1. Pregnancy outcome in patients with a medical history of immunoglobulin A vasculitis: a case–control study.
- Author
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Besse, M-C, Perrotin, F, Aouba, A, Gallou, S, Karras, A, Pillebout, E, Urbanski, G, Allain, J-S, Merlot, C, Humbert, S, Ramdani, Y, Ferreira-Maldent, N, Maillot, F, and Audemard-Verger, A
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PREGNANCY outcomes , *ECLAMPSIA , *VASCULITIS , *CASE-control method , *CESAREAN section , *TREATMENT effectiveness - Abstract
Data on obstetric outcomes in patients with a history of immunoglobulin A vasculitis (IgA-V) are lacking. The aim of this study was to assess maternal, neonatal, and vasculitis outcomes during pregnancy. We conducted a French retrospective case–control study. Pregnancies of patients with a history of IgA-V (cases) were retrospectively studied and compared to pregnancies in women who developed IgA-V after their pregnancies and to pregnancies in healthy women (controls). Twenty-six pregnancies in patients with a history of IgA-V were included and compared to 15 pregnancies in women who later developed IgA-V and 52 pregnancies in healthy women. Both gestational hypertension and pre-eclampsia were more frequent in the case group than in the other groups (23% vs 0% vs 0%, p < 0.01; 12% vs 7% vs 0%, p = 0.04). Hypertensive disorder of pregnancy occurred more frequently in patients with pre-existing kidney disease (78% vs 12%, p < 0.01). Caesarean section was more often performed in the case group than in the other groups (27% vs 0% vs 10%, p = 0.04). No foetal loss or maternal deaths occurred. There were no differences in delivery term or birth weight. No vasculitis flares were observed during pregnancy. Women with a history of IgA-V appear to be at higher risk for gestational hypertension and pre-eclampsia, especially in cases with renal involvement; however, both mother and newborn outcomes appear to be favourable. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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