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Your search keyword '"MULLENS, Wilfried"' showing total 25 results
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25 results on '"MULLENS, Wilfried"'

5. Economic implications of adding a novel algorithm to optimize cardiac resynchronization therapy: rationale and design of economic analysis for the AdaptResponse trial.

Author

Filippatos, Gerasimos, Lu, Xiaoxiao, Tsintzos, Stelios I., Gold, Michael R., Mullens, Wilfried, Birnie, David, Hersi, Ahmad S., Kusano, Kengo, Leclercq, Christophe, Fagan, Dedra H., and Wilkoff, Bruce L.

Abstract

Although cardiac resynchronization therapy (CRT) has proven beneficial in several randomized trials, a subset of patients have limited clinical improvement. The AdaptivCRT algorithm provides automated selection between synchronized left ventricular or biventricular pacing with optimization of atrioventricular delays. The rationale and design of the economic analysis of the AdaptResponse clinical trial are described. The costs associated with HF hospitalization are substantial and are compounded by a high rate of readmission. HF hospitalization payments range from $1,001 for Greece to $12,235 for US private insurance. When examining the breakdown of HF-related costs, it is clear that approximately 55% of the hospitalization costs are directly attributable to length of stay. Notably, the mean costs of a CRT patient in need of a HF-related hospitalization are currently estimated to be an average of $10,679. The economic analysis of the AdaptResponse trial has two main objectives. The hospital provider objective seeks to test the hypothesis that AdaptivCRT reduces the incidence of all-cause re-admissions after a heart failure admission within 30 days of the index event. A negative binomial regression model will be used to estimate and compare the number of readmissions after an index HF hospitalization. The payer economic objective will assess cost-effectiveness of CRT devices with the AdaptivCRT algorithm relative to traditional CRT programming. This analysis will be conducted from a U.S. payer perspective. A decision analytic model comprised of a 6-month decision tree and a Markov model for long term extrapolation will be used to evaluate lifetime costs and benefits. AdaptivCRT may offer improvements over traditional device programming in patient outcomes. How the data from AdaptResponse will be used to demonstrate if these clinical benefits translate into substantial economic gains is herein described. [ABSTRACT FROM AUTHOR]

Published
2020
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24. A critical review on telemonitoring in heart failure.

Author

Gurné, Olivier, Conraads, Viviane, Missault, Luc, Mullens, Wilfried, Vachiery, Jean-Luc, Van Mieghem, Walter, Droogne, Walter, Pouleur, Anne-Catherine, Troisfontaine, Pierre, Huez, Sandrine, Nellessens, Eric, Peperstraete, Béatrice, Blouard, Philippe, Vanhaecke, Johan, and Raes, David

Published
2012
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