1. Regulatory effect of isovitexin on MAPK/NF-κB signal in mice with acute ulcerative colitis.
- Author
-
Liu, Ming-Xiu, Li, Ting, Wang, Wei-Guang, Guo, Jing, Wang, Rui-Rui, He, Hong-Ping, Li, Shu-Quan, and Li, Yan-Ping
- Subjects
- *
ULCERATIVE colitis , *EXPERIMENTAL design , *IN vivo studies , *ANIMAL experimentation , *ONE-way analysis of variance , *IMMUNOHISTOCHEMISTRY , *NF-kappa B , *CELLULAR signal transduction , *T-test (Statistics) , *COMPARATIVE studies , *FLAVONES , *DESCRIPTIVE statistics , *RESEARCH funding , *ENZYME-linked immunosorbent assay , *FLUORESCENT antibody technique , *MITOGEN-activated protein kinases , *MOLECULAR structure , *DATA analysis software , *ACUTE diseases , *MICE - Abstract
The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity (p < 0.01). In addition, isovitexin inhibited the expression of MyD88, TLR4 and NF-κB p65 proteins. At the same time, isovitexin can inhibit the activation of MAPK/NF-κB signaling pathway in RAW264.7 cells. In conclusion, isovitexin has a protective effect on UC mice, and its improvement mechanism of UC might be related to MAPK/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF