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The first harvest of Humulus lupulus (var. Cascade) in Brazil in 2016 originated as an aromatic hop that nowadays is gaining attention from the brewery industry. However, the chemical composition and the properties of this hop have not been well documented to date. In this study, the chemical profile of the phenolic compounds and essential oils of Cascade hops produced in Brazil (BH) and the USA (UH) was determined. The major phenolic compounds identified by LC-ESI-MS-MS in BH and UH were protocatechuic acid, isoquercitrin, and ferulic acid (4.18–11.39; 2.44–4.90; and 1.45–4.48 mg 100 g−1, respectively). The profile of essential oils was shown to differ between the two samples. The compounds trans-β-farnesene (20.60%), β-selinene (18.78%), myrcene (16.57%), and α-selinene (16.22%) were the main compounds in the BH essential oil, while the essential oil of UH showed a high content of α-humulene (35.35%), myrcene (22.35%), β-caryophyllene (12.81%), and trans-β-farnesene (10.59%). A higher antioxidant activity (by DPPH and ABTS) was observed for hop extracts when compared to the essential oils. The results indicated that the Brazilian hop sample analyzed had higher radical scavenging when compared to an American hop sample (associated with its bioactive compound composition). The Cascade hop from Brazil appears to be a high-quality raw material showing significant potential for future industrial applications. [ABSTRACT FROM AUTHOR]

Objective: To assess the feasibility and safety of a physiotherapy protocol applied to pregnant women with preeclampsia.Methods: Randomized, controlled, single-blind feasibility study, with 24 hospitalized pregnant women with preeclampsia. The intervention group received one session of the physiotherapy. The control group remained under the routine care of the hospital. The primary outcomes were Doppler velocimetry, cardiotocography, and maternal-fetal hemodynamics. Secondary outcomes were pain and anxiety assessed before and after the interventions. A mixed effects linear regression model was used, and the data were compared with the level of significance at 5%.Results: The baseline characteristics of the participants were homogeneous between groups. Resistance index of the Middle Cerebral Artery (MAC) and Umbilical Artery (UA) and cardiotocography did not change significantly. The systolic blood pressure (SBP) increased 4.90 mmHg in the control group and 0.22 mmHg in the intervention group. The diastolic blood pressure (DBP) increased 1.34 mmHg in the control group and decreased 0.40 mmHg in the intervention group. The middle bood pressure (MBP) increased 4.66 mmHg in the control group while there was a decrease of 0.09 mmHg in the intervention group, without statistical difference. Heart rate (HR) decreased 0.94 bpm in the control group; whereas, in the intervention group, there was an increase of 6.30 bpm. The pain reduced clinically 2 points after the intervention. The anxiety reduced clinically in both the groups (-1.26 in the intervention group and -2.17 in the control group).Conclusion: The protocol applied in the intervention group is feasible and safe for both mother and fetus. Both groups showed clinical reduction in the levels of anxiety; whereas, pain was clinically reduced in the intervention group. [ABSTRACT FROM AUTHOR]