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Platelet transfusion refractoriness (PTR) is an intractable issue in hematological patients, which increases bleeding risks and hospitalization costs to a great extent. We reviewed 108 patients with hematological diseases including acute leukemia, myelodysplastic syndrome, aplastic anemia, and others who received allogeneic hematopoietic stem cell transplantation (HSCT) from January 2019 through December 2020. After multivariable logistic regression, we found that splenomegaly (odds ratio [OR] = 26.98, p <.001) and JAK mutation (OR = 17.32, p =.024) were independent risk factors for PTR. During the period of transplantation, patients in the PTR group had a significantly higher platelet transfusion demand, which was reflected in the increased number of platelet transfusions (10.23 ± 6.696 vs. 5.06 ± 1.904, p <.001). After multivariate adjustment, PTR turned out to be independently associated with worse overall survival (hazard ratio = 2.794, 95% confidence interval = 1.083–7.207, p =.034). In conclusion, we found that splenomegaly and JAK gene mutation were independent risk factors for PTR in patients with hematological diseases. A history of PTR prior to allo-HSCT indicates a poor prognosis. What is the context? Platelet transfusion refractoriness is a critical issue, and it greatly increases bleeding risks and hospitalization costs. Patients with hematological diseases tend to develop PTR. PTR results from immune and nonimmune factors and the latter account for 80–90%. At present, there are few studies focused on the inducing factors of PTR, and the specific mechanism is not clear. What is new? In this study, we investigated 108 patients with hematological disorders who received allogeneic HSCT from January 2019 to December 2020. We found that splenomegaly and JAK gene mutation were independent risk factors for PTR in patients with hematological diseases. PTR had a passive effect on the prognosis of patients after HSCT, as indicated by worse OS and a trend toward lower platelets after transplantation. PTR might affect megakaryocyte reconstitution after transplantation. What is the impact? This study provides evidence that hematological patients with splenomegaly should be alert to the occurrence of PTR, which often indicates a worse prognosis of transplantation. Spleen reduction and JAK inhibitors in the treatment of PTR are worth exploring. Abbreviations PLT: platelets; PTR: platelet transfusion refractoriness; HSCT: hematopoietic stem cell transplantation; OR: odds ratio; HR: hazard ratio; CI: confidence interval; IQR: interquartile range; SD: standard deviation; HLA: human leukocyte antigen; HPA: human platelet antigen; OS: overall survival; RFS: relapse free survival; PI: post-transfusion increment; PPR: percentage platelet recovery; CCI: corrected count increment; ICU: intensive care unit; AA: aplastic anemia; MDS: myelodysplastic syndrome; AML: acute myeloid leukemia; ALL: acute lymphocytic leukemia; CML: chronic myeloid leukemia; CMML: chronic myelomonocytic leukemia; MPN: myeloproliferative neoplasm; SI: splenic irradiation; Abs: antibodies; CR: complete remission; DAC: decitabine; GVHD: graft-versus-host disease; BM: bone marrow; PB: peripheral blood [ABSTRACT FROM AUTHOR]

Asphalt and filler interaction plays a key role on the performances of asphalt mastics and mixtures, while the asphalt and filler interaction ability is in turn affected by the material characteristics. In order to analyse the effects of material characteristics on asphalt and filler interaction, two kinds of matrix asphalt binders and three kinds of fillers were used to prepare asphalt mastics with different filler volume fractions. The dynamic shear rheological properties of these asphalt mastics were measured. The evaluation index K–B–G* was calculated subsequently to analyse the effects of material characteristics on the asphalt and filler interaction ability. The results show that filler volume fraction, filler particle size, SiO2 content and asphalt components had various levels of effects on the asphalt and filler interaction ability. Variance analysis was then conducted to rank these influencing factors from high to low as: (1) filler particle size, (2) asphaltene and resins content, (3) filler volume fraction, and (4) SiO2 content. [ABSTRACT FROM AUTHOR]

The preparation and properties of polypropylene fiber (PPF) reinforced lead zirconate titanate (PZT) flexible materials were investigated in this paper. PPF reinforced PZT composites were prepared by hot pressing. The microstructure, mechanical and electrical properties of PPF reinforced PZT composited were tested by Scanning Electron Microscope (SEM) technology, Universal tester, d33 quasi-static tester and LCR tester and were systematically characterized. The results showed that with the increase of PPF volume fraction, the reticular structures in the composites increase, and the bending strength σc and tensile strength σb of the composites increase; meanwhile, the relative dielectric constant εr and dielectric loss tanδ of the composites decreased gradually, but the piezoelectric strain constant d33 of the composite increases first and then decreases with the increase of PPF volume fraction. When the PPF volume fraction is 50%, the composite has superior mechanical properties and comprehensive electrical properties, and is relatively in mechanical electrical equilibrium with σc is 25.402 MPa, σb is 7.049 MPa, εr is 77.216 and d33 is 15 pC N−1. [ABSTRACT FROM AUTHOR]