1. Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer.
- Author
-
Yoshida, Sayumi, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Akasu, Takafumi, Saruta, Masayuki, Okamoto, Masato, Kitamura, Hiroaki, Fujioka, Shuichi, Misawa, Takeyuki, Akiba, Tadashi, Yanagisawa, Hiroyuki, Sugiyama, Haruo, and Koido, Shigeo
- Subjects
ADENOCARCINOMA ,APOPTOSIS ,CANCER patients ,GENE expression ,LIGANDS (Biochemistry) ,PANCREATIC tumors ,T cells - Abstract
The associations of the immunological status of the pancreatic ductal adenocarcinoma (PDA) microenvironment with prognosis were assessed. A high tumor-infiltrating lymphocyte (TIL) density was associated with a better prognosis. Importantly, even with a high density of TILs, the PDA cells with programed cell death-ligand 1 (PD-L1) expression showed a worse prognosis than the patients with negative PD-L1 expression. A significant association between a better prognosis and a tumor microenvironment with a high TIL density/negative PD-L1 expression was observed. Assessments of a combined immunological status in the tumor microenvironment may predict the prognosis of PDA patients following surgical resection. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF