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Purpose: To quantify and compare the foveal avascular zone (FAZ) and the whole, parafoveal and foveal vessel density of superficial (SCP) and deep capillary plexus (DCP) in amblyopic eyes of adults and age-matched controls. Methods: This cross-sectional study involved 52 eyes from 34 subjects aged 18 to 45 years. Optical coherence tomography angiography (OCTA) was performed to all participants and SCP, DCP and FAZ were evaluated. SPSS (Statistical Package for the Social Sciences) 23 was used for data analysis. Results: Eighteen of 34 subjects (52,9%) were amblyopic and 16 (47,1%) of them controlled. Mean subject age was 31.2 years in the amblyopia group and 28.3 years in the control group. The mean FAZ measurements were 0.28 ± 0.08 in amblyopic eyes, 0.29 ± 0.08 in fellow eyes and 0.3 ± 0.11 in control eyes. The whole, foveal and parafoveal vessel density of SCP in both 3x3-mm and 6x6-mm scans were not statistically different in amblyopic eyes, fellow eyes and control eyes. In 6x6-mm scans, the whole, and parafoveal vessel density of DCP were significantly lower in amblyopic eyes than controls. There was no statistically significant difference in 3x3-mm scans about DCP. Conclusion: OCTA revealed lower vessel density in DCP of amblyopic eyes than fellow eyes and controls in adults. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate qualitative optical coherence tomography (OCT) findings and quantitative parameters, such as central macular thickness (CMT) and subfoveolar choroidal thickness (SFCT), in the eyes of preeclamptic women. Methods: The prospective, comparative, cross-sectional study included 52 eyes of 52 preeclamptic (PE) women and 54 eyes of 54 healthy pregnant women in their second or third trimester. Central macular thickness (CMT), subfoveolar choroidal thickness (SFCT), were evaluated in relation to presence of positive qualitative OCT findings such as any subretinal or intraretinal fluid, irregularity on the external photoreceptor and RPE layer, or presence of pigment epithelial detachment. Results: No significant difference was detected between the PE group and the healthy pregnant group with respect to CMT (P= 0.905), but the mean SFCT value was significantly higher in the PE group than in the healthy pregnant group (391.4 ± 71.1 vs 331.5 ± 53.8 µm, P < 0.001). Receiver operating characteristic analysis revealed that SFCT could predict qualitative OCT findings in preeclampsia, and the optimal cut-off value was 400 µm with a sensitivity of 91% and a specificity of 85%. Conclusion: The eyes of preeclamptic women, and particularly those with positive qualitative OCT findings, showed significantly increased SFCT values. A preliminary cut-off level of 400 µm for SFCT is proposed for the prediction of severe preeclampsia. [ABSTRACT FROM AUTHOR]

Additionally, as stated in our paper, preeclampsia patients - particularly those with severe preeclampsia - are not easily able to be mobilized from the obstetric clinic to the Optical Coherence Tomography (OCT) room once they are stabilized. Patients enrolled in OCT assessment had already been put on a number of antihypertensive medications for many hours as well. Therefore, we believe that the effect of diurnal variation on choroidal thickness under that perturbed circumstance is likely to be negated or masked which needs approval or disapproval by further studies. [Extracted from the article]