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The Kennedy and O'Hagan (KOH) calibration framework uses coupled Gaussian processes (GPs) to meta-model an expensive simulator (first GP), tune its "knobs" (calibration inputs) to best match observations from a real physical/field experiment and correct for any modeling bias (second GP) when predicting under new field conditions (design inputs). There are well-established methods for placement of design inputs for data-efficient planning of a simulation campaign in isolation, that is, without field data: space-filling, or via criterion like minimum integrated mean-squared prediction error (IMSPE). Analogues within the coupled GP KOH framework are mostly absent from the literature. Here we derive a closed form IMSPE criterion for sequentially acquiring new simulator data for KOH. We illustrate how acquisitions space-fill in design space, but concentrate in calibration space. Closed form IMSPE precipitates a closed-form gradient for efficient numerical optimization. We demonstrate that our KOH-IMSPE strategy leads to a more efficient simulation campaign on benchmark problems, and conclude with a showcase on an application to equilibrium concentrations of rare earth elements for a liquid–liquid extraction reaction. [ABSTRACT FROM AUTHOR]

Longitudinal dispersal of migratory fish species can be interrupted by factors that fragment rivers, such as dams and reservoirs with incompatible habitats, and indirect alterations to variables, such as water temperature or turbidity. The endangered pallid sturgeon (Scaphirhynchus albus) population in the Upper Missouri River Basin in North Dakota and Montana is an example of such fragmentation and alteration due to the construction of dams. We applied a high-resolution, 2+-dimensional modelling framework composed of hydrodynamic and Lagrangian particle tracking components to simulate pallid sturgeon larval drift and dispersal along a 33-km section of the Upper Missouri River to evaluate three main issues: a comparison between multidimensional models and traditional 1-dimensional models, the sensitivity of hydrodynamics to channel morphology, and the implications of channel morphology on retention and transport-time metrics for larval fish. The results indicate that multidimensional models better represent breakthrough curves of transporting larvae compared to 1-dimensional models, especially for the long tail of slow drifters in the population. Results also indicate that channel morphology and hydraulic complexity play significant roles in larval dispersal with certain flow conditions and channel features increasing larval retention and providing potential management options to increase survival rates by adjusting flow conditions during spawning events. For example, modelling indicates increased retention times at discharges 23–38% daily flow exceedance, coincident with emergence of mid-channel sandbars. Findings additionally emphasize the need for improved understanding of biological factors that affect larval drift and dispersal. [ABSTRACT FROM AUTHOR]

In this study, we investigate the difference between shared electric bicycles (e-bikes) and conventional shared bikes operated by Citi Bike in New York City. We examine differences in usage by examining summary statistics and we develop conditional autoregressive models to examine differences in factors associated with trip generation. These factors include bike infrastructure, subway proximity, area demographics, land use, and elevation. We also control for border effects by identifying peripheral stations. The percentage of e-bike trips fluctuates across hours of the day, with a peak around 3 PM but diminishes during peak commuting hours. We find mostly no significant differences in factors associated with the generation of trips between the two modes. Exceptions include a larger effect on e-bike trip generation when the daytime worker population is larger; other differences are due to the racial composition around the station area, some land use categories, and elevation differentials. [ABSTRACT FROM AUTHOR]

Approximately 25% of accidents in the United States are caused by texting while driving, prompting the creation of several media campaigns to reduce such risky behavior. The current research examined whether death-related advertisements increase cell phone use while driving. Studies 1-3 found that individuals engaged in greater distracted driving in the presence of a mortality-themed texting advertisement. Study 2 demonstrated that participants were more likely to text on their cell phone using a driving simulator, leading to more swerving and collisions after viewing a death-related (vs. neutral) poster. Finally, using eye-tracking, Study 3 showed that participants who viewed a death advertisement looked away from the road and texted more as compared to persons in the control condition. Implications and future directions are discussed. [ABSTRACT FROM AUTHOR]

Although reducing conservatism would alleviate unnecessary constraints in processing, storage, transportation, and disposal of nuclear materials, excessively conservative approaches are still utilized in many safety analyses. Criticality safety limits are put in place to reduce the likelihood of having a nuclear criticality accident to a value that is deemed incredible but often utilize parameters that are conservative to the point of becoming incredible themselves. The analyses that determine criticality limits are supposed to be based on credible instead of incredible events and circumstance, highlighting the need to be able to distinguish between what is in the realm of possibility and what is not. This paper provides a quantitative approach for reducing unrealistically conservative parameters by recalculating limiting factors in a state that deviates from the worst-case scenario and assigning probability distributions to these systematic deviations. This provides a technical basis for replacing excessively conservative values with something that is both objective and reasonably bounding, which may be systematically utilized in any criticality safety analyses. The assumption of "perfect sphericity" in the TRUPACT-II package's fissile contents model was used as an example case to demonstrate the proposed approach for replacing qualitative reductions to conservatism with quantitative reductions. Through a series of Monte Carlo calculations and statistical analyses, it was shown that conservative deviations from sphericity will provide lower keff values, where the magnitude and impact of this deviation is system specific. The statistical significance from applying probabilistic conservatism will be dependent on the chosen κ value and integration limit for the exponential distribution, as it varies the degree of conservatism applied to any parameter of interest. This approach is not limited to geometric assumptions and may be applied to a variety of conservative parameters. In an effort to move toward a standard method for reducing conservatism, this objective approach may be used in lieu of or in conjunction with subjective methods for relaxing constraints. [ABSTRACT FROM AUTHOR]

Bayesian Optimization (BO) links Gaussian Process (GP) surrogates with sequential design toward optimizing expensive-to-evaluate black-box functions. Example design heuristics, or so-called acquisition functions, like expected improvement, balance exploration and exploitation to furnish global solutions under stringent evaluation budgets. However, they fall short when solving for robust optima, meaning a preference for solutions in a wider domain of attraction. Robust solutions are useful when inputs are imprecisely specified, or where a series of solutions is desired. A common mathematical programming technique in such settings involves an adversarial objective, biasing a local solver away from "sharp" troughs. Here we propose a surrogate modeling and active learning technique called robust expected improvement that ports adversarial methodology into the BO/GP framework. After describing the methods, we illustrate and draw comparisons to several competitors on benchmark synthetic exercises and real problems of varying complexity. [ABSTRACT FROM AUTHOR]

Some acoustic parameters of animal vocalisations have been shown to reliably indicate male quality and play a role in mate and rival assessment. Reindeer possess a peculiar vocal tract anatomy involving a laryngeal air sac which probably acts as an additional filter, making it a candidate species for novel investigations in the field of bioacoustics. We investigated whether some acoustic parameters of male rutting vocalisations were good indicators of age and body weight (used as an index for body size). We did this by performing acoustic analyses using recordings collected from a semi-domesticated reindeer population in northern Finland. We found the age of subadult males (aged 2.5–4.5 years) to be negatively correlated with formant F3 and formant spacing, suggesting that their vocalisations convey information on the caller's age. Individual formant frequencies were not affected by male body weight, but formant spacing was lower in heavier males. Despite the presence of the laryngeal air sac, formant spacing seems to be an acoustic parameter influencing mate and rival assessment in reindeer as it gives an honest indication of male body size. We discuss the importance of reliable acoustic cues to quality indices in sexual selection contexts. [ABSTRACT FROM AUTHOR]

Cavernicolous populations of the spider wasp Ageniella evansi Townes, 1957 (Hymenoptera: Pompilidae) nest deep within limestone caves at Colossal Cave Mountain Park near Tucson, Arizona, USA. These remarkable populations are the only truly cavernicolous pompilid wasps currently known. As many as 79 females were documented nesting simultaneously within Arkenstone Cave. The facts that the wasps do not nest near cave entrances but only deep within the interior of the caves, are philopatric to each occupied cave and have been present each year for decades confirm their cavernicolous behaviour as subtroglophiles. Studies conducted for over 30 years revealed many insights into the behaviour of these wasps in addition to their nesting deep within limestone caves, including: intraspecific and interspecific competition, plasticity in host selection, precision solar navigation, evidence that some form of communal nesting may be present and behaviour suggestive of rudimentary cognition in the species. This study demonstrates the importance of assessing all animals found in caves as potential ecological elements and not focusing solely on exotic troglobiotic species. [ABSTRACT FROM AUTHOR]

Capsule: Aquatic insects made up a relatively small part of the Grey Heron's diet, while Little Egrets consumed numerous beetles, both aquatic and terrestrial. Aims: To explore the extent of insect predation by Grey Herons and Little Egrets. Regurgitated pellets were collected from beneath trees in which herons and egrets were nesting. Methods: Seventy Grey Heron and 48 Little Egret pellets were collected from the RSPB reserve at Northward Hill, Kent. These pellets were disaggregated and prey items were collected and sorted under a binocular microscope. Results: Grey Herons fed on a relatively small number of aquatic beetles (Coleoptera: seven species, 32 individuals) and bugs (Hemiptera: two species, six individuals). Little Egrets, in contrast, fed on a diverse array of beetle species, both aquatic (three families, 11 species, 48 individuals) and terrestrial (10 families, 35 species, 111 individuals), and also a few aquatic bugs (one family, one species, three individuals). The extent of terrestrial beetles in the diet constitutes new information for Little Egrets. Conclusion: Insects, both terrestrial and aquatic, represent an important component of the diet of Little Egrets. For Grey Herons, insects are a very minor component of the diet, involving aquatic species only. [ABSTRACT FROM AUTHOR]

Recent research suggests that many environmental education (EE) programs for youth in the United States focus on meeting educational standards rather than using civic engagement and advocacy techniques to promote environmental literacy. We distributed a survey to members of several EE organizations to identify which civic engagement, advocacy, and behavior change techniques a sample of EE providers feel are appropriate to use for youth at different developmental stages (grades 4–5, grades 6–8, and grades 9–12), as well as the extent to which they use them. Educators rated many techniques as less appropriate and were less likely to use them with younger age groups. We also conducted an appropriateness/use analysis to identify techniques that were deemed highly appropriate but were not used as often. The techniques related to civic engagement and advocacy for diversity, equity, and inclusion appeared underutilized. Implications of these findings for policy and practice are discussed. [ABSTRACT FROM AUTHOR]

AbstractObjectivesDesignStudy SampleResultsConclusionsA case of sudden sensorineural hearing loss following use of sildenafil was examined in detail over a period of three days from first report to recovery.Case study. The subject presented with sudden sensorineural hearing loss and diplacusis a day after onset. Testing involved detailed interview, standard audiometry, detailed inter-octave audiometry, and measurement of detailed psychophysical frequency tuning curves during a two day recovery period.One male aged in his thirties with otherwise normal hearing.Although standard audiometry was within normal limits, detailed inter-octave audiometry and psychophysical frequency tuning curves were consistent with a punctate unilateral intra-cochlear lesion that resolved over a period of three days.This is the first report of such a frequency-specific audiometric shift and diplacusis after sildenafil, and is not consistent with previous reports of direct ototoxic pharmacological effects. We propose that the lesion was most likely caused by a cochlear bleed, and may have been due to physical exertion rather than a direct pharmaceutical effect. The study highlights the important role of additional diagnostic testing that can be easily achieved in a clinical setting with minimal equipment [ABSTRACT FROM AUTHOR]

Self-study researchers have periodically considered the essence of self-study, its objectives, its applications, and potential future trajectories. To address this imperative, our study undertakes a content analysis of the initial 19 volumes of Studying Teacher Education (STE), the flagship journal of self-study research. We focus specifically on the methodological dimensions of the scholarship featured in the journal, encompassing the spectrum of self-study methodologies employed, data collection techniques utilized, and measures of trustworthiness adopted. Through our analysis, we identify prevalent trends within each thematic domain, alongside an evolving consensus over time regarding the characteristics of high-quality self-study research. Nonetheless, we also discern persistent challenges concerning the lack of definitional precision and consistent implementation across diverse methodologies, data collection approaches, and trustworthiness measures. Echoing previous scholarship, we advocate for the establishment of a shared lexicon within the self-study community and the cultivation of explicit understandings regarding the diverse modalities of its application. Furthermore, drawing from our analysis, we introduce a typology delineating three distinct epochs of self-study research within the journal’s history while also envisioning the emergence of a fourth era poised to both reaffirm self-study’s foundational role as a form of counter-scholarship and chart innovative pathways forward. [ABSTRACT FROM AUTHOR]

Environmental education (EE) is instrumental in developing environmentally literate citizens with the knowledge, attitudes, and skills necessary to support sustainable development. In the case of EE school field trips in the USA, these experiences also foster learning and skill development that supports meeting state and national educational standards. However, despite the importance of EE field trip programs, not all schools participate. This study explored the barriers to accessibility to EE field trips by conducting semi-structured interviews with EE providers and administrators of middle schools in the Congaree Biosphere Reserve (CBR), South Carolina, USA. We also used geospatial information systems to investigate accessibility spatially. Results suggest that aspatial barriers such as curricular constraints, capacity to plan and lead field trips, costs, and transportation influence participation. The results also suggest that these aspatial barriers are often interlinked and that access to EE field trips is disproportionately allocated to students in private education and urban settings and that rural, poor, minority, underperforming, and English as Second Language students face additional hurdles. We discuss a range of potential solutions to overcoming these barriers that reduce participation in EE field trips in the CBR. [ABSTRACT FROM AUTHOR]

Political polarization in the United States has made many environmental issues strongly partisan, with Democrats largely receptive to environmental messaging and Republicans commonly pitted against it. This phenomenon may have meaningful implications for how environmental education is conducted for people from different sociopolitical contexts. We explored whether certain pedagogical approaches to single-day environmental education field trip programs were linked to better or worse outcomes for early adolescent youth (ages 10–14) from different sociopolitical contexts: majority Republican, majority Democrat, or mixed (roughly even). All observed effect sizes were small with one exception. Play-based pedagogies tended to yield less positive outcomes for students from Republican majority contexts than others, with a medium effect size. The findings suggest that some traditional approaches to play, such as role-playing as animals or pretending to be water droplets, may feel incongruent with the social identities of students from largely Republican communities. [ABSTRACT FROM AUTHOR]

In the United States, the two main political parties, Democrats and Republicans, have become increasingly polarized, including with regard to environmental issues. As part of a national study of environmentally focused single-day field trips for early adolescent youth in 2018, we conducted exploratory research to examine how outcomes differed for public school students from different sociopolitical contexts (i.e. predominantly Democratic, Republican, or mixed). Students from wealthier Democratic contexts exhibited less positive outcomes, measured as self-reported changes in environmental literacy, compared to others. The findings suggest that single-day EE field trips in the United States, in their current forms, may be particularly valuable in lower income and more politically conservative contexts, possibly due to the degree of novelty they may provide to these audiences. Meanwhile, EE field trips for students from wealthier Democratic contexts may provide reinforcement rather than meaningful shifts in environmental literacy, suggesting a need for more novel approaches for these audiences. [ABSTRACT FROM AUTHOR]

Tour guides play a central role in the implementation of sustainable tourism practices through maximizing tourists' appreciation and enjoyment of the destination and minimizing their negative impacts. Utilizing Stimulus–Organism–Response framework, this study aims to examine how tour guide performance directly and indirectly predicts tourists' pro-environmental behaviour. Confirmatory Factor Analysis and Structural Equation Modelling were used to test a pro-environmental behaviour model using a sample of 396 tourists who visited Serengeti, Lake Manyara, Tarangire national parks and Ngorongoro conservation area in northern Tanzania. The results indicated that tour guides positively and significantly influenced tourists' experience, satisfaction and pro-environmental behaviours. Further, tourists' experience is found to positively mediate the relation between tour guide and pro-environmental behaviour. The study presents managerial implications, limitations and future research directions in light of the results. [ABSTRACT FROM AUTHOR]

What is the availability and distribution of single-day environmental education field trip programs for adolescent students across the U.S.? We assessed the spatial accessibility to EE field trip programs for U.S. schools that serve grades 5-8 (ages 10-14) by (1) compiling a comprehensive national database of 2,930 EE providers that offer field trip programs, (2) identifying 89, 311 middle schools' locations, student populations, and relevant demographic information, and (3) calculating drive times between schools and EE provider locations using a high-performance computing cluster. We then used the integrated Floating Catchment Area method to calculate each school's relative spatial access to EE field trip providers. Results suggest that spatial access was highly spatially clustered, particularly around several geographic regions (coastal California metropolitan areas, the southern Rockies, northern Kentucky, North Carolina, the western shore of Lake Michigan, and the high-density, contiguous metropolitan areas of the Northeast). Spatial access was also strongly related to partisan lean and urbanity, with more rural, White, and Republican-leaning areas generally having significantly less spatial access to EE field trips. [ABSTRACT FROM AUTHOR]

Do preparation and perceived support from guardians and teachers influence student attendance to a residential environmental education (EE) field trip program? To explore this question, pre-visit surveys were administered to racially diverse sixth-grade students at seven schools invited to attend a residential EE program at no cost, namely NorthBay Education in North East, Maryland, USA. Results indicate that while desire to attend the residential camp did not differ by students' racial identity, Black and Latinx students were less likely to attend the program. Guardian support to attend and logistical preparation were each positively related to student attendance, irrespective of racial group, with Latinx students reporting the lowest levels of guardian support to attend. Black student attendance was also correlated with geographic and psychological preparation. Tailoring pre-trip preparation and engagement to address the unique needs of each schools' student body is likely needed to promote student attendance. However, these results indicate that inequities in program attendance persist across racial groups and further investigation into program conception, design, communication, and execution is needed to understand and address this concern. [ABSTRACT FROM AUTHOR]

Analysts’ observable careers are short. Around half of the analysts we study have observable lives of approximately three years. Using the IBES database as a proxy for the length of analysts’ careers, we find that distraction and herding shorten observable lives. There are important roles for economically rational influences. The length of observable careers is reduced by inaccuracy in forecasting. Issuing a first forecast early but, on average, delaying forecasts for the portfolio of firms they cover also increase analysts’ life spans. We find no robust association between life span and optimism or overconfidence. [ABSTRACT FROM AUTHOR]

Multi-site randomized controlled trials (RCTs) provide unbiased estimates of the average impact in the study sample. However, their ability to accurately predict the impact for individual sites outside the study sample, to inform local policy decisions, is largely unknown. To extend prior research on this question, we analyzed six multi-site RCTs and tested modern prediction methods—lasso regression and Bayesian Additive Regression Trees (BART)—using a wide range of moderator variables. The main study findings are that: (1) all of the methods yielded accurate impact predictions when the variation in impacts across sites was close to zero (as expected); (2) none of the methods yielded accurate impact predictions when the variation in impacts across sites was substantial; and (3) BART typically produced "less inaccurate" predictions than lasso regression or than the Sample Average Treatment Effect. These results raise concerns that when the impact of an intervention varies considerably across sites, statistical modeling using the data commonly collected by multi-site RCTs will be insufficient to explain the variation in impacts across sites and accurately predict impacts for individual sites. [ABSTRACT FROM AUTHOR]

Factors allowing rural, community-dwelling 80+ year-olds to thrive remain unexplored. Isolation can impact this vulnerable population. In this study, patients were prospectively surveyed for age, gender, cohabitation (self, spouse, family) and location (suburban, rural, and isolated). Mini-nutritional assessment short form (MNA-SF) and BMI were obtained. A p < 0.05 represented statistical significance. Patients (n = 167) were mostly female (120; 71.9%) with an average overweight BMI (26.5) and low-normal MNA-SF scores (11.8). Most live alone (49.7%), followed by spousal (31.7%) and family (18.6%) cohabitation. Over 80% are rural (71) or rural-isolated (67), and of these, 83% had normal nutrition. Self-habitation correlated with lower MNA-SF scores (p = 0.02). Normal BMIs correlated with family cohabitation (OR = 0.90 [CI: 0.82-0.99]) and nourished MNA-SF scores with spousal cohabitation (OR = 1.69; CI: 1.15-2.47) rather than living alone. Self-habitation increases vulnerability to obesity and malnutrition. Interventions should aim to maintain independence while improving the effects of habitation on nutrition. [ABSTRACT FROM AUTHOR]

Variants in the patatin-like phospholipase domain containing 6 (PNPLA6) gene cause a broad spectrum of neurological disorders characterized by gait disturbance, visual impairment, anterior hypopituitarism, and hair anomalies. This review examines the clinical, cellular, and biochemical features found across the five PNPLA6-related diseases, with a focus on future questions to be addressed. A literature review was performed on published clinical reports on patients with PNPLA6 variants. Additionally, in vitro and in vivo models used to study the encoded protein, Neuropathy Target Esterase (NTE), are summarized to lend mechanistic perspective to human diseases. Biallelic pathogenic PNPLA6 variants cause five systemic neurological disorders: spastic paraplegia type 39, Gordon-Holmes, Boucher-Neuhäuser, Laurence-Moon, and Oliver-McFarlane syndromes. PNPLA6 encodes NTE, an enzyme involved in maintaining phospholipid homeostasis and trafficking in the nervous system. Retinal disease presents with a unique chorioretinal dystrophy that is phenotypically similar to choroideremia and Leber congenital amaurosis. Animal and cellular models support a loss-of-function mechanism. Clinicians should be aware of choroideremia-like ocular presentation in patients who also experience growth defects, motor dysfunction, and/or hair anomalies. Although NTE biochemistry is well characterized, further research on the relationship between genotype and the presence or absence of retinopathy should be explored to improve diagnosis and prognosis. [ABSTRACT FROM AUTHOR]

According to contemporary diagnoses, democracy is foundering because of polarization. It is natural to think that if polarization is a problem, the remedy is to reconcile the conflicting sides. Yet reconciliation seems to involve the disturbing prescription that citizens should reconcile with radicals who have divested from democratic norms. That assumes, however, that polarization is symmetrical, whereby each side is equally responsible for it. But polarization need not depend on the assumption of such symmetry, such that depolarization may be possible without reconciliation. If so, polarization may be a problem not only between political alliances but within them. [ABSTRACT FROM AUTHOR]

Menstrual cycle has a significant impact on women's health from different perspectives, both physically and psychologically. The assessment of menstrual-related distress is of pivotal clinical interest, especially in women with chronic exposure to abnormal bleeding or pain. The Menstrual Distress Questionnaire (MEDI-Q) is a new tool originally developed in Italian that comprehensively evaluates menstrual-related distress. To validate the English version of the MEDI-Q in an English-speaking population. The study consisted of two phases: an initial translation phase of the original Italian version of the MEDI-Q, and a data collection phase to validate the new English version among 288 native English-speaking women. The English version of MEDI-Q showed excellent psychometric properties, with high internal consistency (Cronbach's alpha = 0.84) and test-retest reliability (intraclass correlation coefficient = 0.95). Construct validity was supported by significant correlations between MEDI-Q scores and scores on measures of psychological distress and premenstrual symptoms. The English version of the MEDI-Q is a valid and reliable instrument for the assessment of menstrual distress and its impact on psychological well-being. This tool can be utilized in research and clinical settings to comprehensively investigate the impact of menstruation on various populations, identify and monitor menstruation-related disorders promptly and effectively, and to evaluate the effectiveness of targeted treatments for menstrual distress. [ABSTRACT FROM AUTHOR]

The present research, utilising a terror management theory perspective, examined the effects of death awareness on Christians' explicit and implicit image of Jesus. Following exposure to mortality salience, participants were asked to complete a reverse correlation task (Study 1) or a forensic sketch task (Study 2) in an attempt to create an image of Christ. All composites were coded on multiple emotional dimensions (i.e., disgust, contempt, neutrality, happiness, fear, sadness, anger, & surprise). Across studies, the results revealed that participants primed with death created more overtly positive images of Jesus (i.e., less implicit anger, contempt, disgust; more happiness; greater explicit contempt). These findings suggest that a benevolent Christ serves as part of Christians' religious worldviews. A positive Jesus may thus function by protecting individuals against existential anxieties associated with the awareness of death. [ABSTRACT FROM AUTHOR]

Using survey data collected in New Jersey, we analyze the frequency of bicycling and respondent perceptions of the safety of various bicycling facilities. Data was collected via a mixed-mode survey design, including intercepts, bicycle hangers, flyers in bicycle shops, and a Facebook advertisement targeted toward bicyclists in New Jersey (N = 1937). This provided us with a reasonable sample of respondents that included bicycle commuters and non-cyclists. Data on cycling frequency was collected for recreational and commute trips. Respondents ranked the relative safety of images of bicycle facilities, ranging from cycling on-street to off-road trails. We also collected attitudinal data on risk perceptions and world views linked to political perspectives. Our analysis suggested that feeling safer with on-street bicycle lanes and off-street bicycle paths is not associated with the frequency of bicycling, while feeling safer on-street in traffic is associated with the frequency of bicycling. In analyzing correlates associated with our images of bicycling infrastructure, we found those with more liberal/egalitarian world views prefer on-street bicycle lanes and off-street bicycle paths, while those with traditional community world views tend to not feel safe with on-street bicycle lanes and bicycling in traffic. Those who are risk takers also feel safer bicycling in traffic. Most other demographic controls in our models give us the expected results. Policy implications suggest that bicycle infrastructure will be less controversial when world views are more liberal/egalitarian, but that making all streets safer might be a useful approach for increasing the frequency of bicycling. [ABSTRACT FROM AUTHOR]

The skull of Plioplatecarpus possesses large orbits and a large parietal foramen. Although the large orbits suggest that Plioplatecarpus possessed large eyes with enhanced visual performance, none of the previously described skulls include a sclerotic ring, and so it has been impossible in the past to reconstruct their size or optical properties. A recently collected skull with a sclerotic ring preserved in situ provides for the first time the data to do so. The dimensions of the sclerotic ring demonstrate that, although the f-number of the eyeball was not low enough to support the hypothesis that Plioplatecarpus was adapted to low light conditions, the eyeball was nevertheless large and possessed increased visual acuity and sensitivity that enabled the mosasaur to operate efficiently in both light-rich and light-poor conditions and possibly other conditions of reduced visibility. Proportions of this skull also suggest that Plioplatecarpus possessed a relatively wide binocular field of vision, providing stereoscopic vision, and further increasing both acuity and sensitivity, enhancing its ability to effectively detect and track quickly moving objects under a wide range of light conditions. A greatly enlarged parietal foramen implies the presence of a large parietal eye, the significance of which is uncertain, but it may have enhanced the ability to regulate migratory behavior. [ABSTRACT FROM AUTHOR]

Energy consumption across the African continent is expected to increase sharply in the next two decades, largely due to population growth, urbanization, and rising incomes. Much of the energy consumption is in the form of wood biomass, kerosene, and diesel. Africa's energy demand trajectory points to a future scenario where its contribution to global greenhouse gas emissions will threaten global sustainability. Furthermore, existing supply capacity is unlikely to meet the rising demand for energy. Africa's transition to renewable energy is needed to balance future energy supply and demand with climate-related externalities. A key barrier to this solution is Africa's energy finance gap, which calls for a concerted effort by investors in Africa's energy markets and governments, as well as global development partners. We highlight the direct link between Africa's energy finance gap and the long-run scenario for the global climate crisis. [ABSTRACT FROM AUTHOR]

Deep Gaussian processes (DGPs) upgrade ordinary GPs through functional composition, in which intermediate GP layers warp the original inputs, providing flexibility to model nonstationary dynamics. Two DGP regimes have emerged in recent literature. A "big data" regime, prevalent in machine learning, favors approximate, optimization-based inference for fast, high-fidelity prediction. A "small data" regime, preferred for computer surrogate modeling, deploys posterior integration for enhanced uncertainty quantification (UQ). We aim to bridge this gap by expanding the capabilities of Bayesian DGP posterior inference through the incorporation of the Vecchia approximation, allowing linear computational scaling without compromising accuracy or UQ. We are motivated by surrogate modeling of simulation campaigns with upwards of 100,000 runs—a size too large for previous fully-Bayesian implementations—and demonstrate prediction and UQ superior to that of "big data" competitors. All methods are implemented in the deepgp package on CRAN. for this article are available online. [ABSTRACT FROM AUTHOR]

Experimental studies of educational interventions are rarely based on representative samples of the target population. This simulation study tests two formal sampling strategies for selecting districts and schools from within strata when they may not agree to participate if selected: (1) balanced selection of the most typical district or school within each stratum; and (2) random selection. We compared the generalizability of the resulting impact estimates, both to each other and to a stylized approach to purposive selection (the typical approach for experimental studies in education). We found that balanced and random selection of schools within randomly selected districts were the most consistent strategies in terms of generalizability, with minimal difference between the two. Separately, for random selection, we tested two strategies for replacing districts that refused to participate—random and nearest neighbor replacement. Random replacement outperformed nearest neighbor replacement in many, but not all, scenarios. Overall, the findings suggest that formal sampling strategies for selecting districts and schools for experimental studies of educational interventions can substantially improve the generalizability of their impact findings. [ABSTRACT FROM AUTHOR]

To develop the criticality safety basis for any system, process, or package, the worst-case configuration of materials resulting in the maximum system reactivity must be determined. It is commonly accepted that in terms of the maximum system reactivity, at the lower enrichments used in current commercial practice (i.e., 5 wt% 235U), a heterogeneous configuration is bounding of a homogeneous mixture of fissile and moderating materials. However, a common assumption made is that with increasing enrichment, a homogeneous system can be bounding. With increased industry interest in utilizing higher enrichments for commercial applications with low-enriched uranium (LEU+) (≤10 wt% 235U), and high assay low-enriched uranium (HALEU) (≤20 wt% 235U) materials, it has become increasingly important to verify any assumptions and to have a better understanding of the expected system behavior at these higher enrichments. The SCALE code system was used to assess the effects of heterogeneity on system reactivity with varying enrichments and system configurations for a UO2 and water system, typical of a transportation package criticality analysis. The purpose of this assessment was to provide insight on the effect of material heterogeneity on system reactivity with increasing enrichment. The results of this study confirm that for systems with a higher hydrogen-to–fissile material (H/X) ratio, the homogeneous mixture of material may be bounding for HALEU materials. However, for systems with a lower hydrogen-to–fissile material ratio (H/X ≤ 200), a heterogeneous configuration of contents is expected to be bounding for most LEU materials. Overall, for any LEU system, including HALEU material, heterogeneous reactivity effects should always be considered. [ABSTRACT FROM AUTHOR]

Start-up STPs have a central initiative controlling the decision-making. In early maturity, better decision-making is required and decisions are best taken with the input of optimally two on-cluster firms; this ambidextrous situation is superior under all circumstances. Where poor-fit innovations abound and where the STP has been unable to attract large firms, retaining a hierarchical decision process is most helpful, even when the quality of decision-making is poor. This developmental trajectory will lead to market failure as size, and the seriousness of the concomitant potential losses, increases. With time, off-cluster firms move outward, inhabiting a band 4–7 km from the STP; their size remains modest and their innovation output is low. On-cluster firms are resilient to externalities; their innovation output is large and strongly correlated with social/networking expenditure. These new results are reviewed here as a contribution towards a "road map" to help STP decision-making and regional policy. [ABSTRACT FROM AUTHOR]

Variations in the protocadherin gene FAT1 have recently been associated with a syndrome that includes coloboma, facial dysmorphism, renal failure, syndactyly, and other developmental defects. Detailed medical and family history, physical examination, and molecular analysis. This non-dysmorphic, intellectually normal 51-year-old woman presented with bilateral colobomata and renal failure of unclear etiology, and asymmetric sensorineural hearing loss. Family history was notable for multiple family members with various forms of cancer. Whole exome sequencing revealed a homozygous frame shift variant in FAT1, predicted to truncate the FAT1 protein at the furthest position in the protein structure published to date in a patient with coloboma. This case provides further evidence of the pleiotropic effects of FAT1 in optic fissure closure and kidney function. Also, because this variant is in the last exon, it would be anticipated to escape nonsense-mediated decay, opening the possibility that the protein is made and expressed, but not completely functional, as its intracellular domain is truncated. [ABSTRACT FROM AUTHOR]

Chronic low back pain (cLBP) is a complex condition that is physically and psychologically debilitating, with vulnerable populations experiencing more severe outcomes. Physical therapy (PT) includes evidence-based treatments that can reduce disability, however the experience of PT can vary amongst different populations. Empirical evidence is largely based on majority samples that are predominantly white with high educational attainment. Little is known regarding how people from vulnerable groups (e.g. low income and racial minority) experience physical therapy treatment for low back pain. To describe the experience of physical therapy in a predominantly low-income and minority population with cLBP. This qualitative study was embedded within a randomized controlled trial for patients with cLBP in urban, underserved communities. We used a convenience sample to interview 12 participants from the 102 who participated in the PT arm of the trial and then performed thematic analysis to describe their experience. Three major themes emerged: 1) Empowerment through education and exercise; 2) Interconnectedness to providers and other patients; and 3) Improvements in pain, body mechanics, and mood. Divergent cases were few however centered around a lack of improvement in pain or an absence of connection with the therapist. Within the first theme a prevailing sub-theme emerged that aligned with Bandura's theory of self-efficacy: 1) Mastery of experience; 2) Verbal persuasion; 3) Vicarious experience; and 4) Physiological state. Our participants' insight highlighted the value of cognitive-emotional and interpersonal dimensions of PT. These may be particularly important components of PT in populations that have experienced systemic distrust in providers and disparities in services. Future work could use Bandura's model of self-efficacy to build a PT intervention comprised of fear-based movement exercises, interconnectedness, a strong therapeutic alliance, and mindfulness techniques. [ABSTRACT FROM AUTHOR]

Which approaches are associated with better student learning outcomes in environmental education (EE)? We observed a sample of 299 day-long EE field trip programs occurring across the U.S.A. for youth in grades 5–8 (ages 9 to 14). We tracked the extent of use and quality of implementation of 66 programmatic, educator, and setting characteristics and measured student outcomes immediately after the programs using a retrospective survey. A series of complementary tests identified 11 characteristics that were most powerfully and consistently associated with learning outcomes, accounting for 18% of variance in learning outcomes. These included group size, naturalness, novelty, place-based pedagogy, verbal engagement, quality questions, transitions, and staging, as well as the responsiveness, comfort and clarity, and emotional support provided by the educator. Some of the most commonly promoted practices in the EE field were rarely observed. Implications are discussed for both practice and research. [ABSTRACT FROM AUTHOR]

Do more natural settings improve students' learning? We collected surveys immediately following 283 U.S.-based environmental education (EE) field trip programs for youth and used land cover data to examine the relationship between levels of naturalness, defined as the percentage of natural land cover of the EE field trip site, and student learning outcomes. We also examined whether differences in levels of naturalness between students' day-to-day environment and the field trip setting were related to student learning outcomes. When controlling for grade and race, both levels of naturalness and novel levels of naturalness accounted for approximately 4% of the variance in student outcomes suggesting that other field trip characteristics are more influential. [ABSTRACT FROM AUTHOR]

Pediatric acute myeloid leukemia (AML) is a devastating disease with a high risk of relapse. Current risk classification designates patients as high or low risk (LR) based on molecular features and therapy response. However, 30% of LR patients still suffer relapse, indicating a need for improvement in risk stratification. Cytokine levels, such as IL-6 and IL-10, have been shown to be prognostic in adult AML but have not been well studied in children. Previously, we reported elevated IL-6 levels in pediatric AML bone marrow to be associated with inferior prognosis. Here, we expanded our investigation to assess cytokine levels in diagnostic peripheral blood plasma (PBP) of pediatric AML patients and determined correlation with outcome. Diagnostic PBP was obtained from 80 patients with LR AML enrolled on the Children's Oncology Group AAML1031 study and normal PBP from 11 controls. Cytokine levels were measured and correlation with clinical outcome was assessed. IL-6, TNFα, MIP-3a, and IL-1β were significantly higher in AML patients versus controls when corrected by the Bonferroni method. Furthermore, elevated TNFα and IL-10 were significantly associated with inferior outcomes. Our data demonstrate that in diagnostic PBP of LR pediatric AML patients, certain cytokine levels are elevated as compared to healthy controls and that elevated TNFα and IL-10 are associated with inferior outcomes, supporting the idea that an abnormal inflammatory state may predict poor outcomes. Studies are needed to determine the mechanisms by which these cytokines impact survival, and to further evaluate their use as prognostic biomarkers in pediatric AML. [ABSTRACT FROM AUTHOR]

The community conservation enterprises (CCEs) approach is used for advancing integrated conservation and development goals in Sub-Saharan Africa. CCEs aim to enhance resident livelihoods and reduce dependency on park resources. However, the impacts of CCEs are rarely demonstrable. This exploratory study of residents living adjacent to the Greater Virunga Landscape (GVL) in Rwanda and Uganda helps to address this gap by examining the household livelihood strategy of CCEs among GVL residents. Face-to-face interviews with 571 residents were conducted to assess satisfaction with their household livelihood security (food, education, health, financial). Results indicated that investment in CCEs has led to significant improvements in the livelihoods of residents in Rwanda. However, residents of Uganda reported marginal improvements. This study demonstrates the potential of CCEs for improving food and financial security in areas where tourism growth is substantial. Implications of these findings are discussed. [ABSTRACT FROM AUTHOR]

Deep Gaussian processes (DGPs) are increasingly popular as predictive models in machine learning for their nonstationary flexibility and ability to cope with abrupt regime changes in training data. Here, we explore DGPs as surrogates for computer simulation experiments whose response surfaces exhibit similar characteristics. In particular, we transport a DGP's automatic warping of the input space and full uncertainty quantification, via a novel elliptical slice sampling Bayesian posterior inferential scheme, through to active learning strategies that distribute runs nonuniformly in the input space—something an ordinary (stationary) GP could not do. Building up the design sequentially in this way allows smaller training sets, limiting both expensive evaluation of the simulator code and mitigating cubic costs of DGP inference. When training data sizes are kept small through careful acquisition, and with parsimonious layout of latent layers, the framework can be both effective and computationally tractable. Our methods are illustrated on simulation data and two real computer experiments of varying input dimensionality. We provide an open source implementation in the deepgp package on CRAN. [ABSTRACT FROM AUTHOR]

Many towns and cities have reallocated street space in response to the COVID-19 pandemic. This was done to allow more social distancing for physical activity and to provide space for restaurants to offer outdoor dining. We used data collected via an online Qualtrics panel of New Jersey residents (n = 1,419) to evaluate how these street closures were viewed. Did people take advantage of the opportunity to dine outside? Was walking more attractive with more space? How did respondents feel about changes in traffic patterns due to the closures? Did people walk more frequently? Results suggested that there was substantial public support for these types of interventions that allowed for more walking and more lively town centers (about 40%–45% of respondents expressed support, and only 35% had negative views; a large share was neutral). Those with negative views believed that street closures increased congestion and that outdoor dining made it more difficult to walk. In New Jersey, many towns are considering making COVID-inspired street changes permanent. There is broad support for this, though transportation agencies remain an impediment. We suggest that the current groundswell of support for street changes represents a rare opportunity to implement street design changes that support pedestrians and outdoor activities. [ABSTRACT FROM AUTHOR]

The operational sex ratio (OSR), the ratio of sexually active males to sexually receptive females, is one of the main measures used to predict the intensity and direction of mating competition, influencing the opportunity for sexual selection. Here, we conducted the first experimental study to investigate how OSR and male age impacts the intensity of mating competition in reindeer (Rangifer tarandus), under semi-natural conditions during the rut. We manipulated OSR on two levels in two enclosures, a female biased treatment (3♂:6♀ = OSR 0.5) and a sex balanced treatment (3♂:3♀ = OSR 1), over 2 years with males from two age groups, and with females of various ages. We found some support for prevailing OSR theory, notably with female intrasexual competition occurring at lower frequencies in OSR 1 than OSR 0.5, and male intrasexual competition occurring at higher frequencies in the older male age group. Courtship behaviour was found to occur at higher frequencies in OSR 1 than OSR 0.5; however, there was no effect of male age. To successfully pass on genes to the next generation, one needs access to mates and winning a competitive bout is not always indicative of successfully accomplishing gene flow. Studies on OSR have the potential to help us understand the drivers behind sexual competition and how best to predict breeding outcomes during a rut. [ABSTRACT FROM AUTHOR]

In reliability analysis, methods used to estimate failure probability are often limited by the costs associated with model evaluations. Many of these methods, such as multifidelity importance sampling (MFIS), rely upon a computationally efficient surrogate model like a Gaussian process (GP) to quickly generate predictions. The quality of the GP fit, particularly in the vicinity of the failure region(s), is instrumental in supplying accurately predicted failures for such strategies. We introduce an entropy-based GP adaptive design that, when paired with MFIS, provides more accurate failure probability estimates and with higher confidence. We show that our greedy data acquisition strategy better identifies multiple failure regions compared to existing contour-finding schemes. We then extend the method to batch selection, without sacrificing accuracy. Illustrative examples are provided on benchmark data as well as an application to an impact damage simulator for National Aeronautics and Space Administration (NASA) spacesuits. [ABSTRACT FROM AUTHOR]

Global neonatal mortality necessitates access to immediate newborn care interventions. In Nepal, disparities persist in the readiness and availability of newborn care services within health facilities. This study aimed to assess this status and compare facilities that had implemented an intensive newborn resuscitation capacity building and retention programme in the past five years with those that had not. Our observational cross-sectional study involved 154 health facilities across Nepal. Through on-site inspections and maternal log reviews, we evaluated the immediate newborn care readiness and availability. The mean immediate newborn care intervention availability score of 52.8% (SE = 21.5) and the readiness score averaged 79.6% (SE = 12.3). Encouragingly, 96% of facilities ensured newborns were dried and wrapped for warmth, and 69.9% provided newborn resuscitation. Practices such as delayed cord clamping (42.0%), skin-to-skin contact (28.6%), and early breastfeeding (63.5%) showed room for improvement. Only 16.1% of health facilities administered Vitamin K1 prophylaxis.Domain-specific scores demonstrated a high level of facility readiness in infrastructure (97.5%), medicine, equipment, and supplies (90.6%), and staff training (90.9%), but a lower score for neonatal resuscitation aids (28.8%). Disparities in readiness and availability were evident, with rural areas and the Madhesh province reporting lower scores. Variations among health facility types revealed provincial and private hospitals outperforming local-level facilities. A positive association was observed between the LDSC/SSN mentoring programme and both the readiness and availability of immediate newborn care services. This study highlights the gap between healthcare facility readiness and the actual availability of immediate newborn care interventions in Nepal. Addressing disparities and barriers, particularly in rural areas and local-level facilities, is crucial for improving neonatal survival. The positive link between the LDSC/SSN programme and service availability and facility readiness emphasises the significance of targeted training and mentorship programmes in enhancing newborn care across Nepal. [ABSTRACT FROM AUTHOR]

We show that a complex symmetric matrix of the form A (Y , B) = [ Y B B ⊤ Y ¯ ] , where B is Hermitian positive semidefinite, has a nonnegative hafnian. Some positive scalar multiples of matrices A(Y, B) are encodable in a Gaussian boson sampler. Further, the hafnian of this matrix is non-decreasing in B in the sense that haf A(Y, L) ≥ haf A(Y, B) if L ⪰ B. [ABSTRACT FROM AUTHOR]

This paper examines the current state of knowledge focusing on the second-order impacts of the COVID-19 pandemic through a geospatial lens. The purpose is twofold: (1) present a global programme – Cities' COVID Mitigation Mapping (C2M2) programme – focusing on urban areas that explores second-order impacts through the use of geospatial tools and technologies, and (2) identify and assess the emerging literature on second-order impacts using geospatial data and analysis to support this project. Effects of the pandemic are rapidly unfolding across the world; however, an assessment of the literature reveals that second-order impacts of COVID-19 are seasonal, spatial, and scalar across multiple thematic areas includ-ing the economy, environmental health sector, education, and migration/mobility. Successive waves of the pandemic are continuing to be met with specific public health measures (e.g. lockdowns, travel restrictions, social distancing guidance, mandates for the use of personal protective equipment) that will have long-term impacts on vulnerable populations. A literature review was conducted to identify how the pandemic's second-order impacts derived from geospatial data and analysis can provide the basis for using geospatial data to study vulnerable urban populations more generally. This review reveals a gap in the literature, with far more articles emphasizing geospatial approaches to assess first-order impacts and alimited number of articles focused on geospatial approaches investigating second-order impacts. Nonetheless, this nascent literature provides the basis for designing approaches with local partners and by local and regional governments to apply geospatial data and methodologies to the development of mitigation strategies to prioritize limited resources to minimize the long-term consequences of COVID-19. [ABSTRACT FROM AUTHOR]

This work proposes a theoretical approach to assessing agility in terms of a modified version of resilience during large-scale crisis to sustain operational reliability. The proposed method could be used on subsystem optimization or eventually scaled up to global interconnectedness enabling decision makers to optimize resource allocation and so obtain resilience and agility in troubling times along with long-term sustained prosperity. Introducing weights to various parameters can also allow customizing outcomes such as insuring equitable outcomes, environmental stewardship and proper response to emergencies or any national crisis. The provided mathematical formalism can then become a decision maker tool to predict corrective action outcomes from various responses to a crisis or alternatively to determine sensitivity and potential risk for a crisis from apparently ambient or slowly changing conditions. Ad-hoc examples are considered to demonstrate the generality of the approach. [ABSTRACT FROM AUTHOR]

While physical therapy may help improve function and quality of life in patients with neurofibromatosis (NF), a standard of care remains to be established. This case report describes the physical therapy management of an individual with NF who was at high fall risk. A 61-year-old male with NF and multiple comorbidities was determined to be at high fall risk by the Dynamic Gait Index, Berg Balance Scale, and Modified Falls Efficacy Scale. Deficits included coordination and strength which limited his ability to ascend and descend stairs or walk on uneven terrain. This reduced his independence at home and in his rural community. Interventions incorporated components of hip and trunk coordination, and addressed balance, strength, and functional mobility. The patient scored above the cutoff for high fall risk on all outcome assessments. This case report describes physical therapy management to reduce fall risk for an individual with NF. Due to the limited research on NF, the treatment plan was developed using evidence-based practice for fall-risk reduction in other neurological disorders. [ABSTRACT FROM AUTHOR]