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Brazil is one of the world's leading fruit producers and its processing must be exploited as a means of value aggregation. The new food habits of the population show a concern with health and the search for healthier foods, but the current population model of life requires that these products do not lose their convenience and practicality. The purpose of this work was to produce spray-dried mixed pulp of passion fruit and mango and to assess physical, chemical, microbiological and morphological stability during the shelf life. The bioactive compounds of microspheres were analyzed as to the content of carotenoids, phenolic compounds, vitamin C and antioxidant activity. Microspheres were also evaluated for the stability of color, water activity, solubility, and microbiology. The microstructure and morphology of the microspheres were obtained from the analysis of the distribution of particle size, x-ray diffraction, and electron microscopy scanning. No significant losses were observed (p < .05), for bioactive compounds. The carotenoids, phenolic compounds, Vitamin C and antioxidant activity remained stable throughout the 90 days of storage of the microspheres. The powder presented stable coloring, highly soluble, microbiologically safe for consumption and low water activity. The microstructure and morphology presented the typical nature of microencapsulated products obtained by spray drying. The microencapsulation was effective in protecting the bioactive compounds by keeping them stable throughout the study period. The powder obtained can be used as a functional ingredient in food products thereby enriching them with bioactive compounds. [ABSTRACT FROM AUTHOR]