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High-mobility group box 1 ( HMGB1) has recently been reported to be involved in proinflammation and tissue repair. Therefore, we hypothesized that HMGB1 is released into the bloodstream after eccentric exercises or prolonged endurance activities. Blood samples from 11 participants that performed 100 drop to vertical jumps ( DVJ) and from 10 participants that took part in the 1200-km 'Paris-Brest-Paris' bicycle race ( PBP) were tested for HMGB1 and creatine kinase ( CK) levels. CK increased after both DVJ ( pre: 150.6 +/- 81.5 U/L; post: 188.8 +/- 95.5 U/L 8 h: 790.5 +/- 346.4 U/L) and PBP ( pre: 81.3 +/- 36.4 U/L; post: 725.2 +/- 229.5 U/L; 12 h: 535.8 +/- 188.6 U/L), indicating membrane damage. However, HMGB1 plasma levels remained below the detection limit ( 78 pg/mL) of the applied enzyme-linked immunosorbent assay kit for all blood samples analysed. That is, neither high intensity eccentric exercises ( DVJ) nor prolonged endurance events ( PBP) seemed to affect HMGB1 levels in blood at selected time points.