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AbstractBackgroundMethodsResultsConclusionThe medical profession has traditionally had a culture of “blame and shame,” despite the importance errors have for learning, motivation, and improvement of clinical skills. This study aimed to explore how medical students and newly graduated doctors perceive errors across different learning contexts and levels of expertise, and how error perceptions influence motivation and engagement in learning activities.Semi-structured interviews were conducted, and thematic analysis was used to identify themes. Survey questions were developed based on the themes. The final survey included 27 questions divided into three sections. The survey was distributed via RedCap to medical students in year 1, year 4, and year 6 together with newly graduated doctors in Denmark.Of the 541 respondents, a majority anticipated making errors in both non-clinical (77.4%) and clinical (61.5%) learning situations, finding them motivating for participation (91.9% and 96.2%, respectively). A psychologically safe learning environment was seen to enhance the perception of errors as learning opportunities (96.9%) and increase risk willingness (96.3% non-clinical, 97.7% clinical). Respondents focused on the specific errors they made (86.0%), and their supervisors were perceived to focus more on correct handling of errors (70.7%). Respondents expected to conduct fewer errors in non-clinical learning situations in PGY-1 compared to medical students in year 1 (F(3529) = 3.0, adjusted p = 0.03). They showed an increase in risk willingness in clinical learning situations from year 6 to PGY-1 (F(3520) = 2.7, adjusted p-value 0.006) as long as the learning situations were considered psychologically safe.The study suggests that a psychologically safe learning environment mitigates the “shame and blame culture” associated with errors. Respondents generally embraced errors as valuable learning experiences but noted a lack of specific error-related feedback. These findings underscore the nuanced relationship between errors, explicit learning activities, and supervisor support in medical education. [ABSTRACT FROM AUTHOR]

Each year, Spotify nudges users to share aesthetically pleasing data stories ‘wrapped’ and repackaged from their listening behavior. This article approaches Spotify Wrapped as an annual algorithmic event, defined as a moment in time in which there is a collective orientation towards a particular algorithmic system and its associated data. It offers a methodological contribution to research on datafication of music taste and identities through the development of a workshop format aimed at ordinary Spotify users. The workshop delivers insights into practices of datafication and the normative assumptions baked into Spotify data stories. Drawing on a data feminist framework, we outline three interconnected but distinct creative exercises, which take participants on an analytical journey. We combine feminist arts-based research methodologies with critical reflection and the walkthrough method to centre people’s experiences and equip them to analyze different layers of Wrapped. Our theoretical and methodological approach seeks to destabilize the logics of data extraction that further Spotify’s commercial aims and its associated claims of ‘knowing us’ through the aggregation of user data. As such, our workshop transforms the marketing campaign into a site for critical reflection on Wrapped as an algorithmic event. [ABSTRACT FROM AUTHOR]

AbstractIntroductionAimMethodsResultsConclusionColorectal cancer (CRC) is among the most common cancers and the prognosis of CRC is highly dependent on stage at diagnosis. Although many cases are diagnosed swiftly, there is still room for improvement.We aimed to explore CRC diagnostic pathways, encompassing (1) place of initial contact; (2) associations with symptom presentations, sex, and age with events in the diagnostic process and initial referrals and (3) the general practitioner’s (GP’s) evaluation of the diagnostic processes.All GPs in North-, Central-, and Southern Denmark were invited to fill in questionnaires for their listed patients diagnosed with cancer during the past two years.Among 1,032 recorded CRC patients, 65% had their initial contact in general practice, 5% within the out-of hours service, 10% in the hospital, and 20% were diagnosed based on screening. A total of 27% of CRC patients over 40 who initially presented in general practice were treated or referred on suspicion of another disease first, and 9% were reported to have had hesitated in seeking medical attention. Some 37% presented solely non-specific symptoms, increasing the odds of the GP advising watchful waiting (OR 2.48; 95% CI 1.06–5.81), treating or referring on the suspicion of another illness first (OR 2.57; 95% CI 1.76–3.75), wait due to normal findings (OR 2.11; 95% CI 1.16–3.85), or referring to diagnostic imaging (OR 3.07; 95% CI 1.63–5.79). The GPs assessed nearly one fifth of the diagnostic processes as poor.Most CRC patients are diagnosed with initial presentation in general practice. Having non-specific symptoms is common and challenges timely diagnosis. [ABSTRACT FROM AUTHOR]

ObjectiveMethodResultsConclusionThe north–south gradient hypothesis proposes that individuals with rheumatoid arthritis (RA) residing in southern regions manifest a younger age of onset and milder disease compared to their northern counterparts. This study aimed to compare treatment-naïve, new-onset RA patients in Denmark and Turkey, examining demographic, clinical, laboratory, and genetic parameters.Prospective data collection was conducted, with all patients meeting the 2010 American College of Rheumatology/European League Against Rheumatism criteria. Shared epitope (SE) allele carrier frequencies were examined for genetic comparisons between patients and normal controls.Out of 223 RA patients, 109 were Danish and 114 Turkish. Danish patients exhibited a median age at onset of 60 years, whereas Turkish patients were younger at 51 years (p = 0.0007). The Danish cohort displayed significantly more swollen and tender joints, resulting in higher Disease Activity Score based on 28-joint count–C-reactive protein (DAS28-CRP). Danish RA patients and controls possessed more RA risk-enhancing alleles (S2 + S3P) and fewer risk-protective (S1 + S3D) alleles than Turkish patients and controls.This study substantiates the north–south gradient hypothesis, highlighting that new-onset RA patients in Denmark tend to experience an older age of onset and more severe disease activity than their Turkish counterparts. Variations in risk-enhancing alleles and fewer risk-protective alleles in Danish patients and controls are associated with these distinctions. Future research should investigate the genetic and environmental factors underlying these regional disparities, exploring their persistence in the long-term course of the disease through follow-up studies. [ABSTRACT FROM AUTHOR]

Based on fieldwork in Danish families living with ADHD, we expand on Nielsen's insight that ADHD is experienced as a state of desynchronization by showing how family members' rhythms mutually affect each other. We argue that ADHD is not only a biological and psychiatric condition, but also a temporal and socially responsive phenomenon. The intensity of ADHD is influenced by mutual affect in families and by general life circumstances. Families constitute bodily networks through which sensations, moods, rhythms, and practices spread and are passed down through generations. Yet, families use various time work strategies to manage rhythm affect. [ABSTRACT FROM AUTHOR]

The ability to mobilise public opinion is central to interest group politics. Yet, whether and how groups succeed in swaying the public remains inconclusive. The article assesses this by conducting a field experiment in which a consumer group sent different versions of campaign material to a representative sample of over 5000 citizens. Relying on a two-wave panel survey, it shows that while the campaign affected intended consumer behaviour, it did not influence attitudes. Surprisingly, material by the organisation alone was more effective than material sent with a partner. Moreover, campaign references to personal experiences and facts were not more effective than material referring to public opinion. The findings challenge existing evidence on how sender and message characteristics affect the likelihood of influencing citizens. At the same time, they underline that public opinion is hard to change and have important implications for understanding political representation and interest groups in democratic politics. [ABSTRACT FROM AUTHOR]

Ibogaine is a natural psychoactive drug that has been investigated for its potential role in the treatment of substance use disorders since the mid-1960s. To evaluate the interest in ibogaine's use as a therapeutic agent, we performed a scientometric analysis covering the last three decades (1993–2002, 2003–2012, and 2013–2022). A complementary analysis was performed to select and describe published clinical trials and meta-analyses. A total of 1523 references were found. Linear growth of publications in the first and third decades were identified, and the average number of publications from 1993 to 2002 was lower than that in the other two decades. Researchers from five continents were identified. Globally, academic research centers in the United States and Canada were the most productive. Cocaine, tobacco, morphine, and alcohol prevailed as major keywords in the first two decades and opioids and psychedelics were included in the third decade. A few key authors were the most co-referenced. One preclinical meta-analysis and no meta-analysis in humans were found. Research trends for ibogaine are widespread, growing, and consonant with current attentiveness in drug abuse. Our findings support the pressing need for rigorous clinical research on ibogaine to evaluate its efficacy and safety. [ABSTRACT FROM AUTHOR]

Background: Fecal Microbiota Transplant (FMT) is an effective treatment for recurring Clostridioides Difficile Infections (rCDI). FMT administered via oral capsules (caFMT) offers several practical advantages to conventional liquid FMT. We began using caFMT in 2021 imported from an external institution. Based on similar production methods, we began our own caFMT production in 2022. We aimed to evaluate the quality of our caFMT. Study Design and Methods: We created a database of all FMT treatments (n = 180) provided by our institution. Quality of all FMT was evaluated by treatment success rates. We compared our caFMT to the imported caFMT. Results: Our caFMT yielded similar success rates compared to that of the imported caFMT, 65% (CI 95% 58–72%) and 72% (CI 95% 66–79%) respectively. FMT administered via colonoscopy had a significantly higher success rate, 79% (CI 95% 73–85%) than own our caFMT and other routes of administration. The combined success rate of treatments increased notably for all routes of administration when repeating FMT after prior failure. Discussion: The fact that our caFMT compared similarly to the imported caFMT was viewed as a success in terms of quality assurance. Our caFMT had a slightly lower success rates compared to data from other studies, but could be affected by several other factors than our FMT-production methods. A lower success rate of caFMT compared to FMT via colonoscopy is acceptable due to the practical advantages offed by caFMT. Our study serves as a practical example, proving that of the standardization of caFMT production is indeed viable. [ABSTRACT FROM AUTHOR]

As food transits the gastrointestinal tract, food structures are disrupted and nutrients are absorbed across the gut barrier. In the past decade, great efforts have focused on the creation of a consensus gastrointestinal digestion protocol (i.e., INFOGEST method) to mimic digestion in the upper gut. However, to better determine the fate of food components, it is also critical to mimic food absorption in vitro. This is usually performed by treating polarized epithelial cells (i.e., differentiated Caco-2 monolayers) with food digesta. This food digesta contains digestive enzymes and bile salts, and if following the INFOGEST protocol, at concentrations that although physiologically relevant are harmful to cells. The lack of a harmonized protocol on how to prepare the food digesta samples for downstream Caco-2 studies creates challenges in comparing inter laboratory results. This article aims to critically review the current detoxification practices, highlight potential routes and their limitations, and recommend common approaches to ensure food digesta is biocompatible with Caco-2 monolayers. Our ultimate aim is to agree a harmonized consensus protocol or framework for in vitro studies focused on the absorption of food components across the intestinal barrier. [ABSTRACT FROM AUTHOR]

A 68-year-old male presented with a one-month history of progressive proptosis and vision loss in the left eye. Examination of the left eye showed visual acuity of NLP, marked relative proptosis of 10 mm, and complete external ophthalmoplegia. CT orbits showed an extensive left orbital lesion with proptosis. Urgent orbital biopsy was undertaken. Intraoperatively, the patient developed new atrial flutter and fever. Bloodwork revealed metabolic derangements suggestive of tumor lysis syndrome. Systemic evaluation revealed a large tumor burden involving the retroperitoneal space. Histopathology of the orbital specimen showed non-germinal center diffuse large B-cell lymphoma. The patient passed away 3 days postoperatively due to rapidly progressive multisystem organ failure. Our case demonstrates an unusually aggressive presentation of DLBCL in which orbital mass was the first presentation of spontaneous tumor lysis syndrome owing to large systemic tumor burden. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has reshaped life for all in countless ways. For young people, the pandemic accelerated the digitalization of school education and upended relations with peers, parents, and society as a whole. In this paper, we look beyond these immediate effects to explore how pandemic experiences, feelings, and thoughts suggest profound shifts in young people's perspectives on and orientations towards the future. Our research comprises parallel qualitative research with young people aged 15–19 in Denmark and Australia. Drawing on a posthumanist account of the world as entanglements of multiple human and non-human agencies and inspired by Donna Haraway's admonition to stay with the trouble of the world, we discuss how species meet as the coronavirus makes kin with the young people and how the young people's perspectives on the future become with the pandemic. That is, what intimations of worldings and reworldings can be glimpsed as young people shared their changed perspectives on priorities related to the meaning of life and the sustainability of the (more-than-) human condition from the midst of the pandemic. [ABSTRACT FROM AUTHOR]

Family engagement in childcare is important to ensure the optimal growth, development, and safety of children. Previous research has explored family engagement practices, but limited research is available on the application of theory to explain the uptake of family engagement principles. The purpose of this study was to explore the use and perceptions of the National Association of the Education for Young Children's six principles of effective family engagement among childcare providers from various childcare settings following the Innovation-Decision Process of the Diffusion of Innovation Theory. A semi-structured interview with a card-sorting task was used to explore providers' knowledge, adoption, and perceived difficulty of implementation as well as their perceived outcomes, reasoning for use or non-use, and advice on use of the family engagement principles. Notable findings suggest variance in childcare providers' knowledge, adoption, and perceived difficulty of all six family engagement principles. Childcare providers mentioned various perceived outcomes and reasoning for use of principles, such as improved relationship with parents and enhanced child learning. Lack of time and perceived disinterest of parents were commonly reported difficulties for the use of family engagement principles. Future studies should expand upon the exploration of family engagement practices and comparison between different childcare settings and philosophies. Further efforts are needed to investigate effective integration and use of technology for communication. [ABSTRACT FROM AUTHOR]

With the increasing focus on issues of race/ethnicity and sex/gender1 across the spectrum of human activity, it is past time to consider how instruction in research integrity should incorporate these topics. Until very recently, issues of race/ethnicity and sex/gender have not typically appeared on any conventional lists of research integrity or responsible conduct of research (RCR) topics in the United States or, likely, other countries as well.2 However, I argue that not only can we incorporate these issues, we should do so to help accomplish some of the central goals of instruction in research integrity. I also offer some initial suggestions about where and how to incorporate them within familiar topics of instruction. [ABSTRACT FROM AUTHOR]

Artificial intelligence (AI) natural language processing (NLP) systems have the potential to be widely used in scientific and scholarly publications. These systems convert unstructured text into structured text suitable for computation, allowing computers to interact with human language. While NLP systems can generate coherent and informative text, there are concerns about accuracy, bias, relevance, and reasoning. They may produce erroneous or misleading information and reflect biases in the data they are trained on. Therefore, any text generated by an NLP system should be checked by a domain expert for accuracy, bias, relevance, and reasoning. Researchers should also prioritize accountability, transparency, and data integrity when using NLP systems in research. The article calls for the adoption of policies on the use of AI in research and highlights ongoing ethical considerations in this field. [Extracted from the article]

Impulsivity tends to play an important role in many behavioral disorders, especially in the population of incarcerated offenders, where the prevalence of impulsivity is expected to be high. Prisoners sentenced for violent or property crimes, recruited from 12 participating prisons in the Czech Republic, completed self-reported questionnaires of impulsivity. Results were compared to a non-prison control group from the general population. Analyses pointed toward significantly higher levels of impulsivity in the prison population sample, particularly in terms of motor and non-planning impulsivity, emotion based rash action and sensation seeking, and impulsivity toward physical pleasures, social interactions and money. Findings were adjusted to demographic confounders. The relevance and importance of these findings within the forensic context is discussed. [ABSTRACT FROM AUTHOR]

AbstractObjectiveMethodResultsConclusions\nHIGHLIGHTSContemporary approaches to suicide assessment and treatment incorporate reasons for living (RFL) and reasons for dying (RFD). This study qualitatively explored individuals’ self-described RFL and RFD in the context of suicidal thinking and behaviors.Within a community United Kingdom (UK) sample, adults (N = 331, aged 16+) responded to eight open-ended questions probing their experiences of suicide, defeat, and entrapment. Utilizing these data, which were collected from a larger online survey examining risk and protective factors for suicidal behaviors, this study explored RFL and RFD within these narratives. After the research team established an initial code book, RFL and RFD codes were subsequently analyzed through inductive and deductive thematic analyses.The present study identified five complimentary RFD-RFL themes: (1) Hopelessness-Hopefulness, (2) Stress of Responsibilities-Duty to Responsibilities, (3) Social Disconnection-Social Connection, (4) Death as Sin-Desire for an Afterlife, and (5) Temporary Escapes as Coping-Entrapment (i.e., a lack of escape). Three subthemes within the RFD theme Entrapment were General/Unspecified, By Feelings, and Within Self.Identified themes reflect the existing quantitative RFL and RFD literature. The identified RFL and RFD themes are discussed with reference to their clinical applications in advancing suicide-specific assessments and interventions. We propose a dimensional framework for RFD and RFL which informs future suicidal behaviors research and practice.The study highlights the complex co-existence of reasons for dying and reasons for living.Reasons for living and dying should be explored in parallel in a therapeutic setting.The relative value placed on RFL/RFD by the individual should also be considered. [ABSTRACT FROM AUTHOR]

Andropause, the notion that men's aging is affected by a declining testosterone production, has until recently been a somewhat unknown phenomenon in the Danish context. However, as a growing number of Danish websites are disseminating information about 'the male climacteric', a new hormone centered health discourse about the male body is emerging. In this article, we analyze a corpus of 50 Danish websites consisting of both online media articles and websites marketing products for 'andropausal' men. We show how men's health and performances of masculinity in mid- and later life is entangled in biomedical discourses of risk and self-surveillance, as well as (biopolitical) affects centering aging men's sexual capacities. We base our analysis in new materialist thinking which outlines affect, biopolitics and complexity as entry points to embodied dimensions of masculinity. We argue that the growing attention to andropause promote new norms for aging in which the aging body is designated as unhealthy and the individual is required to remain vital and capable throughout life. Finally, drawing on Steve Garlick, we show how online available testosterone home-testing kits can be read as illustrative of the theory of masculinity as a technology of embodiment which rests upon the control over nature. [ABSTRACT FROM AUTHOR]

Traditional conceptions of personality disorder (PD) view severe identity disturbance as a defining characteristic of borderline personality disorder (BPD). In the alternative DSM-5 model for PDs (AMPD) and in the outlined substantial changes to PD diagnostics in ICD-11, disturbances in self and identity are elevated from a specific diagnostic criterion for BPD to a defining criterion for PD in general. In line with Kernberg's theory of personality organization (PO), it is expected that although identity disturbance may be characteristic of most or all PDs, severe identity diffusion is a more pronounced and defining characteristic of BPD and possibly other PDs organized on a borderline level (BPO). Here, we examined the level of identity disturbance in SCID-diagnosed patients with BPD, narcissistic PD (NPD), avoidant PD (AVPD), comorbid BPD with NPD and AVDP, as well as other specified PD (PD-OT). We found that measures of identity diffusion were higher in BPD and NPD patients compared with patients diagnosed with AVPD. Hierarchical multiple regression analyses showed that number of SCID criteria met for BPD and NPD predicted level of identity diffusion when gender, age and general symptomatology were controlled for, whereas number of SCID criteria met for AVPD did not. The presented data support severe identity diffusion as a prominent characteristic of BPD with possible implications for how we should differentiate BPD from other PDs. The findings are discussed in relation to Kernberg's model and the AMPD. [ABSTRACT FROM AUTHOR]

Introduction: Noncommunicable diseases (NCDs) constitute a massive global burden and are the leading cause of death and disability worldwide. In Greenland, the prevalence of NCDs has historically been low. However, during the past approximately 70 years, life circumstances have changed dramatically resulting in increased life expectancy. Today, the proportion of inhabitants in Greenland ≥65 years has nearly tripled since the 1980s, and the prevalence of obesity and diabetes has increased rapidly within the past decades. The aim of this study was to describe the burden of selected NCDs in a primary care setting in Nuuk and compare it to a modern westernized suburban general practice in Denmark. Methods: The study was performed as a cross sectional register-based study using data extracted from the electronic medical records (EMR) based on diagnosis codes from inhabitants living in Nuuk, Greenland, and a suburb in Denmark. Estimates of prevalence were age-standardized to the WHO world standard population. Results: In both Nuuk and the Danish suburb, the highest prevalence was observed for hypertension (13.2% for both populations), followed by asthma (4.4 and 9.5%, respectively) and diabetes (4.3 and 2.9%, respectively). The age-standardized prevalences of diabetes, COPD, atrial fibrillation, and heart failure, were significantly higher in Nuuk, while seven NCDs including asthma, ischemic heart disease, arthritis urica, psoriasis, hyperthyreosis, hypothyreosis and osteoporosis were significantly higher in the Danish suburb. Conclusion: In contrast to the disease pattern observed in Greenland in the last century, the prevalence of diagnosed NCDs in Nuuk is no longer rare. Thus, the overall prevalence of NCDs in the population of Nuuk is now comparable to or even higher than in the suburb in Denmark. This calls for increased focus on all NCDs in the primary healthcare system in Greenland and adaption of the primary healthcare services to a changed disease spectrum. [ABSTRACT FROM AUTHOR]

Research question: This study aimed to examine how actors across different organizational levels respond to institutional complexity when facilitating elite sport and sport for all. By applying institutional work to understand responses to institutional complexity better, we examined the individual actors' organizational roles and why and how they transformed the complexity in performing day-to-day work. Research methods: Data were collected in a bottom-up approach using qualitative focus groups and in-depth interviews. 149 representatives within Norwegian sport organizations contributed to the study, including coaches, club managers, directors, managers in national sport organizations, and the president of the Norwegian Olympic and Paralympic Committee and Confederation of Sports (NIF) Results and findings: Institutional complexity is differently characterized at the different organizational levels. One common issue across levels is that the institutional complexity of sport for all and elite sport is seen as challenging, especially in the local sport clubs where institutional logics turn into day-to-day activity. The main source of the challenge is unifying the youth players and practitioners' different skills and ambitions, which propagates upwards in the organization. How actors respond to complexity varies within the organizational levels and the different sports. Tensions stemming from complexity are often neglected by the political argument of 'the trickle down and up effects', which to a considerable extent lacks empirical evidence. Implications: We recommend local sport managers prioritize expectation management to counteract a conflict of interests between institutional logics. It is necessary that national governing bodies better align their policies with the interest and organizational capacity of local clubs. [ABSTRACT FROM AUTHOR]

Understanding ethnic variations in body composition is crucial for assessing health risks. Universal models may not suit all ethnicities, and there is limited data on the Inuit population. This study aimed to compare body composition between Inuit and European adults using computed tomography (CT) scans and to investigate the influence of demographics on these measurements. A retrospective analysis was conducted on 50 adults (29 Inuit and 21 European) who underwent standard trauma CT scans. Measurements focused on skeletal muscle index (SMI), various fat indices, and densities at the third lumbar vertebra level, analyzed using the Wilcoxon-Mann-Whitney test and multiple linear regression. Inuit women showed larger fat tissue indices and lower muscle and fat densities than European women. Differences in men were less pronouncehd, with only Intramuscular fat density being lower among Inuit men. Regression indicated that SMI was higher among men, and skeletal muscle density decreased with Inuit ethnicity and age, while visceral fat index was positively associated with age. This study suggests ethnic differences in body composition measures particularly among women, and indicates the need for Inuit-specific body composition models. It highlights the importance of further research into Inuit-specific body composition measurements for better health risk assessment. [ABSTRACT FROM AUTHOR]

The Life Attitudes Schedule-Short Form (LAS-SF) is a measure of suicide proneness featuring various conceptual models. We tested four competing LAS-SF factor structures, as well as construct validity with mental health and suicide metrics. Community dwelling adults (N = 488) completed an online cross-sectional survey. Results supported a four factor (i.e., death-related, health-related, injury-related, and self-related subscales) LAS-SF structure with one higher order factor. Death-related, injury-related, and self-related subscales demonstrated moderate positive associations with mental health and suicidal ideation. Death-related and self-related subscales showed links with suicidal ideation, as well as suicide and depression risk (controlling for other factors). This study is important in highlighting suicide proneness theory may need to be refined. LAS-SF uses include possible risk screening in clinical settings and future focus on the psychological death aspects of the LAS-SF in prospective research. Study limitations include lack of sample diversity and cross-sectional design. [ABSTRACT FROM AUTHOR]

The natural history of symptomatic uncomplicated gallstone disease is largely unknown. We examined the risk of progressing from symptomatic uncomplicated to complicated gallstone disease in a large regional cohort of patients, where disruptions in elective surgical capacities have led to the indefinite postponement of surgery for benign conditions, including cholecystectomies. Patients with radiologically diagnosed incident symptomatic and uncomplicated gallstone disease were identified from outpatient clinics and emergency departments on the Island of Funen, Denmark. The absolute risk of complications (cholecystitis, cholangitis, pancreatitis, acute cholecystectomy for unremitting pain) was calculated using death and elective cholecystectomies as competing risks using the Aalen-Johansen method. Cox proportional hazards regression analysis was used to estimate hazard ratios (HRs) of gallstone complications associated with patient and gallstone characteristics. Two hundred eighty-six patients diagnosed with incident symptomatic, uncomplicated gallstone disease from 1 January 2020 to 1 July 2023 were identified. During 79,170 person-years of observation, 176 (61.5%) patients developed a gallstone-related complication. The 6-, 12- and 24-month risk of developing gallstone-related complications were 36%, 55% and 81%. The risk of developing complications related to common bile duct stones was lowest with larger stones (aHR per millimeter increase = 0.89 (0.82–0.97), p < 0.01), while no covariates were statistically significantly associated with the risk of cholecystitis. Eighty-five (30%) patients underwent elective laparoscopic cholecystectomy, with one patient (1.2%) developing a gallstone-related complication afterward. The risk of developing complications to symptomatic gallstones in a general Scandinavian population is high, and prophylactic cholecystectomy should be considered. [ABSTRACT FROM AUTHOR]

According to many theorists, discrimination either requires a better treated comparator or can occur only if the discriminator belongs to a socially salient group different from that of the discriminatee. Both claims are philosophically important since they have important implications for which account of the moral wrongness of discrimination is correct, e.g., if no comparator is required, the wrongness of discrimination cannot result from treating different people as unequals since the unequal treatment of persons is not an essential feature of discrimination. Most theorists who have written on the topic see their account as articulating the folk concept of discrimination. However, none have subjected their putative articulations thereof to experimental testing. This is what the present study does. Its results are mixed, interesting, and call for further studies. Regarding comparativity, surprisingly, respondents are more disposed to classify a situation as discriminatory when there is no comparator than when there is one. Regarding reflexivity, respondents are more likely to classify our vignettes as involving discrimination when the discriminator is from another socially salient group than the discriminatee as to ethnicity but not when it comes to gender. Hence, non-reflexivity does not appear to be a conceptual requirement on discrimination. Remarkably, our study also shows that the mere reference to a majority, outgroup person in our vignettes makes respondents more likely to classify the vignette as involving discrimination against a minority person, even when the majority group person does not play the role of a comparator. [ABSTRACT FROM AUTHOR]

This article examines how cultural policies focused on Democratisation of Culture and Cultural Democracy are affected by different public administration regimes, namely New Public Management (NPM) and New Public Governance (NPG). The NPM era saw a focus on performance measurement and goal setting in the pursuit of democratizing culture, while the NPG expects cultural institutions to take responsibility for widening access through projects involving non-users and NGOs. Cultural Democracy policies experienced an increase in demands for documented impacts under NPM, while the NPG emphasized participatory decision-making, and for cultural institutions to "do good". The article argues that NPG changes the appearance of instrumentality. In the era of NPG, actors in the field of culture 1) are expected to explore their own potential for innovation, 2) are expected to contribute on equal terms with other public institutions to the solution of society's pressing problems, and 3) experience a trend where cultural work is framed as doing good or creating change. This situation makes it difficult to identify and criticize instrumentality. The NPG conceals the disadvantages of instrumental cultural policy and makes it difficult to question it. The NPG reframes instrumentality as something that should be taken for granted, something positive, and because it is initiated from below, something that is not even recognizable as instrumental cultural policy. [ABSTRACT FROM AUTHOR]

This paper introduces a novel dataset on working-time regulation for 197 territories between 1789 and 2010 to document how working hours have become globally standardised through public policy. Descriptive analysis shows that working-time reforms are global in scope, rare events, sizable once undertaken and tend to reduce hours. Democracies were historically more likely than autocracies to regulate hours, but this is not the case now, and there has never been a large gap in the content of their regulations. Whereas independent states always regulated hours to a greater extent, over half of all dependent states just prior to decolonisation regulated hours with more generous regulations than independent states. Based on these patterns, the paper first makes a methodological plea for more long-term historical studies and, second, sketches two possible explanatory frameworks for working-time reforms. One highlights shocks to the powerbase of antiregulation coalitions; the other highlights international normative change. [ABSTRACT FROM AUTHOR]

SARS-CoV-2 non-structural protein 10 (nsp10) is essential for the stimulation of enzymatic activities of nsp14 and nsp16, acting as both an activator and scaffolding protein. Nsp14 is a bifunctional enzyme with the N-terminus containing a 3′-5′ exoribonuclease (ExoN) domain that allows the excision of nucleotide mismatches at the virus RNA 3'-end, and a C-terminal N7-methyltransferase (N7-MTase) domain. Nsp10 is required for stimulating both ExoN proofreading and the nsp16 2'-O-methyltransferase activities. This makes nsp10 a central player in both viral resistance to nucleoside-based drugs and the RNA cap methylation machinery that helps the virus evade innate immunity. We characterised the interactions between full-length nsp10 (139 residues), N- and C-termini truncated nsp10 (residues 10-133), and nsp10 with a C-terminal truncation (residues 1-133) with nsp14 using microscale thermophoresis, multi-detection SEC, and hydrogen-deuterium (H/D) exchange mass spectrometry. We describe the functional role of the C-terminal region of nsp10 for binding to nsp14 and show that full N- and C-termini of nsp10 are important for optimal binding. In addition, our H/D exchange experiments suggest an intermediary interaction of nsp10 with the N7-MTase domain of nsp14. In summary, our results suggest intermediary steps in the process of association or dissociation of the nsp10–nsp14 complex, involving contacts between the two proteins in regions not identifiable by X-ray crystallography alone. [ABSTRACT FROM AUTHOR]

The objective of this study was to compare outcomes and patient satisfaction, and secondly to compare complication rates between one- and two-level anterior cervical discectomy and fusion (ACDF) for cervical radiculopathy. Data from patients receiving one- or two-level ACDF for cervical radiculopathy at two institutions were prospectively collected and retrospectively analysed. Patients were separated into one-level ACDF and two-level ACDF. Comparison analyses of patient-reported outcome measures (PROMs) comprising Visual Analogue Scale for neck pain (VAS-NP) and arm pain (VAS-AP), Neck Disability Index (NDI), and EQ-5D 3-level version (EQ-5D-3L) were performed between baseline and 1-year follow-up and between groups as well as achievement of minimal clinically important differences (MCID) in PROMs and satisfaction. Additionally, complications were compared between groups. A total of 410 patients (270 one-level and 140 two-level) were included. PROMs improved significantly from baseline to 1-year follow-up (p < 0.001) in both groups. When comparing PROMs between one- and two-level ACDF, a trend towards greater improvement was observed in patients undergoing one-level ACDF, notably in EQ-5D-3L (p = 0.073). Significantly more patients in the one-level group achieved MCID in VAS-NP compared to patients in the two-level group (56% vs 44%, p = 0.025). Two hundred and ninety-six (67%) patients reported to be satisfied, but the one-level group trended to be more satisfied (70% vs. 62%). One-level ACDF further demonstrated a trend of more favourable complication profiles; however, complication rates were low in both groups. The risk of intraoperative complications was 2.4%, postoperative complications in-hospital were 1.2%, and patient-reported postoperative events post-discharge 42%. One- and two-level ACDF are effective procedures for degenerative cervical nerve root compression. Yet, significantly more patients in the one-level group achieved MCID in neck pain compared to patients in the two-level group. [ABSTRACT FROM AUTHOR]

This study examines podcasts as a pedagogical approach to improve principles-level accounting students' perceptions of course engagement and the relevance of accounting. In each podcast, the course instructor interviews a business professional who describes how he/she uses accounting information in the workplace. Students listen to podcasts periodically throughout the course. Survey results indicate that approximately one-half of study participants perceived the podcasts increased their engagement in the course and two-thirds perceived the podcasts helped them better understand the relevance of accounting for business professionals. Results are significantly stronger for accounting majors and participants expecting to earn higher course grades. Results for non-accounting majors and participants with lower grade expectations remain positive. These findings suggest that podcasts may be used to positively influence perceptions of course engagement and the relevance of accounting, particularly among accounting majors and high performing students. [ABSTRACT FROM AUTHOR]

This study was designed to evaluate the classification accuracy of the Memory module for the Inventory of Problems (IOP-M) in a sample of real-world patients. Archival data were collected from a mixed clinical sample of 90 adults clinically referred for neuropsychological testing. The classification accuracy of the IOP-M was computed against psychometrically defined invalid performance. IOP-M ≤30 produced a good combination of sensitivity (.46-.75) and specificity (.86-.95). Lowering the cutoff to ≤29 improved specificity (.94-1.00) at the expense of sensitivity (.29-.63). The IOP-M correctly classified between 73% and 91% of the sample. Given its low cost, ease of administration/scoring in combination with robust classification accuracy, the IOP-M has the potential to expand the existing toolkit for the evaluation of performance validity during neuropsychological assessments. [ABSTRACT FROM AUTHOR]

This study analyzes the impact of the Chicago Alliance for Equity in Computer Science (CAFÉCS) Research Practice Partnership (RPP) on the Chicago Public School (CPS) Office of Computer Science (OCS). Using a qualitative analysis drawing on data from leadership team meetings, published articles and presentations, and evaluation reports from 11 years of the partnership, we utilized a framework developed by the CAFÉCS leadership team to document the impact on district (1) Programs, (2) Research, (3) Organizational Structures, and (4) Policies leading to (5) Equitable Results for students, condensed as PROSPER. In particular, we explore the role of the RPP in supporting a 500% increase in graduating students who completed at least one high school computer science (CS) course between 2016 and 2020 in Chicago Public Schools (CPS). This study adds to the existing literature on assessing the impact of RPPs through the development of the PROSPER Framework, which may be a useful tool to help RPPs examine impacts on partner districts. [ABSTRACT FROM AUTHOR]

To explore the registration of enthesitis among biologic-naïve patients with psoriatic arthritis (PsA) initiating tumour necrosis factor inhibitor (TNFi) treatment across 12 European registries, compare the disease burden and patient-reported outcomes (PROs) between patients with and without enthesitis, and assess the enthesitis treatment response. Demographics, clinical characteristics, and PROs at first TNFi (TNFi-1) initiation (baseline) were assessed in patients with PsA, diagnosed by a rheumatologist, with versus without assessment of entheses and between those with versus without enthesitis. Enthesitis scores and resolution frequency were identified at follow-up. Of 10 547 patients in the European Spondyloarthritis (EuroSpA) Research Collaboration Network initiating TNFi, 1357 underwent evaluation for enthesitis. Eight registries included a validated scoring system for enthesitis. At baseline, 874 patients underwent entheses assessment [Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) 485 patients, Spondyloarthritis Research Consortium of Canada (SPARCC) 389 patients]. Enthesitis was detected by MASES in 170/485 (35%, mean score ± sd 3.1 ± 2.4) and by SPARCC in 236/389 (61%, 4 ± 3.4). Achilles enthesitis was most frequent, by both MASES (unilateral/bilateral 28%/9%) and SPARCC (48%/18%). MASES/SPARCC baseline and follow-up scores for TNFi-1 were available for 100/105 patients. Of these, 63 patients (63%) (MASES) and 46 (43.8%) (SPARCC) achieved resolution of enthesitis. The site-specific enthesitis resolution was overall lower at SPARCC sites (peripheral; 63–80%) than at MASES sites (mainly axial; 82–100%) following TNFi-1. Disease activity and PROs were worse in patients with versus without enthesitis. Entheseal assessments are only registered in a minority of patients with PsA in routine care. When assessed, enthesitis was common, and a substantial proportion demonstrated resolution following treatment with TNFi-1. [ABSTRACT FROM AUTHOR]

Measurement-based care, an evidence-based practice endorsed by the American Psychological Association, is underpinned by routine assessment supporting a data-driven approach to clinical decision making. Nonetheless, there is a need for brief, nonproprietary measures assessing non-symptom-based outcomes. The present study examined the psychometric properties of the Therapy Progress Scale (TPS), a four-item measure assessing clients' perceived treatment progress in multiple life functioning domains. The sample included 36,420 clients (66% female, 55.5% White, 31.5% Racial/Ethnic Minority) receiving outpatient psychotherapy from a practice-research group of private practitioners. The TPS demonstrated a one-factor solution (χ2 (2) = 362.08, RMSEA =.076, CFI =.999, TLI =.996) with high reliability estimate (coefficient α =.87). Additionally, the factor structure was consistent across client gender and race/ethnicity. There were moderate negative correlations with symptom-based measures (i.e. PHQ-9 and GAD-7). Test-retest correlation was also strong. Implications for research and practice are provided. [ABSTRACT FROM AUTHOR]

Patients with cardiac implantable electronic device (CIED) and Staphylococcus aureus bacteraemia (SAB) are at risk of having CIED infection, pocket infection or endocarditis. To avoid treatment failures, guidelines recommend that the CIED should be extracted in all cases of SAB butrecent studies indicate low extraction rates and low risk of relapse. The aim of the study was to describe a Swedish population-based cohort of patients with CIED and SAB, the rate of extraction, and treatment failure measured as recurrent SAB. Patients identified to have SAB in the Karolinska Laboratory database, serving a population of 1.9 million, from January 2015 through December 2019 were matched to the Swedish ICD and Pacemaker Registry. Patients with CIED and SAB were included. Clinical data were collected from medical records. A cohort of 274 patients was identified and 38 patients (14%)had the CIED extracted. Factors associated with extraction were lower age, lower Charlson comorbidity index, shorter time since CIED implantation, and non-nosocomial acquisition, but not mortality. No patient was put on lifelong antibiotic treatment. Sixteen patients (6%) had a recurrent SAB within one year, two in patients subjected to extraction (5%) and 14 in patients not subjected to CIED-extraction (6%). Three of the 14 patients were found to have definite endocarditis during the recurrent episode. Despite a low extraction rate, there were few recurrences. We suggest that extraction of the CIED might be omitted if pocket infection, changes on the CIED, or definite endocarditis are not detected. [ABSTRACT FROM AUTHOR]

To provide an overview of the content and characteristics of face-to-face interventions to encourage enrollment in exercise-based cardiac rehabilitation (CR). Following a published protocol describing the methods, six databases were searched. The search was limited to studies published from January 2000 to December 2021. Two reviewers independently performed study selection and data extraction. 5583 studies were identified and 20 studies with a variety of study designs met the inclusion criteria. Eight studies specified important content in face-to-face interventions to be: Education, problem-solving, support of autonomy, exploring reasons for change, emotional and cognitive support while showing understanding. Studies targeting patients' experiences used motivational interviewing and addressed worries and anticipated difficulties. Intention to attend, CR barriers, practical barriers, exercise self-efficacy, and patients asking questions supported enrollment. Reassurance could lead to nonattendance if patients had a high degree of worry and distress. Face-to-face interventions are important to support patients' enrollment in CR and should integrate a person-centered dialogue exploring reasons for change and providing support to overcome barriers. Focus on the patients' perspectives, the mechanisms of change, and the evaluation of the intervention to inform implementation should be further explored. In-hospital face-to-face interventions support enrollment in cardiac rehabilitation (CR) in patients with ischemic heart disease. This study suggests that individual worries and barriers toward CR should be jointly explored while considering patients' capacity for making choices as well as their vulnerability. Patients should be encouraged to ask questions. A too strong focus on reassurance and problem-solving can impede enrollment. [ABSTRACT FROM AUTHOR]

This article traces Hobbes's account of 'exemplarity' from his early writings to Leviathan. It argues that, by tracking Hobbes's changing views on exemplarity, we get a better grasp on how he construed the effective conditions of an enduring peace in 1651. While these conditions are compatible with the formal structure of sovereignty, they remain distinct from it. I start by inserting Hobbes's early engagement with historiography in the context of the 'crisis of exemplarity' of the late Renaissance. Whereas prior engagement with antiquity had relied on a notion of exemplarity as historical particulars embodying general norms to be imitated in a contemporary setting, a dissatisfaction with this model, characteristic of a revived interest in Tacitus, appears in the sixteenth century. Initially adhering to this 'Tacitean' scheme of political theory, Hobbes ended up abandoning exemplarity as the foundational model of politics in Elements of Law and De cive. However, Leviathan reintroduced the scheme of exemplarity as a strategy of effective government. This strategy is based on a retrieval of the sovereign's appearance as a moral exemplum to be imitated by the subjects. Lastly, I suggest that this change stems from the altered conditions of government at the end of the 1640s. [ABSTRACT FROM AUTHOR]

This special issue consists of four articles, contributed by David Owen; Désirée Lim, Sahar Akhtar and (as co-authors) Mollie Gerver, Miranda Simon, Patrick Lown and Dominik Duell. These contributions address issues related to migration policies with the aim of bringing normative theories of migration and discrimination into dialogue. These theories describe the various types of discrimination inherent in the domestic and global migration systems, as well as assess arguments, pro et contra, about whether these forms of discrimination are permissible. [ABSTRACT FROM AUTHOR]

This is a landmark study, the first to use a listing on a state sex offender registry website as a predictive variable for tracking adult recidivism of male adolescents adjudicated for sex offenses, and the longest to follow a cohort of these youth after discharge from a secure residential treatment program. Upon admission, the sample (N = 145) were assessed by JSORRAT-II and MEGA♪, two contemporary standardized, validated risk assessment tools for assessing youth who have engaged in sexually abusive behavior. They were then followed once discharged for 17.08 years into adulthood (mean follow-up = 14.0 years, SD = 1.71). Recidivism rate was 6.2% (defined as a listing for the subject on the California Megan's Law Sex Offender Registry Website). The study offers a baseline for future studies that use a state sex offender registry website as a predictive variable for recidivism. Shared common denominators of recidivists and non-recidivists were risk level (i.e. most were High Risk or Very High Risk on MEGA♪); and having a history of adverse childhood experiences other than sexual abuse (i.e. child neglect/emotional abuse and exposure to domestic violence). A history of sexual abuse, experienced by twice as many non-recidivists as recidivists, differentiated the sample. Recidivists also had fewer protective factors than non-recidivists, as assessed by the MEGA♪ upon admission to the facility. The mean age of recidivists was younger than non-recidivists, suggesting they may have been removed from their home at an early age, and/or had an early onset of persistent coarse sexual improprieties and/or sexually abusive behaviors that persisted into adulthood. The results highlight the importance of integrating trauma-informed interventions in treatment programs for those individuals who are sexually abusive that have a history of multiple adverse childhood experiences. [ABSTRACT FROM AUTHOR]

In 2020, a 2-month-old ethnically Danish girl was diagnosed with β-thalassemia after presenting with persistent jaundice. The peripheral blood smear showed significant aniso- and poikilocytosis, increased number of reticulocytes and erythroblastosis. Trio analysis of the index patient and both parents was performed by whole-genome sequencing. Here, both parents were found normal, however the analysis revealed an apparently de novo HBB:c.444A > C variant in the child. The child has recently been discharged three months after a successful bone marrow transplantation with a matched sibling-donor. [ABSTRACT FROM AUTHOR]

In the realm of entrepreneurship and rapid international growth, the influence of digital technologies is profound. The sustained growth of Born Digital firms hinges on intricate relational and network dynamics, particularly within the context of digital platforms. This longitudinal empirical research focuses on case firms immersed in project-based activities centered around health apps. Navigating the complex landscape of digital innovation, these firms must strategically engage with established and emerging digital platform networks. To ensure the continual expansion of their digital platforms, digital entrepreneurs are compelled to exhibit a vision advantage and employ effective sensegiving within their network. The empirical findings underscore the necessity for these firms to adopt multiple dynamic strategies, characterized by rhetorical brokerage, to augment their networks for innovation and internationalization. This necessitates an entrepreneurial approach termed 'platformication,' which encapsulates the actions undertaken in the digital platform space. This study contributes with research and implications of platformication. [ABSTRACT FROM AUTHOR]

Mental health issues are common among patients with chronic physical conditions. This study aims to evaluate the feasibility of the Healthy Mind intervention, a general practice-based programme that provides problem-solving therapy (PST) to patients with poor mental well-being and type 2 diabetes (T2D) and/or ischaemic heart disease (IHD). A one-arm feasibility study was conducted in three general practices in the Central Denmark Region. Eight healthcare providers from the included general practices underwent a two-day course to acquire PST skills. Screening for poor mental health was carried out at the annual chronic care consultation for T2D or IHD, and PST sessions were offered to patients on indication of poor mental health. Nine patients received PST. Semi-structured interviews with eight healthcare providers and six patients were conducted. Data were analysed deductively focusing on appropriateness, acceptability and fidelity of the intervention. The intervention was considered appropriate for the patient group and the general practice setting. The providers acknowledged PST as a valuable tool for managing psychological issues in general practice, and the patients perceived PST as an effective and tangible treatment. Since practice nurses' schedules were generally better suited for longer consultations, they were often the preferred intervention providers. The intervention was largely delivered as intended. However, the GPs generally expected patients to prefer a more directive approach, which sometimes challenged their role as facilitator and guide. The Healthy Mind intervention was found to be feasible, and the results support proceeding to a full-scale evaluation trial. Patients with type 2 diabetes and/or ischaemic heart disease often experience poor mental well-being, revealing a shortage of general practice-based interventions targeting this issue. This study evaluates the feasibility of a problem-solving therapy intervention in general practice for patients with poor mental health and type 2 diabetes and/or chronic ischemic heart disease. Both patients and healthcare providers regarded problem-solving therapy as an acceptable intervention for managing psychological issues in general practice. Healthcare providers preferred practice nurses as the providers of problem-solving therapy since their schedules were often more suitable for longer consultations. In problem-solving therapy, the provider is expected to take a facilitating and guiding role, but GPs sometimes struggled remaining in this role due to a preconceived anticipation that patients expected them to take a more directive approach. [ABSTRACT FROM AUTHOR]

To update a previous review of psychometric properties of performance-based outcome measurement instruments (PerFOMs) for task performance in the context of meal activity of older adults (≥65 years) with suspected oropharyngeal dysphagia (OD). Systematic searches were conducted in PubMed, CINAHL, EMBASE, SCOPUS, and Web of Science. Studies on PerFOMs that covers items reflecting skills in the pre-oral, oral, and pharyngeal stages of ingestion during meals were included. Two review authors independently screened, extracted, and evaluated the methodological rigour and quality of the reported psychometric properties in the included studies using the guidelines of the COnsensus-based Standards for the Selection of health Measurement INstruments (COSMIN). Twenty-three articles featuring nine original PerFOMs and five translated versions were included. PerFOM development and content validity were rated with inadequate or doubtful methodological quality across all studies. The quality of the evidence across the additional psychometric properties of the PerFOMs was very low for two, ranged from very low to moderate for six, and from very low to high for five. There is limited evidence of the psychometric properties of available PerFOMs for measuring task performance during meals in older adults with OD, and further validation is warranted. Assessing the mealtime performance of older adults with oropharyngeal dysphagia (OD) provides important information. Performance-based outcome measurement instruments (PerFOMs) need to be valid and reliable. Clinicians need to be careful when choosing PerFOMs to assess the mealtime performance of older adults with OD as there is insufficient evidence on the quality of available instruments. Established guidelines and standards should be used when developing and investigating psychometric properties of PerFOMs assessing mealtime performance of older adults with OD. [ABSTRACT FROM AUTHOR]

Entrapment and defeat are empirically-supported suicide risk factors. Their measurement is the subject of some debate, however. Also, limited work exists examining sexual and gender minority (SGM) differences in these suicide risk factors despite overall elevated rates of suicidal thoughts and behaviors (STBs) for SGM persons. The present study examined (1) entrapment and defeat differences by sexual orientation and gender identity, (2) factor structure and criterion validity of the Entrapment Scale (E-Scale) and the Defeat Scale (D-Scale), and (3) measurement invariance by sexual orientation (subsamples were too small for gender identity). A sample of 1,027 adults living in the United Kingdom completed a cross-sectional online questionnaire assessing mental health. Analysis of Variance and Kruskal-Wallis testing revealed: (1) all sexual minority (i.e., gay/lesbian, bisexual, and other SM) persons reported higher internal and external entrapment, defeat, and suicidal ideation compared to their heterosexual counterparts, and; (2) gender minority (i.e., transgender and gender diverse) persons reported higher internal and external entrapment, defeat, and suicidal ideation compared to cisgender persons. Supported by suicide theory, confirmatory factor analysis showed modest support for a two-factor E-Scale (internal and external), and a one-factor D-Scale. All entrapment and defeat scores displayed significant moderate positive correlations with suicidal ideation. E- and D-scale scores displayed high intercorrelation, tempering confidence in conclusions regarding the facture structure findings. Item threshold-level responding varied by sexual orientation for the D-Scale but not the E-Scale. Results are discussed with respect to suicide theory and measurement, public health, and clinical practice. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the prevalence of cochlear-facial dehiscence (CFD) and other radiographical pathologies in ears with facial nerve stimulation (FNS) from a cochlear implant (CI). Methods: Retrospective case–control study of 27 patients with CI and FNS on either ear (study group) and 27 patients without FNS, matched for age, sex and type of electrode array (control group). Preoperative CT scans of all 108 ears were re-evaluated. Subanalyses included comparisons between the study and control groups and associations between FNS and radiographic pathologies. Results: CFDs were detected in 20 of 54 ears (37%) in the study group and in 3 of 54 ears (6%) in the control group (P < 0.001). The corresponding numbers of otosclerosis were 10 (18%) and 0 (P = 0.011) and of developmental anomalies 16 (30%) and 8 (15%) (not significant). FNS was present in 33 ears in the study group, of which 14 (42%) had a CFD. FNS was absent in six ears with CFD and CI, four of which contralateral to an ear with FNS. Eight of 14 ears with FNS and CFD had a lateral electrode array and six had a perimodiolar electrode array. We found no association between the presence of CFD and stimulation thresholds for FNS. The adjusted odds ratio for developing FNS in the presence of a CFD was 9.9 (95% CI 2.7–36.0). Conclusions: CFD was the most common radiographic pathology in ears with FNS, with a 10-fold increased risk of FNS. To avoid CI-related FNS, preoperative CT scan and awareness of typical dehiscence symptoms are strongly recommended. [ABSTRACT FROM AUTHOR]

Tyrosine kinase inhibitors (TKIs) have revolutionized survival rates of chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) and replaced hematopoietic stem cell transplantation (hSCT) as the key treatment option for these patients. More recently, the so-called Philadelphia chromosome-like (Ph-like) ALL has similarly benefitted from TKIs. However, many patients shift from the first generation TKI, imatinib, due to treatment-related toxicities or lack of treatment efficacy. A more personalized approach to TKI treatment could counteract these challenges and potentially be more cost-effective. Therapeutic drug monitoring (TDM) has led to higher response rates and less treatment-related toxicity in adult CML but is rarely used in ALL or in childhood CML. This review summarizes different antileukemic treatment indications for TKIs with focus on imatinib and its pharmacokinetic/-dynamic properties as well as opportunities and pitfalls of TDM for imatinib treatment in relation to pharmacogenetics and co-medication for pediatric and adult Ph+/Ph-like leukemias. TDM of imatinib adds value to standard monitoring of ABL-class leukemia by uncovering non-adherence and potentially mitigating adverse effects. Clinically implementable pharmacokinetic/-dynamic models adjusted for relevant pharmacogenetics could improve individual dosing. Prospective trials of TDM-based treatments, including both children and adults, are needed. [ABSTRACT FROM AUTHOR]

Cardiac surgery is required in up to half of the patients with infective endocarditis (IE). Positive valve cultures have been associated with higher in-hospital mortality. The aims were to identify risk factors for positive valve cultures and its relation to outcome. Patients subjected to heart valve cultures due to surgery for IE in Skåne University Hospital, Lund, between 2012 and 2021 were identified through microbiology records. Risk factors for positive valve cultures and information on mortality and relapse were retrieved through medical records. Univariable and multivariable logistic regressions were performed. A total of 345 episodes with IE in 337 patients subjected to cardiac surgery were included and valve cultures were positive in 78 (23%) episodes. In multivariable logistic regression, preoperative fever (adjusted odds ratio (AOR) 2.6, 95% confidence interval (CI) 1.2–5.6, p = 0.02), prosthetic heart valve (AOR 3.3, CI 1.4–7.9, p = 0.01), a single affected valve (AOR 4.8, CI 1.2–20, p = 0.03), blood culture findings of S. aureus, enterococci, or coagulase negative staphylococci compared to viridans streptococci (AOR 20–48, p < 0.001), and a shorter duration of antibiotic treatment (p < 0.001), were associated to positive valve culture. One-year mortality was 13% and a relapse was identified in 2.5% of episodes. No association between positive valve cultures and one-year mortality or relapse was identified. Positive valve cultures were associated to short preoperative antibiotic treatment, IE caused by staphylococci, preoperative fever and prosthetic valve but not to relapse or mortality. [ABSTRACT FROM AUTHOR]

What do we owe to the lazy? On the assumption that the lazy are a paradigmatic case of people who are worse off, when they are through a fault, or choice, of their own, one might suspect that the answer is: not very much. This article shows that this suspicion is simple-minded. Four notions of laziness are distinguished. It is then shown that these notions differ – even from a luck egalitarian perspective – in ways bearing on the question of what is owed to the lazy. It is claimed that in some – but not all – cases, being lazy grounds a claim to compensation rather than forming a ground for withholding it. [ABSTRACT FROM AUTHOR]

AbstractObjectiveMethodResultsConclusions\nHIGHLIGHTSSuicide remains a public health problem within the United Kingdom (UK) and globally. Impulsivity is a key risk factor within the Integrated Motivational-Volitional Model (IMV) of Suicide warranting further study. The current study applied a multi-dimensional impulsivity framework (UPPS-P) to differentiate suicidality subgroups within an IMV framework (i.e., no suicidal behavior, suicidal ideation only, and suicide attempt). Impulsivity subscales were evaluated as moderators of the suicidal ideation-future suicide attempt link.Adults living in the UK (N = 1027) completed an online survey addressing demographics, impulsivity, psychological distress, and lifetime suicidal behavior. We used analysis of variance (ANOVA) and linear regression with simple slopes analyses to investigate study objectives.Data analyses revealed that: (1) four impulsivity subtypes (negative urgency, positive urgency, lack of premeditation, sensation-seeking) differentially distinguished suicidal behavior groups; (b) negative urgency, positive urgency, and lack of premeditation were meaningfully associated with suicide outcomes, and (c) negative urgency served as a moderator of the suicidal ideation-future attempt link.Urgency, regardless of positive or negative valence, is important for understanding differences in lifetime suicidal behavior. Sensation-seeking may play a protective role for direct suicidal behavior. Negative urgency may be the most prominent aspect of impulsivity when considered as an IMV moderator. Findings are contextualized with respect to impulsivity and IMV frameworks. Clinical implications involve accounting for negative urgency in suicide risk assessment and intervention.Urgency matters when differentiating persons with lifetime suicidal behavior.Negative urgency may be the most robust impulsivity IMV moderator.Suicide theory and prevention should account for the role of negative urgency.Urgency matters when differentiating persons with lifetime suicidal behavior.Negative urgency may be the most robust impulsivity IMV moderator.Suicide theory and prevention should account for the role of negative urgency. [ABSTRACT FROM AUTHOR]