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Background and objective: Although cutaneous warts are extremely common in children effective treatment does not exist. We combined imiquimod with a salicylic acid solution 15% (SA) on areas, with thick keratin, like palms and soles to increase its penetration through the epithelium.Methods: Patients were randomly divided into two groups. The first group was subjected to cryotherapy with liquid nitrogen every two weeks for a maximum of 3 months. The second group was subjected to treatment with imiquimod 5% daily for 6–10 h onto the warts for five consecutive days per week for a maximum of 3 months.Results: Eighty-six children were included, 35 girls and 51 boys, 49 in the cryotherapy group and 37 in the imiquimod and SA group. At the end of the third month no statistically significant difference could be noted between the imiquimod 5% and salicylic acid and cryotherapy groups (p = 0.154). Thirty (81.1%) children treated with imiquimod 5% and salicylic acid were free from their warts in comparison to 33 (67.3%) children treated with cryotherapy.Conclusions: Imiquimod 5% cream as a monotherapy or in combination with SA can be used safely in children with warts and is equally effective and more effective than cryotherapy in plantar warts.Limitations: Our study is not placebo controlled and spontaneous resolution cannot be ruled out. [ABSTRACT FROM AUTHOR]

We compared the skin compatibility of two menstrual pad technologies in a single-center, parallel, randomized, examiner-blinded study involving adult women. This report presents the results of a subset of 10 participants who had a genital infection within 12 months prior to the start of the study. In a blinded fashion, participants were randomized to receive one of the two pads for use over two menstrual periods. Participants' skin erythema was graded 24–48 hours following cessation of menstrual flow and on day 14 of each menstrual cycle. Participants subjectively reported any sensory effects. Vulvar erythema scores for the mons pubis, labia majora, labia minora, perineum, buttocks, left medial thigh, and right medial thigh assessed after both menstrual cycles were not statistically different between groups or between the two different products. A low incidence of itching and burning occurred in both groups without statistical significance; none of the participants experienced a recurrent or new genital infection. These preliminary results show that participants with recent genital infections included in clinical studies do not exhibit greater vulvar erythema or sensory effects than participants without recent genital infection. The study showed that the safety profile of the products tested remained acceptable in women with recent genital infection. [ABSTRACT FROM AUTHOR]

Background : Cutaneous and sensory effects of sanitary pads with a novel “fabric-like” polyethylene film surface (topsheet) were assessed. Methods : Cutaneous erythema and subjective sensory effects of a test pad with fabric-like film topsheet (group size: 53) and a commercial pad with a conventional nonwoven fabric topsheet (group size: 55) were compared in a randomized, examiner-blind, prospective trial lasting two menstrual cycles. Only the assigned pads were used menstrually. An assigned panty liner brand was worn intermenstrually at participant discretion. Primary outcome measures were 1) the frequency and severity of erythema of the vulva, perineum, buttocks, and upper thighs, as visually scored by using a standard scale postmenstrually (16–84 hours after flow cessation) and intermenstrually (days 12–16); 2) sensory irritation frequency as reported on daily diaries; and 3) product preference ratings. Results : The frequency and severity of erythema did not differ between groups except for cycle 2, when a statistically higher mean erythema score (in the barely perceptible range) occurred postmenstrually on the right thigh (commercial pad group) and intermenstrually on the buttocks (test pad group). The frequency of rubbing, itching, or burning sensations declined from about 2% after cycle 1 to less than 1% after cycle 2, with no consistent difference between groups. The test pad was preferred overall, especially for absorbency and soiling protection. Conclusions : The test pad was well tolerated and comparable in skin compatibility to a commercial pad with a history of acceptable use. [ABSTRACT FROM AUTHOR]