Search

High levels of miR-19 play an important role in malignant diseases of the hematopoietic system. Therefore the treatment with corresponding microRNA antagonists seems to be an interesting therapeutic approach. We found a significant increase of apoptosis in Jurkat cells which were transfected with a miR-19b inhibitor. The rise of apoptosis in transfected human monocuclear cells (MNCs) was significant as well, but the unspecific miRNA control induced apoptosis in MNCs to a similar extend. A closer look at the MNC subpopulations revealed higher specific apoptosis in B cells whereas T cell apoptosis was lower and induced by unspecific miRNA interference. [ABSTRACT FROM AUTHOR]

The current study compared eye fixation patterns during word and sentence processing in a consistent and an inconsistent alphabetic orthography. German and English children as well as adults matched on word reading ability read matched sentences while their eye fixation behavior was recorded. Results indicated that German children read in a more small-unit plodder-like style with more diligent first-pass reading and less rereading. In contrast, English children read in a more large-unit explorer-like style with a greater tendency to skip words, and more regressions. It is important that these cross-linguistic processing differences largely persisted in the adult readers. Orthographic consistency thus influences both local word recognition and global sentence processing in developing and skilled readers. [ABSTRACT FROM PUBLISHER]

We studied the transition in predominant reading strategy from serial sublexical processing to more parallel lexical processing as a function of word familiarity in German children of Grades 2, 3, 4, and adults. High-frequency words, low-frequency words, and nonwords of differing length were embedded in sentences and presented in an eye-tracking paradigm. The size of the word length effect was used as an indicator of serial sublexical decoding. When controlling for the generally higher processing times in younger readers, the effect of length over reading development was not direct but modulated by familiarity: Length effects were comparable between items of differing familiarity for Grade 2, whereas from Grade 3, length effects increased with decreasing familiarity. These findings suggest that Grade 2 children apply serial sublexical decoding as a default reading strategy to most items, whereas reading by direct lexical access is increasingly dominant in more experienced readers. [ABSTRACT FROM PUBLISHER]