian alpine Himalaya. Thirty-six different volatile metabolites were characterized in all samples, representing (77.9-96.9%) of the total oils. Extracted volatile oils (VOs) were dominated by monoterpenes (37.9-94.8%), oxygenated monoterpenes (0.1-28.8%) and sesquiterpenes (0.2-24.3%) hydrocarbons. γ-Terpinene (6.0-64.1%), α-terpinolene (1.1-43.7%), p-cymene (0.4-8.9%), o-cymene (1.4-14.8%), sabinene (0.1-12.3%), β-pinene (0.7-14.2%), β-myrcene (1.2-11.0%), limonene (1.3-9.3%), sylvestrene (3.1-7.7%), and cymen-7-al (6.9-10.9%) were key volatile components identified in different parts of B. persicum using HS–GC/MS. These findings revealed a very high quantitative variation of VOs composition among the samples. The multivariate statistical analysis also classified these variations within the plants and their parts at two locations. HS-GC/MS technique can be utilized for the quality assessment and discrimination analysis of B. persicum, especially its essential oil (BEO). Further, essential oils of both the seed samples showed significant antioxidant activity in DPPH and ABTS assay. The current methodology will help to monitor the varietal development and smart agriculture practices as quality perspectives. [ABSTRACT FROM AUTHOR]

'One drug- one target' to 'multiple drug- multiple targets' paradigm shifted to produce combination therapies, have found great outcomes to overcome multiple drug resistance (MDR). MDR is a significant barrier to the delivery of taxane-based anticancer medicines such as docetaxel, paclitaxel, and cabazitaxel. Due to MDR induced by drug efflux transporters, clinical application of these medications is impeded. To date, nanoformulations such as liposomes, micelles, polymeric nanoparticles, and gold nanoparticles have been investigated to deliver taxanes alone and in combination to reverse drug resistance. Despite the fact that various groups have already looked into taxane nano formulations in the literature, there isn't much in the way of polypharmacology and advanced nanoformulations with a focus on MDR. In this overview, we briefly covered the insights regarding MDR, difficulties related to current pharmaceutical products of taxanes, combination therapies of taxanes to combat MDR, all of which can be used to delve into cancer treatment. [ABSTRACT FROM AUTHOR]

Endothelial dysfunction is related to the reduced bioavailability of nitric oxide (NO) and plays a significant role in developing hypertension. The intake of a diet rich in antioxidants decreases the threat of hypertension. Cissus quadrangularis possesses antioxidant, anti-inflammatory, and hypocholesterolemic activities. However, to date, no studies have been performed to explore this plant's antihypertensive and vasorelaxant activity. Herein, we investigated the chronic effect of C. quadrangularis on blood pressure as well as vascular function in hypertensive rats. Male spontaneously hypertensive rats (SHR) were randomly divided into two groups. Normotensive Wistar rats were taken as the control group. The treatment was done using ethanolic extract of C. quadrangularis (EECQ) at a dose of 200 mg/kg. The administration of EECQ for six weeks reduced the systolic blood pressure, mean arterial blood pressure, and heart rate. It also alleviated the cardiac and renal hypertrophy indices. Supplementation of EECQ improved the endothelium-dependent aortic vasodilation induced by acetylcholine. It restored the NO level and endothelial NO synthase expression in the aorta. Subsequently, the extract alleviates the oxidative stress and inflammatory markers in SHR rats. Thus, in the present study, the chronic treatment of EECQ to genetically hypertensive rats improved endothelium-dependent relaxation in addition to its antihypertensive effect by eNOS activation and inhibition of ROS production, inflammation. [ABSTRACT FROM AUTHOR]