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2020 European Meeting of the International Society for Medical Publication Professionals (ISMPP), 21-22 January 2020, London, UK. 18 About us. Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19. Impact of requirements to register and report results of all clinical trials: what is being p... Funding OPEN Health Group The impact of the increased need for digital activities due to the COVID-19 pandemic: a surve... Funding OPEN Health Group Footnotes 1 Encored poster at the 17th Annual Meeting of ISMPP. 38 Baral R, White M, Vassiliou VS. Effect of renin-angiotensin-aldosterone system inhibitors in patients with COVID-19: a systematic review and meta-analysis of 28,872 patients. [Extracted from the article]

This study evaluated early and frequent seated breaks from standing work to reduce low back pain (LBP) in known pain developers (PD). Twenty-four participants, classified as either PD or non-PD during a separate 2-hour standing session, performed 124 minutes of standing work with seated breaks at a 3:1 stand-sit ratio with increasing durations from 3:1 minute to 48:16 minutes. Back pain and spine posture measures showed no differences between PD and non-PD. Females had greater left glutaeus medius activation (8.4%MVC) than males (4.5%MVC) and greater glutaeus medius co-contraction. This protocol was successful at reducing LBP in PD to the level of non-PD, with mean pain scores (13 mm) only slightly exceeding the clinical LBP threshold of 10 mm. Early and frequent breaks within the first hour of standing work appear to be an effective solution to reduce the LBP that often occurs at the beginning of standing work. Practicioner Summary: Sit-stand workstations may be an effective solution to reduce static occupational low back postures. This experimental study demonstrated that early and frequent seated breaks from standing work may be an effective solution to reduce tissue aggravation that often occurs within the first 45 minutes of a standing work exposure. Abbreviations: LBP: low back pain; PD: pain developer; NPD: non-pain developer; VAS: visual analog scale; EMG: electromyography; LES: lumbar erector spinae; TES: thoracic erector spinae; GMD: glutaeus medius; IOB: internal oblique; MVC: maximum voluntary contraction; CCI: co-activation coefficient; FDA: functional data analysis [ABSTRACT FROM AUTHOR]

Axial twisting exposures have been repeatedly identified as a risk factor for occupational low back pain and injury, but there is a need for an improved understanding of the role of axial twist magnitude and associated joint moment as modifiers of the cumulative load tolerance of intervertebral joints. The purpose of this study was to mathematically characterise the relationship between axial twist motion magnitudes and the cumulative load tolerance of porcine cervical functional spinal units. Twenty-four porcine functional spinal units were fixed in a mechanical testing system under compressive load (15% of compressive tolerance) and in a neutral flexion-extension posture. Specimens were axially twisted to 5, 7.5, 10, 12.5, 15 or 17.5 degrees at 1 Hz until failure or 21,600 total cycles. Cumulative applied axial twist moment was recorded, and exponential functions were fit to the twist magnitude-cumulative twist moment measures. Weighting-factor functions for cumulative axial twist moment injury risk were developed based on absolute axial twist magnitude and twist normalised to maximum range of motion. While caution should be used in extrapolating these findings to human evaluation, a developed non-linear weighting-factor model has potential for use in assessment of cumulative axial twist injury risk in occupational tasks. [ABSTRACT FROM AUTHOR]

Cervical spine flexion is a common posture for those using computers, tablets, and smartphones; the latter being dubbed 'text-neck' in recent years. Coincidentally, flexion has been flagged as a significant mechanical risk factor for the development of chronic neck pain. Unfortunately, few modelling endeavours have attempted to quantify the intervertebral joint loads throughout the cervical spine in flexion, while still accounting for muscular activation. Eight healthy male subjects undertook five trials beginning in a neutral posture, flexed to 45 degrees, and returned to a neutral posture. 3 D head-trunk angles and surface electromyography from 10 neck muscles (5 bilaterally) were used as inputs into an inverse dynamic cervical spine model based on a 50th percentile male to compute the compression and anteroposterior (AP) shear forces for this flexion task. In general, compression increases cranially to caudally throughout the cervical spine, but levels off at the C5-C6 level. Conversely, in a neutral posture, there is a constant 18 N of anterior shear at each joint level. Compression increased twofold throughout the cervical spine with flexion, whereas anterior shear increased fourfold in the upper cervical spine and dramatically decreased caudally. The dramatic change in joint kinetics provides some mechanical evidence for the role of posture and interplay with muscle activity in the development of chronic neck pain. Results from this study can reinforce the need for appropriate workstation and monitor configurations and support the increased loading hypothesised to occur in 'text neck' postures. Practitioner summary: The purpose of this investigation was to quantify the compression and shear forces in the neck in 45 degrees of flexion compared to neutral. Flexion increased compression throughout the cervical spine 1.6-fold compared to a neutral posture. In the upper cervical spine, AP-shear increased four-fold compared to neutral. Abbreviation: AP: anteroposterior [ABSTRACT FROM AUTHOR]

A postural evaluation of commercial licensed truck drivers was conducted to determine the ergonomic benefits of a truck seat prototype in comparison with an industry standard seat. Twenty commercially licensed truck drivers were recruited to perform a 90-min driving task. Postures were assessed using accelerometers and a backrest and seat pan pressure mapping system. Subjective discomfort measurements were monitored using two questionnaires: ratings of perceived discomfort (RPD) and the automotive seating discomfort questionnaire (ASDQ). Participants reported significantly higher discomfort scores when sitting in the industry standard seat. Participants sat with more lumbar lordosis and assumed a more extended thoracic posture when seated in the prototype. Pairing the gluteal backrest panel with the adjustable seat pan also helped reduce the average sitting pressure on both the seat pan and the backrest. The prototype provided several postural benefits for commercially certified truck drivers, as it did for a young and healthy population. [ABSTRACT FROM AUTHOR]

A postural evaluation during a prolonged driving task was conducted to determine the ergonomic validity of a new freely adjustable truck seat prototype. Twenty participants were recruited to perform two 2-h simulated driving sessions. Postures were assessed using motion capture, accelerometers and pressure pads. Subjective discomfort was also monitored in 15-min increments using ratings of perceived discomfort (RPD) and the Automotive Seating Discomfort Questionnaire. Participants had a more neutral spine posture during the first hour of the drive and reported lower RPDs while sitting in the prototype. Pairing the gluteal backrest panel with the adjustable seat pan helped reduce the average sitting pressure. The industry-standard truck seat may lead to the development of poor whole body posture, and the proposed ergonomic redesign of a new truck seat helped improve sitting posture and reduce perceived discomfort. Practitioner Summary:A new freely adjustable truck seat prototype was compared to an Industry standard seat to assess hypothesised improvements to sitting posture and discomfort for long haul driving. It was found that the adjustable panels in the prototype helped promote spine posture, reduce sitting pressure and improved discomfort ratings. [ABSTRACT FROM PUBLISHER]

Police officers are at high risk for developing musculoskeletal injuries. This study aimed to determine differences in physical demands of patrol officers during day shifts and night shifts. Sixteen participants were recruited (10 males, 6 females) for in-vehicle observation over one full day shift and one full night shift. Dynamic pressure distribution when seated in the vehicle was assessed and compared between the first and last parts of each shift. Activity characterization and postural analyses were conducted from video that was recorded continuously for the duration of each shift to determine time spent in each task and corresponding postures. Postural analysis and cumulative joint loads were used to identify higher-risk tasks. Several activities caused the officers to adopt non-neutral postures of the neck, shoulders and back. Future work needs to focus on modifying the interior of the vehicle, as well as decreasing exposure time to activities resulting in non-neutral postures. [ABSTRACT FROM PUBLISHER]

This study sought to compare and validate baseball pitching mechanics, including joint angles and spatiotemporal parameters, from a single camera markerless motion capture solution with a 3D optical marker-based system. Ten healthy pitchers threw 2–3 maximum effort fastballs while concurrently using marker-based optical capture and pitchAITM (markerless) motion capture. Time-series measures were compared using R-squared (r2), and root mean square error (RMSE). Discrete kinematic measures at foot plant, maximal shoulder external rotation, and ball release, plus four spatiotemporal parameters were evaluated using descriptive statistics, Bland-Altman analyses, Pearson’s correlation coefficients, p-values, r2, and RMSE. For time-series angles, r2 ranged from 0.69 (glove arm shoulder external rotation) to 0.98 (trunk and pelvis rotation), and RMSE ranged from 4.37° (trunk lateral tilt) to 20.78° (glove arm shoulder external rotation). Bias for individual joint angle and spatiotemporal parameters ranged from −11.31 (glove arm shoulder horizontal abduction; MER) to 12.01 (ball visible). RMSE was 3.62 m/s for arm speed, 5.75% height for stride length and 21.75 ms for the ball visible metric. pitchAITM can be recommended as a markerless alternative to marker-based motion capture for quantifying pitching kinematics. A database of pitchAITM ranges should be established for comparison between systems. [ABSTRACT FROM AUTHOR]