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MT-3724 is an engineered direct-kill immunotoxin comprised of a CD20-specific scFv fused to a Shiga-like toxin subunit. In this phase IIa study, eight patients with relapsed diffuse large B-cell lymphoma were treated with MT-3724 combined with gemcitabine and oxaliplatin (GEMOX). The objective response rate was 85.7%, with a median duration of response of 2.2 months. The 12-month overall survival and progression-free survival were 71.4% and 28.6%, respectively. Two patients experienced grade 2 capillary leak syndrome (CLS). Combination therapy with MT-3724 and GEMOX demonstrated an early efficacy signal but was limited by the incidence of CLS. [ABSTRACT FROM AUTHOR]

Joint and muscle pain, including arthralgia, myalgia, and musculoskeletal pain, are among the common adverse events (AEs) reported for ibrutinib, a once-daily Bruton's tyrosine kinase inhibitor approved for the treatment of various B-cell malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). This pooled analysis from nine clinical trials of ibrutinib in CLL and MCL (N = 1178) evaluated patterns of these AEs. Any grade arthralgia, myalgia, and musculoskeletal pain occurred in 18%, 10%, and 6% of patients, respectively. AEs were primarily low-grade (grade 1/2: 97‒99%) and occurred during the first year of treatment; most resolved (67%–80%) at first occurrence. Few (<5%) patients required ibrutinib dose modification; no patients discontinued ibrutinib due to these AEs. Among patients evaluated for concomitant medication use, all those receiving concomitant medications after the first AE occurrence experienced AE resolution. These data suggest that these AEs were not treatment-limiting during ibrutinib therapy. [ABSTRACT FROM AUTHOR]

Collaboration is a proven approach to building agreement and resolving conflict over natural resource and environmental issues. This article moves beyond this conclusion and explores the degree to which collaboration—particularly citizen-driven collaboration—offers an alternative theory and practice of democracy applied to the governance of natural resources. Using complexity theory, we argue that collaboration should be considered as one species within the ecology of democracy, which also includes direct, representative, participatory, and deliberative forms. Collaborative democracy is defined as citizen-initiated processes that emerge organically outside the established system of public decision-making. While this form of democracy faces a number of challenges in theory and practice, it tends to result in outcomes that are well-informed and widely supported—largely because people with a stake in the issues being addressed play a central role in framing the problems and solutions. Natural resource managers can be more effective by understanding the complexity of the democratic environment within which they operate. [ABSTRACT FROM PUBLISHER]

The growing interest in community-based collaboration (CBC) has provoked both enthusiasm and skepticism. This article sheds some light on the claims of both proponents and skeptics by presenting data on nearly 50 cases of CBC on federal lands and resources in the Rocky Mountain West. The findings indicate that participants are generally satisfied with the process and outcomes of CBC; CBC tends to open and inclusive of all interests, viewpoints, and stakeholders; CBC fosters informed decision making; CBC is efficient in terms of time and money; CBC produces valuable outcomes; CBC is often better than its alternatives; and CBC is slowly realigning the roles of citizens and public officials. This article also offers some insights on evaluating collaboration. [ABSTRACT FROM AUTHOR]

Disputes over land use are inevitable. Two recent studies demonstrate that negotiation and mediation can effectively resolve such disputes on an ad hoc, case-by-case basis. Given this evidence, and the reality that disputes over land use in many communities are increasingly chronic and ongoing, it is time to move beyond the ad hoc use of negotiation and mediation and incorporate collaborative methods throughout the land use decision-making process. [ABSTRACT FROM AUTHOR]