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Endometrial cancer (EC) is a common gynecological malignancy and its mortality has been increasing in the last twenty years. A growing body of evidence suggests that circulating tumor cells (CTCs) may provide a more complete tumor profile, facilitate the understanding of the molecular mechanism and individual management of EC patients. In this review, we presented the presence and clinical applications of CTCs and disseminated tumor cells (DTCs) in EC, particularly for EC prognosis and management, also highlighted the diagnostic value of tumor cells in urine of EC patients, aim to help researchers better focus on their study in this field. [ABSTRACT FROM AUTHOR]

The Avulavirus within the family Paramyxoviridae includes at least 22 different species, and is known to cause different types of infections and even be fatal in multiple avian species. There is limited knowledge of the genetic and biological information of Avulavirus species 2 to 22 in domestic and wild birds and the disease significance of these viruses in birds is not fully determined, although as many as 10 new distinct species have been identified from wild birds and domestic poultry around the world in the last decade. This study aimed to use PCR, virus isolation, and sequencing to genetically and biologically characterize Avian Orthoavulavirus 16 (AOAV-16) in wild birds and domestic poultry collected from different locations in China between 2014 and 2022. Of five isolated AOAV-16 strains (Y1 to Y5), only the Y4 strain had a haemagglutination (HA)-negative result. All of these isolates were low virulent viruses for chickens, except Y3 which was detected simultaneously with avian influenza virus (AIV) of H9N2 subtype. Furthermore, at least four different types of intergenic sequences (IGS) between the HN and L genes junction, and recombination events, as well as interspecific transmission by wild migratory birds, existed within the species AOAV-16. These findings and results of other reported AOAV-16 strains recommend strict control measures to limit contact between wild migratory birds and domestic poultry and imply potential threats to commercial poultry and even public health challenges worldwide. RESEARCH HIGHLIGHTS: First confirmation of AOAV-16 in domestic and wild birds in China. AOAV-16 are low virulent viruses for chickens. Co-circulation/co-infection of AOAV-16 and H9N2 subtype AIV enhanced pathogenicity. Different intergenic sequences and recombination events exist within AOAV-16. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to examine the direct and indirect relations between short-term memory (STM), reading, oral language, and writing at the letter, word, and discourse levels in young, developing writers both cross-sectionally and longitudinally. Method: Participants were 449 English-speaking kindergarten students (52% female) from 41 schools in the U.S. Results: The cross-sectional analysis indicated that STM was directly related to oral language (β = 0.62), letter naming fluency (β = 0.43), word reading (β = 0.54), and reading comprehension (β = 0.42), all of which were statistically significant. Results supported a complete mediation model with STM having an indirect effect on writing via reading and oral language. In the cross-sectional analysis, the total effects of STM on handwriting (β = 0.51), spelling (β = 0.57), and written composition (β = 0.47) were substantial and statistically significant. In the longitudinal analysis, the total effects of Fall STM on Spring writing outcomes, handwriting (β = 0.42), spelling (β = 0.70), and written composition (β = 0.44) were also substantial and statistically significant. Conclusion: Findings confirm that STM is a foundational cognitive skill necessary for early writing; however, they provide a more nuanced understanding by showing that the contribution of STM is indirect through reading and oral language. Writing is complex, requiring interaction among higher-order domain-specific and domain-general components. Along with other recent studies, our findings highlight the need to examine the direct and indirect effects for a more precise understanding of skills that support writing development. [ABSTRACT FROM AUTHOR]

AbstractPurpose: This study evaluates the evolution and focal points of research on death anxiety among cancer patients over the last three decades, utilizing bibliometric analyses.Methods: We analyzed publications related to death anxiety among cancer patients from January 1994 to January 2024 using data from the Web of Science Core Collection. Bibliometric indicators such as the number of publications, leading countries, institutions, and research themes were examined.Results: A total of 2,602 papers from 286 institutions across 97 countries were identified. There has been a significant increase in research interest, particularly between 2014 and 2023, with a peak in 2022. The United States and Harvard University were found to be the most prolific contributors. Major research themes include quality of life, palliative care, mental health, and cancer-specific concerns.Conclusion: The results highlight the rapid development in the field of death anxiety research among cancer patients, with an increase in publications and emerging research themes. However, there is limited international and institutional collaboration. The study underscores the need for enhanced cooperative efforts to advance understanding and research in this area, suggesting directions for future research. [ABSTRACT FROM AUTHOR]

The tissue stiffness of donor kidneys in transplantation may increase due to pathological changes such as glomerulosclerosis and interstitial fibrosis, and those changes associate worse outcomes in kidney transplantation recipients. Ultrasound elastography is a noninvasive imaging examination with the ability to quantitatively reflect tissue stiffness. Aim of this study was to evaluate the prognostic value of ultrasound elastography for adverse kidney outcome in kidney transplantation recipients. Shear wave elastography (SWE) examinations were performed by two independent operators in kidney transplantation recipients. The primary outcome was a composite of kidney graft deterioration, all-cause re-hospitalization, and all-cause mortality. Survival analysis was calculated by Kaplan-Meier curves with the log-rank test and Cox regression analysis. A total of 161 patients (mean age 46 years, 63.4% men) were followed for a median of 20.1 months. 27 patients (16.77%) reached the primary endpoint. The mean and median tissue stiffness at the medulla (hazard ratio: 1.265 and 1.229, respectively), estimated glomerular filtration rate (eGFR), and serum albumin level were associated with the primary outcome in univariate Cox regression. Adding mean or median medulla SWE to a baseline model containing eGFR and albumin significantly improved its discrimination (C-statistics: 0.736 for the baseline, 0.766 and 0.772 for the model added mean and median medulla SWE, respectively). The medullary tissue stiffness of kidney allograft measured by shear wave elastography may provide incremental prognostic value to adverse outcomes in kidney transplantation recipients. Including SWE parameters in kidney transplantation recipients management could be considered to improve risk stratification. [ABSTRACT FROM AUTHOR]

Based on the panel data for 30 provinces in China from 2004 to 2020, this study explores the impact of technological innovation and environmental regulation on agricultural green total factor productivity by using the dynamic spatial Durbin panel model and the spatial panel threshold regression model. The results show that technological innovation significantly contributes to the improvement of AGTFP. Such positive impact is derived from the direct effect of technological innovation within the local province and the spatial spillover effect of technological innovation in neighboring provinces. Additionally, environmental regulation has a significant double-threshold effect on the technological innovation - AGTFP relationship. Within medium-level environmental regulation, the positive impact of technological innovation on AGTFP achieves a leap forward. Therefore, technological innovation serves as a motivator of agricultural green development, and appropriate intensity of environmental regulation is recommended in the endeavor of promoting green total factor productivity by technological innovation. [ABSTRACT FROM AUTHOR]

Oligoasthenozoospermia is becoming a serious problem, but effective prevention or treatment is lacking. Hyperoside, one of the main active ingredients in traditional Chinese medicine, may be effective in the treatment of oligoasthenozoospermia. In this study, we used cyclophosphamide (CTX: 50 mg/kg) to establish a mouse model of Oligoasthenozoospermia to investigate the therapeutic effect of hyperoside (30 mg/kg) on CTX-induced oligoasthenozoospermia. All mice were divided into four groups: blank control group (Control), treatment control group (Hyp), disease group (CTX) and treatment group (CTX + H). Mice body weight, testicular weight, sperm parameters and testicular histology were used to assess the reproductive capacity of mice and to explore the underlying mechanism of hyperoside in the treatment of oligoasthenozoospermia by assessing hormone levels, protein levels of molecules related to hormone synthesis and transcript levels of important genes related to spermatogenesis. Treatment with hyperoside significantly improved sperm density, sperm viability and testicular function compared to untreated oligoasthenozoospermia mice. In mechanism, treatment with hyperoside resulted in significant improvement in pathological changes in spermatogenic tubules, with an increase in testosterone production, and upregulations of Protein Kinase CAMP-Activated Catalytic Subunit Beta (PRKACB), Steroidogenic Acute Regulatory Protein (STAR), and Cytochrome P450 Family 17 Subfamily A Member 1 (CYP17A1) for testosterone production. Hyperoside also promoted the cell cycle of germ cells and up-regulated meiosis and spermatogenesis-related genes, including DNA Meiotic Recombinase 1 (Dmc1), Ataxia telangiectasia mutated (Atm) and RAD21 Cohesin Complex Component (Rad21). In conclusion, hyperoside exerted protective effects on oligoasthenozoospermia mice by regulating testosterone production, meiosis and sperm maturation of germ cells. [ABSTRACT FROM AUTHOR]

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The purpose of the current study was to examine parent racial-coping socialization as a moderator of the relation between racial-ethnic microaggressions and two key outcomes for emerging adults- growth mind-set and psychological well-being. A sample of Black emerging adults (N = 441, Mean age = 18.7 years, 81% female) attending a Minority-Serving Institution (MSI) completed the study. Problem-focused (e.g., parents told me to be aware and double my efforts) and support-focused coping (e.g., parents told me to ask for advice) were independently examined as racial coping socialization. Well-being was a composite score of 6 areas (e.g., personal growth, self-acceptance). Growth mind-set captured the belief that intelligence can be developed with effort. Regression results showed racial-ethnic microaggressions were associated with lower well-being and lower growth mind-set. Problem-focused and support-focused coping independently predicted higher well-being and greater growth mind-set. Racial social support coping buffered the negative association between racial microaggressions and well-being. Implications for the role of parents in the development of emerging adults' resilience will be discussed. [ABSTRACT FROM AUTHOR]

Research Findings: Hierarchical regression analyses were conducted to examine the associations among the family pandemic experience, home activities during the stay-at-home quarantine, and level of parental stress. The results showed that, Chinese parents perceived only significantly higher stress related to children's behavioral and emotional difficulties during the pandemic. Parents' educational level and teacher remote support were significantly associated with the frequency of different home activities for young children. Although family direct exposure of COVID-19 was a critical risk factor predicting parent-perceived stress, parents' education, family income, and teachers' support were important protective factors for parents' stress. Some learning-focused home activities showed an inverse association with parental stress. Practices or Policy: The findings of this study point to the importance of supporting parents to provide quality home-based learning for their young children during the COVID-19 pandemic. Professional support should also focus on the quality of parent-child interaction in addition to the promotion of children's learning experience at home. [ABSTRACT FROM AUTHOR]

Peer assessment is increasingly being used as a pedagogical tool in classrooms. Participating in peer assessment may enhance student learning in both cognitive and non-cognitive aspects. In this study, we focused on non-cognitive aspects by performing a meta-analysis to synthesize the effect of peer assessment on students' non-cognitive learning outcomes. After a systematic search, we included 43 effect sizes from 19 studies, which mostly involved learning strategies and academic mind-sets as non-cognitive outcomes. Using a random effects model, we found that students who had participated in peer assessment showed a 0.289 standard deviation unit improvement in non-cognitive outcomes as compared to students who had not participated in peer assessment. Further, we found that the effect of peer assessment on non-cognitive outcomes was significantly larger when both scores and comments were provided to students or when assessors and assessees were matched at random. Our findings can be used as a basis for further investigation into how best to use peer assessment as a learning tool, especially to promote non-cognitive development. [ABSTRACT FROM AUTHOR]

With online course delivery on the rise, it is essential to understand the preparedness of students attending traditional universities. Prior research has found that some students struggle in online courses, which leads to a quest to better understand the reason why. Studies of self-regulated learning (SRL) in online and blended courses have added to our understanding. However, few studies have used a person-centered approach to study profiles of SRL in fully online courses, and none with a population of students attending a traditional university. This is of importance, especially at a time when traditional universities are increasingly providing online courses. To address the gaps in previous SRL profile research, the current study examined individual differences in SRL profiles of 477 students attending online courses at a traditional university setting, using the Online Self-regulated Learning Questionnaire (OSLQ). Using latent profile analysis, we found four different profiles, with a majority of the students falling in groups representing lower levels of SRL skills. We also explored the possible relationship of experience in online learning, online comfort, age, and gender with the identified self-regulated learning profiles. Relationships were found between the profiles and comfort level as well as with gender. [ABSTRACT FROM AUTHOR]

The role of radiotherapy (RT) in the management of advanced Hodgkin Lymphoma (HL) is inadequately defined in this era of functional imaging with PET scan. SWOG-S0816 treated advanced stage Hodgkin lymphoma patients with ABVD+/- escBEACOPP and no RT. We queried whether RT might have benefited patients in S0816 who would have met the GHSG-HD15 criteria for RT by simulating RT use as per HD15 criteria of PET + residual disease ≥2.5 cm. Receiver-operating-characteristics analyses were performed by varying disease-control rates within radiation fields and size cutoffs for residual disease. Among the 49 PET3+ S0816 patients, RT would have raised the 2-year PFS from 30.6% to 50.2–58.1% using three residual disease cutoffs (1.5, 2.0 and 2.5 cm) and assuming 80 and 90% in-field control rates. Although there may be improvement in PFS as size cutoff point is lowered, consequential toxicities from RT require further definition to assess relative benefits. [ABSTRACT FROM AUTHOR]

In this study, bio-organic fertiliser (BOF) fortified by Bacillus cereus was used as a biocontrol method to reduce tobacco bacterial wilt disease and improve soil quality. The effects of BOF application on the control of tobacco bacterial wilt disease were compared against conventional fertiliser (CF) and improved fertiliser (IF). Further, comparisons of soil physiochemical and microbiological differences were conducted. BOF was the most effective treatment in controlling tobacco bacterial wilt disease, with a control percentage of 31.43% after 95 d of tobacco transplantation. After BOF treatment, the contents of available nitrogen, available phosphorus and organic matter in rhizosphere soils were all significantly higher than in those of the CF and IF treatments, while available potassium content and soil pH were lower. The BOF treatment significantly promoted the growth of cultivable bacterial populations in the soil compared to the other two treatments, with increases in cells of 178.19% compared against the CF treatment soils. The BOF and IF treatments also significantly promoted the diversity of soil bacteria during the rapid-growth stage compared against the CF treatment. Thus these results suggest that BOF treatment can improve the ecological stability of soils and help mitigate tobacco bacterial wilt disease. [ABSTRACT FROM AUTHOR]

The Classroom Assessment Scoring System (CLASS) has been used extensively to measure teacher-student interactions and classroom quality. With a theoretical foundation rooted in the developmental theory of learning, CLASS has three primary domains—Emotional Support, Classroom Organization, and Instructional Support. In this study, we performed a meta-analysis of the factor structure of CLASS using Cheung's two-stage structural equation modeling (TSSEM) approach. After searching the literature, we obtained 26 correlation matrices of the 10 dimensions shared by multiple versions of CLASS. This meta-analysis supports the three-factor model initially proposed by CLASS developers. The finding of this meta-analysis provides important evidence pertinent to the CLASS factor structure and has significant implications regarding the interpretation and use of CLASS scores. [ABSTRACT FROM AUTHOR]

Researchers have been interested in classifying massive open online course (MOOC) students based on their learning behaviors. However, less attention has been paid to the cognitive attributes associated with various learning behaviors. In this study, we propose a conceptual model that links MOOC students' observable learning behaviors to their latent attributes (i.e., individual learning versus interactive learning). Using students' behavior data from a MOOC, we performed a cognitive diagnostic analysis to identify the students' learning profiles and to determine how these profiles related to their course achievement. We found that a large portion of the students performed individual learning whereas only a very small portion of them overtly performed interactive learning. In addition, the students who performed interactive learning were more likely to pass the course with distinction than the students who did not show this attribute. The results of this study have important implications for improving students' learning in MOOCs. Further, the study provides a good demonstration of how to use clickstream process data for psychometric analysis. [ABSTRACT FROM AUTHOR]

In recent years, there has been an increasing use of peer assessment in classrooms and other learning settings. Despite the prevailing view that peer assessment has a positive effect on learning across empirical studies, the results reported are mixed. In this meta-analysis, we synthesised findings based on 134 effect sizes from 58 studies. Compared to students who do not participate in peer assessment, those who participate in peer assessment show a.291 standard deviation unit increase in their performance. Further, we performed a meta-regression analysis to examine the factors that are likely to influence the peer assessment effect. The most critical factor is rater training. When students receive rater training, the effect size of peer assessment is substantially larger than when students do not receive such training. Computer-mediated peer assessment is also associated with greater learning gains than the paper-based peer assessment. A few other variables (such as rating format, rating criteria and frequency of peer assessment) also show noticeable, although not statistically significant, effects. The results of the meta-analysis can be considered by researchers and teachers as a basis for determining how to make effective use of peer assessment as a learning tool. [ABSTRACT FROM AUTHOR]

Phase II data suggest a benefit to autotransplantation for aggressive T-cell non-Hodgkin lymphoma (T-NHL) in first remission; randomized trials have yet to validate this. We performed a retrospective analysis of aggressive T-NHL patients in the intergroup randomized consolidative autotransplant trial (SWOG 9704). Of the 370 enrolled, 40 had T-NHL: 12 were not randomized due to ineligibility (n = 1), choice (n = 2), or progression (n = 9), leaving 13 randomized to control and 15 to autologous stem cell transplantation (ASCT). Two ASCT patients refused transplant and one failed mobilization. The 5-year landmark PFS/OS estimates for ASCT vs. control groups were 40% vs. 38% (p =.56), and 40% vs. 45% (p =.98), respectively. No difference was seen based on IPI, or histologic subtype. Only 1/7 receiving BCNU-based therapy survived vs. 4/5 receiving TBI. Aggressive T-NHL autotransplanted in first remission did not appear to benefit from consolidative ASCT. This and the 30% who dropped out pre-randomization mostly to progression, suggests that improved induction regimens be developed. [ABSTRACT FROM AUTHOR]

A transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which wasin situgenerated from 2-bromopyridine withi-PrMgCl·LiCl. [ABSTRACT FROM AUTHOR]

The potential of anoxic biological arsenite oxidation with nitrate as the sole electron acceptor was tested by using the acclimatized activated sludge which was chronically exposed under arsenite and nitrate coexisted aquatic environment. The activated sludge cultivated in a sequencing batch reactor was fed with arsenite and nitrate as the main substrates over six months. A series of batch experiments were conducted with acclimated sludge. Results showed that no obvious inhibition was observed in the anoxic arsenite oxidation linked to nitrate and nitrite reduction at the concentration of arsenite up to 35 mg AsIII L−1. Moreover, it was found that nitrite was accumulated over the reaction probably due to limited availability of arsenite. The kinetic study further suggested that the maximum specific arsenite oxidation rates (qobs, max) with nitrate and nitrite as the electron acceptors were found to be 0.55 ± 0.10 mg AsIII g−1VSS min−1and 0.40 ± 0.04 mg AsIII g−1VSS min−1, respectively. [ABSTRACT FROM AUTHOR]

Femtosecond laser is ideal tool for micro-machining of hard and brittle materials, such as quartz material. The basis of experiments on femtosecond laser polishing quartz shown that, when other process parameters were the same, the greater the scanning offset distance, the more obvious ravines in polished surface, the more rough bottom surface. Using MATLAB construct a mathematical model to explain the formation mechanism of roughness. Modeling indicated the parameter of femtosecond polishing should maximize the use of smaller laser energy, recycling roughness mathematical model to select the appropriate offset distance. [ABSTRACT FROM PUBLISHER]

Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer. Polymers with targeted ligands are widely used in the field of molecular ultrasound imaging and targeted tumor therapy. In our study, the nanotheranostic agent was fabricated through filling perfluoropropane (C3F8) into poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs), followed by the formation of gold nanoshell on the surface, then conjugated with anti p53 antibody which has high specificity with the p53 protein overexpressing in breast cancer. The average diameter of the gold nanoshelled PLGA NPs carrying anti p53 antibody (p53-PLGA@Au NPs) was 247 ± 108.2 nm. The p53-PLGA@Au NPs had well-defined spherical morphology and hollow interiors observed by electron microscope, and had a good photothermal effect under the irradiation of an 808 nm laser. The results of laser scanning confocal microscope (LSCM) and flow cytometer (FCM) indicated the specific targeting of p53-PLGA@Au NPs conjugating with breast cancer MCF-7 cells overexpressing p53 proteinin vitro. Also the ultrasound imaging experimentsin vitroshowed that p53-PLGA@Au NPs were suitable for ultrasound contrast imaging. In conclusion, the p53-PLGA@Au NPs are demonstrated to be novel targeted UCAs and may have potential applications in the early diagnosis and targeted near-infrared (NIR) photothermal therapy of breast cancer in the future. [ABSTRACT FROM AUTHOR]

The article discusses the leading cause of mortality in patients with HIV in which interim positron emission tomography (PET)-adapted therapy with advanced Hodgkin lymphoma is being studied. It cites that HIV-infected patients manifest an increase of AIDS-defining cancers and non-AIDS-defining cancers prevalent in population.

In recent years, students’ test scores have been used to evaluate teachers’ performance. The assumption underlying this practice is that students’ test performance reflects teachers’ instruction. However, this assumption is generally not empirically tested. In this study, we examine the effect of teachers’ instruction on test performance at the item level using a hierarchical differential item functioning approach. The items are from the U.S. TIMSS 2011 4th-grade math test. Specifically, we tested whether students who had received instruction on a given item performed significantly better on that item compared with students who had not received such instruction when their overall math ability was controlled for, whether with or without controlling for student-level and class-level covariates. This study provides preliminary findings regarding why some items show instructional sensitivity and sheds light on how to develop instructionally sensitive items. Implications and directions for further research are also discussed. [ABSTRACT FROM PUBLISHER]

Drawing on the programme for international student assessment 2009 US data-set, this study examines the relationship between formative assessment and students’ reading achievement using a structural equation modelling approach. We find that formative assessment is positively related to students’ reading achievement directly and indirectly (through teacher–student relationship and attitude towards reading) for all students. The direct relationship between formative assessment and reading achievement is significantly stronger for Black students than for White students, whether or not student socio-economic status (SES), gender and school mean SES are controlled for. The total relationship (the direct plus the indirect relationship) between formative assessment and reading achievement also appears to be stronger for Black students than for White students; however, the difference is not statistically significant whether or not we control for covariates. No significant difference is found between White and Hispanic students in terms of the direct and the total relationship between formative assessment and reading achievement. Using a nationally representative data-set, this study provides empirical evidence that formative assessment is positively related to students’ reading achievement in general. In addition, this study provides preliminary evidence to show the potential of formative assessment to help reduce achievement gaps between Black and White students. The implications and limitations of the study are also discussed. [ABSTRACT FROM PUBLISHER]

Recent advances in diffuse large B-cell lymphomas (DLBCL) have underscored the importance of tumor microenvironment in escaping host anti-tumor responses. One mechanism is loss of major histocompatibility Class II antigens (MHCII) associated with decreased tumor infiltrating T lymphocytes (TIL) and poor survival. Transcription of MHCII is controlled by CIITA which in turn is regulated by histone acetylation. In this study, we hypothesized that HDAC inhibition with belinostat increases MHCII, CIITA expression, TIL and improves patient outcomes. Primary objective was evaluation of toxicity and response. Twenty-two patients were enrolled for the study. Belinostat was well tolerated with mild toxicity. Two partial responses were observed at 5, 13 months after registration for an overall response rate (ORR) (95% CI) of 10.5% (1.3–33.1%), and three patients had stable disease for 4.7, 42.3+, and 68.4 + months with minimum 3-year follow-up. Included correlative studies support the hypothesis and serve as the basis for SWOG S0806 combining vorinostat with R-CHOP. [ABSTRACT FROM AUTHOR]

Given the wide use of peer assessment, especially in higher education, the relative accuracy of peer ratings compared to teacher ratings is a major concern for both educators and researchers. This concern has grown with the increase of peer assessment in digital platforms. In this meta-analysis, using a variance-known hierarchical linear modelling approach, we synthesise findings from studies on peer assessment since 1999 when computer-assisted peer assessment started to proliferate. The estimated average Pearson correlation between peer and teacher ratings is found to be .63, which is moderately strong. This correlation is significantly higher when: (a) the peer assessment is paper-based rather than computer-assisted; (b) the subject area is not medical/clinical; (c) the course is graduate level rather than undergraduate or K-12; (d) individual work instead of group work is assessed; (e) the assessors and assessees are matched at random; (f) the peer assessment is voluntary instead of compulsory; (g) the peer assessment is non-anonymous; (h) peer raters provide both scores and qualitative comments instead of only scores; and (i) peer raters are involved in developing the rating criteria. The findings are expected to inform practitioners regarding peer assessment practices that are more likely to exhibit better agreement with teacher assessment. [ABSTRACT FROM PUBLISHER]

Although optical image registration methods have been successfully developed over the past decades, the registration of optical and synthetic aperture radar (SAR) images is still a challenging problem in remote sensing. Feature-based methods are considered to be more effective for multi-source image registration. However, almost all of these methods rely on the feature extraction algorithms. In this article, a simultaneous segmentation and feature-based registration method based on an iterative level set and scale-invariant feature transform (ILS-SIFT) is proposed. The core idea consists of three aspects: (1) an iterative procedure that combines image segmentation and matching is proposed to avoid registration failure caused by poor feature extraction; (2) a uniform level set segmentation model for optical and SAR images is presented to segment conjugate features; and (3) an improved SIFT algorithm is employed to determine whether the registration was successful. Experimental results have shown the effectiveness and universality of the proposed method. [ABSTRACT FROM AUTHOR]

In this study, we examined relationships between the use of test results and US students’ math, reading, and science performance in the Programme for International Student Assessment (PISA) 2009. Based on a literature review, we hypothesized that the 16 items in the PISA school questionnaire, which are related to the use of test results, can be categorized according to 4 factors. We validated this hypothesized factor structure using a confirmatory factor analysis and then obtained composite scores for each factor. As revealed by a multilevel analysis, when student and school demographic variables were controlled for, using test results to hold schools accountable to authority and the public was significantly positively related to students’ performance across all 3 subjects. No statistically significant relationship, however, was detected between students’ performance and the following uses of test scores: informing parents of their children’s performance, providing information for instructional purposes, and evaluating teachers and principals. [ABSTRACT FROM PUBLISHER]

This study examines how Chinese ESL learners recognize English words while responding to a multiple-choice reading test as compared to Romance-language-speaking ESL learners. Four adult Chinese ESL learners and three adult Romance-language-speaking ESL learners participated in a think-aloud study with the Michigan English Language Assessment Battery (MELAB) reading test. As indicated by the think-aloud verbal reports, the Chinese ESL learners generally had more difficulty with English vocabulary, probably due to the vast difference between the writing system of Chinese and that of English. Rather, they were found to compensate for their deficiencies in vocabulary knowledge by extensively relying on test-taking strategies. The findings of this study are well supported by the cross-linguistic transfer theory and the compensatory nature of reading comprehension. The implications for teaching English vocabulary skills to Chinese ESL learners are also discussed. [ABSTRACT FROM AUTHOR]

Cancer patients frequently present with activated coagulation pathways and thrombocytosis, which are potentially associated with tumor progression and prognosis. However, the prognostic value of abnormal plasma fibrinogen and platelet levels for the treatment of pancreatic cancer is unclear. The purpose of our study was to evaluate the prognostic value of plasma fibrinogen and platelet levels in pancreatic cancer, and to devise a prognostic model to identify the patients with greatest risk for a poor overall survival. One hundred and twenty-five patients diagnosed with pancreatic ductal adenocarcinoma in our hospital between May 2000 and June 2005 were included in this study. The plasma fibrinogen and platelet levels were examined before treatment and analyzed along with patient clinicopathological parameters and overall survival. The foundation of prognostic model was based on the risk factors according to the Cox proportional hazard model. The incidence of hyperfibrinogenemia and thrombocytosis was 24.8% (31/125) and 15.2% (19/125), respectively. The mean fibrinogen concentration differed significantly between the early (I/II) and late (III/IV) stage patients (3.19 ± 0.70 vs. 3.65 ± 0.90 g/l, p = 0.008). Patients with a higher concentration of plasma fibrinogen and platelets had a worse prognosis ( p < 0.05). There also existed a significant correlation between higher fibrinogen/platelet levels and distant organ metastasis ( p < 0.05, respectively). Bivariate correlation analysis showed that plasma fibrinogen levels correlated significantly with platelet levels ( p = 0.000). Multivariate analysis revealed that pretreatment plasma fibrinogen levels ( p = 0.027), tumor stage ( p = 0.026) and distant metastasis ( p = 0.027) were independent prognostic factors. The median survival time for the low-, intermediate-, and high-risk groups was 9.6 months (95% CI 6.2-13.0), 3.8 months (95% CI 2.3-5.3), and 2.3 months (95% CI 0.9-3.7), respectively ( p = 0.000). Pretreatment plasma fibrinogen and platelet levels closely correlated with tumor progression, metastasis and overall survival in pancreatic cancer. The foundation of prognostic model may help us identify the greatest risk populations with pancreatic cancer. [ABSTRACT FROM AUTHOR]

Based on different language systems and educational practices of their respective countries, hypotheses were made regarding how 15-year-old students from Shanghai-China and the US might differ in the 5 reading subskills designated in the Programme for International Student Assessment (PISA) when they have the same overall reading ability (i.e., when their overall reading ability is controlled for). A multilevel analysis was conducted to test the hypotheses using the PISA 2009 reading dataset. When we controlled for students' overall reading ability, individual socioeconomic status (SES), and school mean SES, Shanghai-Chinese students performed significantly better in integrating and interpreting than US students. Further, when we controlled for students' overall reading ability and school mean SES, US students showed significantly higher performance in reading non-continuous texts than Shanghai-Chinese students, whereas US students showed significantly lower performance in reading continuous texts. The results of this study can inform reading instruction and learning in the 2 countries. [ABSTRACT FROM AUTHOR]

Cognitive diagnostic analyses have been advocated as methods that allow an assessment to function as a formative assessment to inform instruction. To use this approach, it is necessary to first identify the skills required for each item in the test, known as a Q-matrix. However, because the construct being tested and the underlying cognitive processes associated with it are usually not fully understood, establishing a Q-matrix, especially for an existing test, is a challenging task. This study reports the process of constructing and validating a Q-matrix for the reading comprehension section of the Michigan English Language Assessment Battery (MELAB). An initial Q-matrix was first generated based on evidence gathered from related literature, students' think-aloud protocols, and expert ratings. This initial Q-matrix was then validated empirically by applying the fusion model to a large MELAB data set. A well-supported Q-matrix was produced for potential future diagnostic applications. [ABSTRACT FROM AUTHOR]

A meta-analysis using Hierarchical Linear Modeling (HLM) was conducted to examine the effects of test accommodations on the test performance of English language learners (ELLs). The results indicated that test accommodations improve ELLs' test performance by about 0.157 standard deviations—a relatively small but statistically significant increase. Once the potential predictors that may have contributed to the variance of the effect sizes across studies had been accounted for, only English proficiency was found to be significant. Further, the results indicated that ELLs with a low level of English proficiency benefited much more from test accommodations than did those with a high level of English proficiency. Little difference was observed in regard to other factors such as students' ethnicity, students' grade level, or the subject for which they were being examined. Although previous studies have suggested that linguistic simplification may be more effective than other methods, results from this meta-analysis offered no support for that suggestion. [ABSTRACT FROM PUBLISHER]

Test accommodations have been proposed to help overcome the unfair challenges faced by English Language Learners (ELLs) due to their relatively low English proficiency. A test accommodation is regarded as effective when it improves the test performance of ELLs. However, this improvement raises the question of whether such accommodations give ELLs an unfair advantage. One criterion used in determining a test accommodation's fairness is that it should only remove the disadvantage that ELLs face in regard to their low language proficiency, without giving ELLs any additional advantages. This criterion is met when the test accommodation does not improve the test performance of the non-ELLs when the same accommodation is applied to them. To determine the fairness and, thus, the validity of test accommodations for ELLs, a meta-analysis using hierarchical linear modeling was conducted to compare the effects of test accommodations on the test performance of ELLs and on that of non-ELLs. The results indicated that test accommodations improved ELLs' test performance by about 0.156 standard deviation units but did not discernibly influence the test performance of non-ELLs. This meta-analysis, therefore, constitutes evidence to support the fairness and validity of providing test accommodations for ELLs. [ABSTRACT FROM AUTHOR]

To evaluate the potential adverse effects caused by pollutants in the surface water sources of drinking water in Zhengzhou, concentrations of 10 elements were measured and their health risks assessed. The results show that only some concentrations of iron, manganese and fluorine are higher than the corresponding environmental quality standards. Risk assessments indicate that risk quotients (all values with carcinogenic effects of arsenic, three values of worst-case of lead and one value of worst-case of fluorine) exceed the limits respectively; one hazard index of fluorine is more than 1; and all 95% of cancer-risk values of arsenic and lead are above 1.0E-6. [ABSTRACT FROM AUTHOR]

CRTH2 is one of the prostaglandin D2 receptors and plays a proinflammatory role in allergic diseases. Gene expression markers in whole blood induced by CRTH2 activation have not previously been reported. Using microarray analyses of 54 675 genes, we revealed modest gene expression changes in human whole blood stimulated in vitro by a selective CRTH2 agonist, DK-PGD2. Five genes were found to exhibit 1.5- to 2.6-fold changes in expression. The expression of Charcot-Leyden crystal protein/galectin-10 ( CLC/Gal-10) in particular was consistently enhanced in human whole blood stimulated by DK-PGD2, as confirmed by quantitative real-time polymerase chain reaction analyses. DK-PGD2-induced increases in blood CLC/Gal-10 mRNA levels were largely attenuated by the CRTH2 antagonist CAY10471.Thus, the DK-PGD2-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents. [ABSTRACT FROM AUTHOR]

Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) have been implicated in promoting solid tumor growth and metastasis via stimulating tumor-associated angiogenesis. Here we show that certain "liquid" tumors such as acute myeloid leukemia not only produce VEGF but also express functional VEGFR, resulting in an autocrine loop for tumor growth and propagation. In addition, the leukemia-derived VEGF can also stimulate the production of growth factors, including interleukin 6 (IL6) and granulocyte-macrophage colony stimulating factor (GM-CSF), by human endothelial cells, which in turn further promotes the growth of leukemia cells (the paracrine loop). A fully human anti-VEGFR2 (or kinase insert domain-containing receptor, KDR) antibody, IMC-2C6, strongly blocks KDR/VEGF interaction and neutralizes VEGF-stimulated activation of KDR in endothelial cells. In a system where leukemia cells are co-cultured with endothelial cells, IMC-2C6 inhibits both the production of IL6 and GM-CSF by endothelial cells and the growth of leukemia cells. Finally, IMC-2C6 effectively blocks VEGF-induced migration of KDR  +  human leukemia cells, and when administered in vivo , significantly prolonged survival of mice inoculated with KDR  +  human leukemia cells. Taken together, our data suggest that anti-KDR antibodies may have broad applications in the treatment of both solid tumors and certain types of leukemia. [ABSTRACT FROM AUTHOR]