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Amplitude-based exercise training has been shown to be effective in the motor performance of individuals with idiopathic Parkinson's disease, with limited research investigating its effects on Parkinson plus syndromes such as olivopontocerebellar atrophy (OPCA). The purpose of this clinical case report is to examine the effects of amplitude-based training exercises on an individual with OPCA. A 68-year-old man with a 14-month history of OPCA presented to physical therapy with bradykinesia, rigidity, and postural instability. The individual participated in 34 intervention sessions. Pre- and post-test measurements were collected for the following outcome measures: Five Times Sit to Stand (FTSTS); Functional Gait Assessment (FGA); Activities-Specific Balance Confidence Scale (ABC-6); 9 Hole Peg Test (9HPT); preferred and maximal gait speed. Improvements reaching Minimum Detectable Change (MDC) or Minimal Clinically Important Difference (MCID) were recorded with a pre (Week 1) and post (Week 20) intervention: FGA score (4-point improvement (MDC95 = 4 points), preferred gait speed (0.09 meters/second improvement (MCID = 0.05 meters/second)), FTSTS (6-second improvement (MDC95 = 2.3 seconds)), and 9HPT on the dominant hand (3-second improvement (MDC95 = 2.6 seconds)). Fluctuations during the plan of care were observed for these measures, and additional outcomes did not demonstrate a worsening of function. In an individual with OPCA, amplitude-based exercise training as a component of the plan of care increased dynamic balance in walking, gait speed, and hand dexterity. However, these results need to be validated on a larger sample of individuals with OPCA through randomized controlled trials. [ABSTRACT FROM AUTHOR]

This research examined growth and co-occurrence of latent developmental patterns of classroom behavior problems among young, economically disadvantaged children. A nationally representative sample (N = 3,827) of children was assessed for overactive and underactive behavior problems through two years of prekindergarten, kindergarten and first grade. Latent growth mixture modeling revealed three distinct subpopulations of change in overactivity and two in underactivity. A parallel-process growth mixture model showed that well-adjusted patterns of overactivity and underactivity co-occurred in the majority of the sample, whereas co-occurrence of marginal overactivity and underactivity existed in approximately 7% of the sample. Results are discussed in light of theory and implications for practice. Impact Statement Young children's classroom behavior develops in different ways and at different rates, but some patterns of development are more common than others. In looking at children's overactive and underactive behavior, we found that most children have fewer behavior problems from preschool through 1st grade, some have relatively moderate overactive problems that show little change over time, and a small proportion have increasingly difficult problems with overactivity and with underactivity. Even though overactivity and underactivity are distinct aspects of classroom behavior, children with increasing patterns of overactive behavior problems were more likely than expected to also show more underactivity in the classroom, and these children may require more support from parents and teachers during the early school years. [ABSTRACT FROM AUTHOR]

Faecal calprotectin is an important biomarker used in the evaluation of inflammatory bowel disease. The aim of this study was to establish the value of faecal calprotectin concentration as a predictor of remission in ulcerative colitis and its correlation with laboratory, endoscopic and clinical findings. The single centre study included 126 adult patients with established diagnosis of ulcerative colitis consecutively visiting our Day clinic from March 2017 to March 2019. We measured serum biomarkers- CRP, haemoglobin, leukocytes and platelets. Faecal calprotectin was determined from stool, and endoscopy was performed with calculation of MAYO endoscopic subscore system (MES 0–1: remission, and MES 2–3: active disease). Clinical assessment was done by using Mayo score for ulcerative colitis (clinical Mayo score <2:remission, >5: active disease).The statistical analysis was performed using an univariate and multivariate model of disease remission prediction using logistic regression. According to univariate analysis the increase of faecal calprotectin concentration by 10 ug/g is associated with an 8% decrease in probability of disease remission (OR 0.9921, p <.05). In the multivariate analysis, faecal calprotectin remained a significant predictor of disease remission (OR 0.9948, 95% CI 0.9914–0.9982, p =.0028), however, with a significant contribution of C-reactive protein (OR 0.8340, 95% CI 0.7085–0.9818, p =.0292). According to our model the cut off value for faecal calprotectin was 154 ug/g. Our results have shown that faecal calprotectin is an independent predictor of remission in UC patients. The results of our study represent real-life data from a single university centre dealing with FC as a prognostic marker in patients with UC. Faecal calprotectin is an independent predictor of remission in UC patients. Recent studies have suggested that calprotectin correlates well with endoscopic activity of inflammation but correlation of faecal calprotectin in a phase of remission hasn't been evaluated yet. We have found that other inflammatory biomarkers do not correlate well with either endoscopic or clinical activity in ulcerative colitis. [ABSTRACT FROM AUTHOR]

Background and objectives: Ulcerative colitis is a chronic recurrent intestinal inflammatory disease, and its recurrence is difficult to predict. In this review, we summarized the objective indicators that can be used to evaluate intestinal inflammation, the purpose is to better predict the clinical recurrence of UC, formulate individualized treatment plan during remission of UC, and improve the level of diagnosis and treatment of UC. Methods: Based on the search results in the PUBMED database, we explored the accuracy and value of these methods in predicting the clinical recurrence of UC from the following three aspects: endoscopic and histological scores, serum biomarkers and fecal biomarkers. Results: Colonoscopy with biopsy is the gold standard for assessing intestinal inflammation, but it is invasive, inconvenient and expensive. At present, there is no highly sensitive and specific endoscopic or histological score to predict the clinical recurrence of UC. Compared with serum biomarkers, fecal biomarkers have higher sensitivity and specificity because they are in direct contact with the intestine and are closer to the site of intestinal inflammation. Fecal calprotectin is currently the most studied and meaningful fecal biomarker. Lactoferrin and S100A12, as novel biomarkers, have no better performance than FC in predicting the recurrence of UC. Conclusions: FC is currently the most promising predictive marker, but it lacks an accurate cut-off value. Combining patient symptoms, incorporating multiple indicators to construct a UC recurrence prediction model, and formulating individualized treatment plans for high recurrence risk patients will be the focus of UC remission management. [ABSTRACT FROM AUTHOR]

Side effects restrict the optimal use of antipsychotics. Little is known about the influence of substance use on side effects. The aim of this study was to compare antipsychotic side effects in patients with psychosis with and without substance use, while also taking medication history and diagnosis into consideration. All patients (n = 226, mean age 34, females 33%) diagnosed with schizophrenia spectrum disorders (SSD; F20–F29) or other psychosis (F30-F32; F10-F19), were treated with olanzapine, quetiapine, risperidone or ziprasidone, and were assessed at baseline, 4-weeks, 14-weeks, and 27-weeks. The UKU-Side Effects Self-Rating Scale version was used to evaluate the side effect profiles, and the information on substance use was based on the Clinician Drug Use Scale. At baseline, 30% of the patients used substances, 54% were diagnosed with SSD, and 47% were antipsychotic naïve. The occurrence of side effects in total was not different in patients with substance use compared to without after 4-weeks of treatment, nor in the follow-up period. At 4-weeks there were some group differences in relation to substance use, diagnosis, and medication history for single side effects. Patients with substance use showed more increased dream activity, less reduced salivation, and more gynecomastia. Patients with SSD showed less neurological side effects, orgasm dysfunction, and tension/inner unrest. The medication naïve patients showed increased hypokinesia/akinesia. Substance use alone does not influence the general magnitude of side effects of antipsychotic medication and does not indicate a different prescription practice in patients with psychosis and substance use. [ABSTRACT FROM AUTHOR]

Sedentary living is a serious global public health problem that is associated with numerous preventable diseases. Schools are in a position to be the most cost-effective public resource to combat inactivity. In schools physical educators are positioned to be the strongest advocates of a healthy, active lifestyle. To effectively promote physical activity on school campuses and to encourage it in communities beyond the school day, physical educators will need to develop skills that are not typically stressed in undergraduate physical education teacher education (PETE) programs. As a result, both undergraduate PETE and in-service staff-development programs will need to be revised if schools are to play a major role in physical activity promotion. [ABSTRACT FROM AUTHOR]

Adolescent physical inactivity has risen to an alarming rate. Several theoretical frameworks (models) have been proposed and tested in school-based interventions. The results are mixed, indicating a similar weakness as that observed in community-based physical activity interventions (Baranowski, Lin, Wetter, Resnicow, & Hearn, 1997). The theoretical models were decontextualized, thus are unable to address issues central to adolescents' physical activity behavior. In this article, we propose using a theoretical model derived from school-based research on learning behavior change. We review related research on adolescents' physical activity to demonstrate the relevance of using the model to study the dynamic impact of personal, school curriculum, and community variables on adolescent physical activity. We also translate the conceptual model into empirically testable cross-sectional and longitudinal latent growth models and propose concrete steps researchers can take to design empirical studies to examine them. We believe that research studies guided by the proposed conceptual and empirical models will provide useful data for us to better understand the mechanisms of adolescent physical activity motivation and behavior change. [ABSTRACT FROM AUTHOR]

Physical inactivity is increasingly recognized as a public health problem due to the increased risks for chronic diseases and disabling physical conditions that limit movement and mobility in adults. During the past 15 years, public health activities have focused on understanding factors that influence physical activity behaviors and in identifying ways to minimize physical inactivity. Efforts have focused on conducting physical activity surveillance systems, evaluating policies related to active lifestyles, and sponsoring research studies to understand how coordinated multidisciplinary approaches can reduce physical inactivity in communities. Population demographics associated with an aging society provide opportunities for federal and local agencies and organizations to identify effective ways for adults to remain physically active on a regular basis. [ABSTRACT FROM AUTHOR]

Examines the problem of physical inactivity from the perspective of exercise adherence. Causal determinants of physical activity; Importance of restructuring past activity history to interpret past and present determinants; Change of attitudes, beliefs and expectancies, values and intentions.

Objective: To develop a questionnaire for the differential diagnosis of detrusor underactivity (DUA) and bladder outlet obstruction (BOO) without performing invasive pressure flow studies.Study Design and Methods: Symptoms of men with DUA were analyzed and compared with those of men with BOO using eight questions from the developing questionnaire. Patients with DUA have a bladder contractility index (PdetQmax+5xQmax) less than 100, whereas those with BOO have a BOO index (PdetQmax-2xQmax) greater than 40 in urodynamic studies (UDS). Men with detrusor overactivity in UDS and neurogenic issues were excluded from the analysis. One urologist reviewed patients' medical records, and responded to eight questions without using information from UDS. Scores in the developing questionnaire were then compared to make a differential diagnosis between DUA and BOO.Results: Overall, 318 men who underwent UDS were included. Symptoms were compared in patients diagnosed with DUA without BOO (n = 165) and BOO without DUA (n = 153). Questions 1, 2, 4, 5, 6, and 7 were significantly different between groups. The sensitivity and specificity of the questionnaire were 95.8% and 95.4%, respectively, for predicting DUA in patients with scores greater than 45 points (cutoff value).Conclusions: Men with DUA and BOO may be distinguished using a developing questionnaire without invasive evaluation. Men with scores greater than 45 points would be expected to have DUA but not BOO. [ABSTRACT FROM AUTHOR]

Despite the growing interest in sedentarism, there is no available information on the profile of patients with COPD according to sedentary behaviour (SB) and with a detailed analysis of minute-by-minute bouts. Hence, the aims of this study were to quantify the time spent in SB, light activities and moderate-to-vigorous physical activities (MVPA) and to verify the relationship of MVPA and SB in individuals with COPD, as well as to identify the profile of those physically (in)active and (non)-sedentary. A cross-sectional study in which physical activity in daily life was objectively assessed through the use of SenseWear Pro 2 Armband (BodyMedia) during 2 consecutive weekdays, 12 h/day. Analysis was performed minute-by-minute for each day of each patient. MVPA comprised time spent >3 metabolic equivalents (MET), whereas light activities corresponded to time spent between 1.5 and 3 MET and SB to time spent <1.5 MET. A total of 137 subjects with COPD (66 ± 8years; FEV1 46 [31-57] %pred; BMI 26 [22-30] kg/m2) were analysed. Time spent in MVPA and SB presented strong negative correlation (r = −0.72, P < 0.001). Minute-by-minute analysis showed that patients with COPD spend most of their time in SB. SB accounted for 40% of all bouts >1 minute, whereas only 14% these bouts concern MVPA. Patients combining two positive characteristics (physically active and non-sedentary) have better clinical profile than others. In conclusion, SB is negatively correlated with MVPA in patients with COPD. Furthermore, patients classified as physically active (i.e., those who reach MVPA recommendations) in combination with a non-sedentary lifestyle present markedly better clinical conditions. [ABSTRACT FROM AUTHOR]

Chronic obstructive pulmonary disease (COPD) has systemic consequences that lead to reduced physical activity in daily life (PADL). Little is known about PADL and its associations in individuals with COPD on home-based long-term oxygen therapy (LTOT). The objective of the study was to determine whether there is an association between severe physical inactivity and pulmonary function, fatigue, dyspnea, functional status and exercise capacity in individuals with COPD on home-based LTOT using electric oxygen concentrators and to investigate which of these variables could influence inactivity in these individuals. The population sample included 39 individuals with COPD who were on LTOT (69 ± 8 years, FEV1: 32 ± 14% predicted). They were assessed in terms of PADL (number of steps/day), fatigue (Fatigue Severity Scale - FSS), dyspnea (Medical Research Council - MRC scale), functional status (London Chest ADL scale [LCADL] and Timed Up and Go [TUG] test) and functional exercise capacity (Six-Minute Step test [6MST] and Sit-to-Stand test [STST]). PADL was markedly low (1444 ± 1203 steps/day) and associated with daily duration of LTOT (r = -0.50), fatigue (r = -0.36), LCADL (r = -0.41), 6MST (r = 0.48), and STST (r = 0.53) (p <.05 for all). Multiple linear regression revealed that daily duration of LTOT and STST explained 39% of the variability of PADL. Longer daily duration of LTOT, fatigue, worse functional status and exercise capacity were all associated with physical inactivity in individuals with COPD on LTOT, whereas daily duration of LTOT and the STST were determinants of reduced physical activity. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study is to investigate the effects of transcranial direct current stimulation (tDCS) combined with cueing gait training (CGT) on functional mobility in patients with Parkinson´s disease (PD).Methods: A pilot double-blind controlled, randomized clinical trial was conducted with 22 patients with PD assigned to the experimental (anodal tDCS plus CGT) and control group (sham tDCS plus CGT). The primary outcome (functional mobility) was assessed by 10-m walk test, cadence, stride length, and Timed Up and Go test. Motor impairment, bradykinesia, balance, and quality of life were analyzed as secondary outcomes. Minimal clinically important differences (MCIDs) were observed when assessing outcome data.Results: Both groups demonstrated similar gains in all outcome measures, except for the stride length. The number of participants who showed MCID was similar between groups.Conclusion: The CGT provided many benefits to functional mobility, motor impairment, bradykinesia, balance, and quality of life. However, these effect magnitudes were not influenced by stimulation, but tDCS seems to prolong the effects of cueing therapy on functional mobility. [ABSTRACT FROM AUTHOR]

Background. Spirometry patterns suggesting restrictive and obstructive pulmonary dysfunction have been reported in Parkinson’s disease (PD). However, the patterns’ precise relation to PD pathophysiology remains unclear.Purpose/Aim. To assess ON- versus OFF-state pulmonary function, the quality of its spirometric evaluation, and the quality of longitudinal spirometric findings in a large sample of PD patients with motor fluctuations.Methods. During a placebo-controlled trial of an inhaled levodopa formulation, CVT-301, in PD patients with ≥2 h/d of OFF time, spirometry was performed by American Thoracic Society (ATS) guidelines at screening and throughout the 4-week treatment period.Results. Among 86 patients, mean motor impairment during an OFF state at screening was moderately severe. However, mean spirometry results at screening were within normal ranges, and in a mixed model for repeated measures (MMRM), the results at screening were not dependent on motor state (ON vs. OFF). In the placebo group (n= 43), 76% of ON-state and 81% of OFF-state examinations throughout the study met ATS quality metrics, and in an MMRM analysis, mean findings at these patients’ arrivals for treatment-period visits showed no significant 4-week change. Across all 86 patients, flow-volume curves prior to any study-drug administration showed only a 3% incidence of “sawtooth” morphology.Conclusions. In PD patients with motor fluctuations, longitudinal spirometry of acceptable quality was generally obtained. Although mean findings were normal, about a quarter of spirograms did not meet ATS quality criteria. Spirogram morphology may be less indicative of various forms of respiratory dysfunction than has previously been reported in PD. [ABSTRACT FROM PUBLISHER]

Objective: To explore neurons with β oscillatory activity in the subthalamic nucleus (STN) in relation to parkinsonian motor signs.Methods: We studied 27 patients with Parkinson's disease (PD) who underwent electrode implantation for STN deep brain stimulation. Thirteen patients were classified as akinetic-rigid (AR) type and 14 patients were classified as mixed type. Microelectrode recording was performed in the STN and the electromyogram (EMG) was simultaneously recorded. Single-unit and spectral analyses were performed. Coherence analysis was used to explore the relationship between β oscillatory activity and EMG activity. Unpairedt-test and chi-square were used to compare the differences between the two PD types.Results: Of 130 neurons identified in the AR type, 43.8% were β oscillatory neurons (mean: 21.3 ± 6.87 Hz, βFB) and 0.8% were tremor frequency oscillatory neurons (4–6 Hz, TFB). Of 102 neurons identified in the mixed type, 19.6% were β oscillatory neurons and 26.5% were TFB oscillatory neurons. There was a significant difference in proportion of neurons with βFB and TFB oscillations between the two PD groups. Additionally, 12% of the βFB oscillatory neurons were coherent with limb EMG of the AR type, but there was no coherence in the mixed type. Most oscillatory neurons were localized in the dorsal portion of the STN.Conclusion: The STN βFB oscillatory neurons correlate with parkinsonian rigidity-bradykinesia. The high proportion of βFB oscillatory neurons found in the AR type of PD is indirect evidence for their importance in generating motor impairment. [ABSTRACT FROM AUTHOR]

Parkinson’s disease currently affects millions of people worldwide and is steadily increasing. Many symptoms are associated with this disease, including rest tremor, bradykinesia, stiffness or rigidity of the extremities and postural instability. No cure is currently available for Parkinson’s disease patients; instead most medications are for treatment of symptoms. This treatment depends on the quantification of these symptoms such as hand tremor. This work proposes a new system for mobile phone applications. The system is based on measuring the acceleration from the Parkinson’s disease patient’s hand using a mobile cell phone accelerometer. Recordings from 21 Parkinson’s disease patients and 21 healthy subjects were used. These recordings were analysed using a two level wavelet packet analysis and features were extracted forming a feature vector of 12 elements. The features extracted from the 42 subjects were classified using a neural networks classifier. The results obtained showed an accuracy of 95% and a Kappa coefficient of 90%. These results indicate that a cell phone accelerometer can accurately detect and record rest tremor in Parkinson’s disease patients. [ABSTRACT FROM PUBLISHER]

Background/Objectives: In most right-handed people, the left hemisphere is dominant for programming the temporal and spatial “how” (praxis) aspects of purposeful skilled movements, and the right hemisphere is dominant for control of the intentional “when” aspects of actions that mediate initiation, persistence, termination, and inhibition. Since the interhemispheric axons of the corpus callosum are especially susceptible to shearing from torsional forces during traumatic brain injury (TBI), the goal of this study was to learn whether participants with a history of severe traumatic brain injury demonstrate three types of cognitive–motor impairments that may result from callosal injury: ideomotor apraxia of the left hand, limb kinetic apraxia of the left hand, and hypokinesia of the right hand in response to left hemispatial stimuli.Method: Nine participants with severe TBI and nine healthy control participants were studied for the presence of ideomotor apraxia, limb kinetic apraxia, and hypokinesia.Results: When compared to the control participants, the participants with TBI revealed ideomotor apraxia and limb kinetic apraxia of the left hand and hypokinesia in response to left-sided visual stimuli when tested with the right hand.Conclusions: TBI appears to cause unilateral disorders of cognitive–motor functions. Future research is needed to understand how these cognitive–motor disorders are related to interhemispheric disconnection most likely induced by injury to the corpus callosum. [ABSTRACT FROM PUBLISHER]

Background: Motor symptoms in Parkinson's disease (PD) are typically asymmetrical. Early stage of PD is characterised with a predominantly unilateral appearance of tremor, rigidity and bradykinesia, with or without axial involvement. Also, studies have demonstrated gait asymmetry in de novo drug naïve PD patients. Aim of this study was to investigate gait pattern, gait symmetry and gait variability in early phases of PD. Methods: The gait was measured in 40 de novo, drug naïve PD patients and 43 healthy control subjects (HC) while performing a simple walking task. Calculated parameters were cycle time (CT), stride length (SL) and swing time (ST), and their coefficients of variation (CV). Results: Considering gait parameters, PD patients and HC differed in terms of all parameters, except for the CV of CT. Analysis of gait symmetry, comparison between the gait patterns of the left and the right leg in PD patients revealed no difference for any of the assessed parameters. The majority of the gait parameters did not differ between left and right legs of HC. Conclusions: It can be concluded that even gait was already altered in de novo drug naive PD patients, gait symmetry remained preserved. The SL was the most prominent parameter of altered gait in initial stages of PD patients, while the ST heralded postural asymmetry. [ABSTRACT FROM AUTHOR]

Context. Flufenoxuron (Cascade™) is a new benzoylurea insecticide. We describe a case of human poisoning with previously unreported cardiac complications and review other case reports in the literature. Case details. A 54-year-old stuporous man who had ingested a flufenoxuron-containing insecticide presented to the emergency department with severely unstable vital signs and lactic acidosis which continued to worsen over time. He was treated with gastric lavage and infusion of sodium bicarbonate, crystalloid, and dopamine. The patient was initially unresponsive, but recovered from shock after norepinephrine treatment. While electrocardiography showed no abnormal findings, cardiac enzymes remained elevated for several days. Initial echocardiography showed global left ventricular hypokinesia and a left ventricular ejection fraction of 40%, but echocardiography after 45 h showed normal results. On the sixth day, he was discharged after rejecting medical advice for further evaluation. Discussion. Severe lactic acidosis, shock, elevation of cardiac enzymes, and global left ventricular hypokinesia can occur in human poisoning with flufenoxuron-containing insecticide, and norepinephrine is preferable for the management of shock. [ABSTRACT FROM AUTHOR]

There is growing evidence that speed-based exercise training benefits people with Parkinson's disease (PD). The present study investigates the effects of a single session of volitional, high-speed cycling intervals on a battery of timed functional tests selected for their relevance to the symptom of bradykinesia. Ten subjects with PD (Hoehn-Yahr stage ≤ 3.0) participated in a familiarization session and three test sessions. Functional testing occurred before and after 30 minute sessions in which subjects performed no exercise (NO), pedaled at their preferred cadence (PC), or performed 20, 15-second intervals of high-speed low-resistance cycling (HS-LR). In addition to testing the exercise effects in a within-subjects design, we provide test-retest reliability data, minimal detectable change scores, and correlations among the selected functional tests. Despite the relatively low dose of speed-based exercise, HS-LR elicited significant ( p < 0.05) improvements in the four square step test and 10 m walk test. Excepting reaction times, there was high reliability and adequate sensitivity to detect moderate and small differences. Strong correlations among tests of mobility inform the future selection of measures in the experimental design. In addition to what is known about continuous exercise sessions involving high-speed exercise, the present results suggest that brief intervals of HS-LR bicycling are promising and should be examined in a longer duration exercise program. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the effect of NeuroField pulsed EMF stimulation on Parkinson's Disease (PD) symptoms. Pretreatment, posttreatment, and follow-up QEEG was analyzed along with patient symptom ratings of PD symptoms. The results show significant differences in pre- versus post- versus follow-up QEEG. PD patient symptom ratings were significantly reduced by posttreatment and remained reduced on 30- and 180-day follow-up. NeuroField appears to have potential in reducing PD symptoms. [ABSTRACT FROM PUBLISHER]

Suspiciousness is a common feature of schizophrenia. However, suspicious thoughts are also commonly experienced by the general population. This study aimed to examine the underlying neural mechanism of suspicious thoughts in individuals with and without schizotypal personality disorder (SPD)-proneness, using an event-related potential (ERP) paradigm. Electroencephalography (EEG) was recorded when the “feeling of being seen through” was evoked in the participants. The findings showed a prominent positive deflection of the difference wave within the time window 250–400 ms after stimuli presentation in both SPD-prone and non-SPD-prone groups. Furthermore, the P3 amplitude was significantly reduced in the SPD-prone group compared to the non-SPD-prone group. The current density analysis also indicated hypoactivity in both frontal and temporal regions in the SPD-prone group, suggesting that the frontotemporal cortical network may play a role in the onset of suspicious thoughts. The P3 of difference wave was inversely correlated with the cognitive-perception factor and the suspiciousness/paranoid ideation trait, which provided preliminary electrophysiological evidence for the association of suspiciousness with SPD features. [ABSTRACT FROM AUTHOR]

Patients without sensory neglect might demonstrate a spatial deviation when drawing. To better understand the mechanism of this deviation, we examined a 61-year-old woman with probable posterior cortical atrophy (PCA) who on imaging showed right hemisphere atrophy and dysfunction. When drawing a clock she correctly made a circle, but when writing the numbers deviated to the left. A blindfolded midsagittal plane pointing test revealed that her leftward deviation was action-intentional rather than perceptual-attentional. This action-intentional deviation was made manifest by altering visual feedback such as having her focus her attention on the clock numbers [ABSTRACT FROM AUTHOR]

The article presents a study regarding the link between the accessible outcomes in physical activity and motivational orientations. It mentions the relevance of motivation in eradicating health-related problems such as obesity and diabetes mellitus, due to physical inactivity. It notes the methodologies as well as the tools used for the study. Moreover, the analyses of the research is also provided.

Deciding about hormone therapy (HT) use is particularly complex for women with mobility impairments. While HT controls menopausal symptoms, the potential increased risk of blood clots resulting from physical inactivity can contraindicate HT use. These women, therefore, may benefit from interventions to help them tailor standard information about HT. We randomly assigned women to receive either a tailored decision support intervention or standard menopausal information. Both groups (n = 176) significantly decreased their decisional conflict and uncertainty and increased knowledge after receiving the treatment materials. We interpret the findings in the context of limited medical information about HT for women with disabilities. [ABSTRACT FROM AUTHOR]

Existing studies revealed that bipolar patients show an altered identification of emotional stimuli (e.g. facial expressions), however, so far modifications in early emotional processes and the regulation of emotions are less clear. In response to emotional stimuli bipolar patients show a dysfunction in a ventral-limbic brain network including the amygdala, insula, striatum, subgenual cingulate cortex, ventrolateral prefrontal cortex and orbitofrontal cortex. In most studies, a relative hypoactivity of dorsal brain structures, including the dorsolateral prefrontal cortex, the dorsal anterior cingulate and the posterior cingulate cortex, has been reported in bipolar patients. This imbalance between the two networks has been proposed to underlie deficient emotion regulation in bipolar disorder. [ABSTRACT FROM AUTHOR]

The article discusses the significance of the glycemic index (GI) to human physiology. According to the author, the rising prevalence of overconsumption in inactivity has led to a continued interest in diet and lifestyle modifications. One relevant approach is GI which is a physiological classification of the available carbohydrate content in foods. The link of dietary glycemic index with various diseases like diabetes and heart disease is discussed.

An understanding of the motives underlying sedentary leisure behavior may guide interventions to decrease these behaviors. The purpose of this study was to apply the theory of planned behavior (TPB) to understand the motives underlying four common sedentary leisure activities: television viewing, computer use, reading/music, and socializing. A cross-sectional community sample of 206 adults and 174 undergraduate students completed measures of the TPB of these four leisure behaviors and self-reported behavior. Results using ordinary least squares regression provided evidence that sedentary behaviors may be intentional and planned with a primary attitude base but not related to perceived behavioral control. The findings provide information about sedentary behavior motivation and support the validity of the TPB for the prediction of these behaviors. [ABSTRACT FROM AUTHOR]

The exercise psychology literature is replete with assertions that 'exercise makes people feel better'. However, this appears to be inconsistent with the high prevalence of physical inactivity and drop-out rates. Recent empirical findings, based on a new methodological platform, have demonstrated that the exercise-affect relationship is complex, exhibiting both a dose-response pattern and substantial inter-individual variability. The Dual-Mode Theory was developed to (a) bridge mind-focused and body-focused approaches for explaining the exercise-affect relationship, (b) provide a fit to extant data by accounting for patterns of dose-response and inter-individual variability, and (c) be consistent with information from exercise physiology and emerging evidence on the neural basis of affect. Investigations based on the Dual-Mode Theory could inform the ongoing debate on the role of somatic influences in generating affective responses and guide interventions designed to improve the affective responses of exercisers. A selective review of phenomenological accounts that served as the philosophical basis of the theory supports the thesis that affect has a dual basis, being driven by cognition in many circumstances but by direct somatic cues when homeostasis is challenged. [ABSTRACT FROM AUTHOR]

Background: Physical inactivity leads to higher morbidity and mortality from chronic non-communicable diseases (NCDs) such as stroke and heart disease. In high income countries, studies have measured the population level of physical activity, but comparable data are lacking from most low and middle-income countries. Objective: To assess the level of physical inactivity and its associated factors in selected rural sites in five Asian countries. Methods: The multi-site cross-sectional study was conducted in nine rural Health and Demographic Surveillance System (HDSS) sites within the INDEPTH Network in Bangladesh, India, Indonesia, Thailand, and Vietnam. Using the methodology from the WHO STEPwise approach to Surveillance (STEPS), about 2,000 men and women aged 25-64 years were selected randomly from each HDSS sampling frame. Physical activity at work and during leisure time, and on travel to and from places, was measured using the Global Physical Activity Questionnaire version 2 (GPAQ2). The total activity was calculated as the sum of the time spent in each domain of activities in metabolic equivalent-minutes per week, and was used to determine the level of physical activity. Multivariable logistic regression was used to assess demographic factors associated with a low level of physical activity. Results: The prevalence of physical inactivity ranged from 13% in Chililab HDSS in Vietnam to 58% in Filabavi HDSS in Vietnam. The majority of men were physically active, except in the two sites in Vietnam. Most of the respondents walked or cycled for at least 10 minutes to get from place to place, with some exceptions in the HDSSs in Indonesia and Thailand. The majority of respondents, both men and women, were inactive during their leisure time. Women, older age, and high level of education were significantly associated with physical inactivity. Conclusion: This study showed that over 1/4 men and 1/3 women in Asian HDSSs within the INDEPTH Network are physically inactive. The wide fluctuations between the two HDSS in Vietnam offer an opportunity to explore further urbanisation and environmental impacts on physical activity. Considering the importance of physical activity in improving health and preventing chronic NCDs, efforts need to be made to promote physical activity particularly among women, older people, and high education groups in these settings. [ABSTRACT FROM AUTHOR]

This paper explores parental concern about children's activity levels and whether Parents who are concerned about their child's activity provide a supportive environment. A sample of 615 parents of 5-6-year-old children and 947 parents of 10-12-year-old children completed a questionnaire. Just over 50% of parents reported they were concerned their child was not getting enough activity. Children of concerned parents were less active than those whose parents were not concerned. These findings suggest that parents who are concerned about their child's physical activity levels provided a less supportive environment for physical activity than parents who are not concerned. The challenge for public health will be to harness parental concerns and translate them into action. [ABSTRACT FROM AUTHOR]

Parkinson's disease is a common motor disorder that not only leads to motor symptoms but also autonomic dysregulation, mental changes, sensory disturbances, and sleep disorders such as increased daytime sleepiness and sleep fragmentation. The aim of this study was to find out how the daytime and night-time motor activity levels in individuals without motor disorders differ from patients with Parkinson's disease. Daytime and night-time motor activity levels in 17 PD patients and 69 controls were measured for three consecutive days and nights via actigraphy, a method of continuous long-term assessment of activity levels. A ratio between night-time and daytime motor activity was calculated. PD patients had a 1.5-2-fold lower daytime motor activity but also showed 1.5-2-fold higher motor activity at night time. Older controls showed a lower daytime but similar night-time motor activity when compared to younger controls. A ratio of night-time to daytime motor activity could clearly distinguish controls and patients. The possibility to distinguish patients and controls by the ratio of night-time to daytime motor activity is worth further investigation. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the associations between smoking, physical inactivity, obesity, and asthma severity among US adults. The magnitude of these associations was very strong. For example, those who visited an emergency room in the past year were 60% more likely than those who did not to smoke; those who used an inhaler ≥15 times in the past month (versus those who did not use an inhaler) were 90% more likely to be physically inactive; and those who had asthma symptoms all the time in the past 30 days (versus those with no symptoms) were 80% more likely to be obese. [ABSTRACT FROM AUTHOR]

Objective. We assessed whether antipsychotic drugs represent a risk factor for venous thromboembolism by comparing the prevalence of antipsychotic drugs use in a population of patients with venous thromboembolism versus a group of individuals treated for hypertension. Methods. We identified 266 patients (141 women) diagnosed as having venous thromboembolism at the average age of 43.1±11 years who had been hospitalized in the University Hospital in Hradec Králové from 1 January 1996 to 31 December 2004. Two hundred and seventy-four patients (140 women) with arterial hypertension, with an average age of 48.3±8.8 years, represented the control population. Results. Use of antipsychotic drugs was moderately more frequent in the group of patients with venous thromboembolism as compared with the control group subjects (4.89 vs. 1.82%; odds ratio 2.76; 95% confidence interval=1.01-7.55). Discussion. We discuss the possible mechanisms of venous thromboembolism induced by antipsychotic agents - hypoactivity, blood status, obesity, abnormal coagulation, autoimmune mechanisms, and hyperhomocysteinemia. Conclusion. Our results indicate the possibility of an increased risk for venous thromboembolism in patients using antipsychotic drugs. It is necessary to seriously consider this possible adverse effect owing to its potentially fatal consequences. [ABSTRACT FROM AUTHOR]

This paper examines the use of the Internet as experienced by people with significant mobility/physical impairments who are accustomed to using computers. The study is based on interviews and focuses on computer usage in everyday action and interaction. In many cases, the possibilities that the computer and Internet offer have meant not only important improvements in quality of life, but first-time occurrences of great personal significance. The analysis is phenomenographic, resulting in main categories and subcategories, illustrated primarily through direct quotations. The three main categories are independence, communication, and learning. [ABSTRACT FROM AUTHOR]

Health campaigns have focused on lifestyle decisions such as physical inactivity, diet and smoking to minimise health risks. The links between health, environmental sustainability and consumer food choices have less prominence. Reported here are Australian consumer perceptions of environmental health issues related to the food system. Interviews with 26 participants explored the environmental implications of food choices. Concerns included conflicting information, related health risks, and the blaming of individuals for 'poor' choices. Participants recognised that focussing on the individual overlooked the structural context of food production. They requested information about food production processes to assist decision-making and identified the need for an influential body to advocate for their interests in food production decisions. The results indicate a need for government, industry and consumer collaboration to develop and implement practical communication strategies about food production for communities. [ABSTRACT FROM AUTHOR]

The hypothalamus pituitary adrenal (HPA)- axis is one of the major output systems of the neuroendocrine stress response. Its major end products, glucocorticoids (GCs), have a plethora of effects throughout the organism, most of which are believed to be protective against disturbances of homeostasis. However, negative effects have also been described under specific conditions of hyper- or hypo(re)activity of the HPA axis. Both beneficial and adverse effects of GCs ultimately depend on the target tissue sensitivity to these steroids. Recent findings suggest that GC sensitivity (a) may vary between different target tissues in the same organism, (b) shows large individual differences and (c) can be acutely changed in times of acute stress. In the present review, data are summarized which show differences in GC sensitivities in patients suffering from diverse somatic and psychiatric diseases, as well as chronically stressed individuals. Furthermore, studies are presented that show a rapid modulation of GC sensitivity in response to exercise or psychosocial stress in healthy adults. The response pattern of acute GC sensitivity modulation seems to be influenced by age and sex hormone status of the individual. While the GC signalling cascade may be subject to modulation at several levels, the pathway for acute modulation of GC sensitivity remains to be elucidated. [ABSTRACT FROM AUTHOR]

Physical inactivity is a cardiovascular risk factor that has a higher prevalence among overweight adults. The purpose of this study was to assess the prevalence of not participating in Leisure Time Physical Activity (LPTA) and the relationship to body weight class among older U.S. adults. A nationally representative cross-sectional survey with an in-person interview and medical examination was used. Between 1988 and 1994, 6569 adults 60 years of age or older responded to the household adult and family questionnaires as part of the National Health and Nutrition Examination Survey III. Mexican Americans and non-Hispanic blacks were oversampled to produce reliable estimates for these groups. Overall, 39% of older U.S. adults fall in the overweight range and 23.3% are obese. Obese older adults were more likely than their overweight and healthy weight counterparts to report participating in no LTPA The prevalence of adults reporting no leisure time physical activity (LPTA) is lowest among non-Hispanic whites compared to non-Hispanic blacks and Mexican-Americans in each body mass index category. Future interventions should address strategies to promote an increase in leisure time physical activity among older adults, especially among underserved populations, and help them to prevent weight gain. [ABSTRACT FROM AUTHOR]

Argues that the health consequences of physical inactivity are problems of international proportions and that benefits to research and the capacity to effectively intervene are great. Determinants of physical activity; Evaluation of intervention; Challenges to international agreement; Domains of physical activity; Comparison of classes of activity and specific activities.

The article focuses on the speech disorders and speech therapy in patients suffering from Parkinson's disease. The symptoms of speech disorders in the patients suffering from the disease include decreased loudness, imprecise articulation and acceleration of words. Speech therapy is suggested for the patients suffering from symptoms of speech disorders in order to improve independence and quality of life of the patients. Various impairments in communication arising due to hypokinetic dysarthria, disfluent speech, facial muscle stiffness, bradykinesia and hypokinesia have been explained elaborately. Therapy regarding increasing of loudness is considered more effective. Amplification of speech through electronic devices is also suggested.

While movement disorders are frequently encountered after brain injuries, and may create a host of complicated problems for the clinician, only a few cases of Parkinsonism associated with hydrocephalus have ever been described in the literature. Parkinsonism like syndrome complicating hydrocephalus is a rare disorder, especially when associated with nontumoral aqueductal stenosis. Yet as this case report discusses, hdyrocephalus induced Parkinsonism may be responsive to levodopa-carbidopa administra tion. This report describes a perplexing case of persistent akinesis following corrective surgery for aqueductal stenosis and the subsequent response to levodopa carbidopa administration. We present the case of a 28 year old male with a history of non tumoral aqueductal stenosis diagnosed at age 12. As a child, he underwent a ventriculo peritoneal shunt placement for obstructive hydrocephalus followed by multiple shunt revisions over the next several years. Sixteen years after his initial shunt placement, the patient presented with a decline in mental status. A third ventriculocisternostomy was performed rather than another shunt revision. Following surgery, the patient remained obtunded, and displayed profound hypokinesis, best described as freezing in movement. Upon admission to a rehabiliation unit 2 weeks later, he had made only minimal progress. A SPECT single photon emission computed tomography brain scan revealed decreased basal ganglia perfusion. Levodopa carbidopa therapy was initiated and within 2 weeks, the patient showed improvement in speed of movement, facial expres sion and verbal output. Eight weeks later, the patient could independently complete his basic activities of daily living and demonstrated little, if any, disordered movement. This report illustrates how dopaminergic agents may be useful in cases of hypokinesis following corrective surgery for aqueductal stenosis. SPECT may further aid in the diagnosis and management of Parkinsonism like syndromes in brain injuries. [ABSTRACT FROM AUTHOR]

Highlights the 2003 Annual Meeting of the American Academy of Kinesiology and Physical Education in Pine Mountain, Georgia. Focus on the relationship of obesity to physical inactivity; Names of speakers; Emphasis on the importance of physical activity centered programs in improving the health of overweight individuals.

The article talks about apraxia of speech as a motor speech disorder which is a progressive neurodegenerative disease. A case of an elderly female is presented who was affected by apraxia of speech carrier of C90rf72 mutation. It was diagnosed that speech problem was due to bradykinesia and altered prosody.

The article presents a case study of a 26-year-old pregnant woman presented with acute onset central chest pain associated with vomiting and palpitation. The patient underwent electrocardiography and coronary angiography which revealed mild hypokinesia and dissection of small obtuse marginal branch. The article discusses acute myocardial infarction in pregnant women caused by spontaneous coronary artery dissection (SCAD).

Abstract: Self-poisoning with alpha chloralose is frequent in Tunisia. Neurological signs are prominent involving myoclonic jerks and coma. Cardiac toxicity is not well known. We report the case of a 19year-old woman who ingested a chloralose rodenticide and was admitted to our intensive care unit. Four hours after admission she developed acute heart failure with pulmonary edema and elevated troponin. Echocardiography showed diffuse hypokinesia. Patient’s cardiac and respiratory status improved progressively and echocardiography performed 5days after was normal. Cardiac toxicity following acute chloralose poisoning is uncommon and potentially serious. Its mechanism is poorly understood. [Copyright &y& Elsevier]

Reveals that physical inactivity cost New Yorkers about $3 billion in 1998. Projected rise of the cost by 2002; Percentage who reported no or minimal activity; Role of exercise in reducing health care costs.

With adult obesity and inactivity on the rise, researchers are looking at all causes for American inactivity levels. One important aspect of life that researchers say contributes to inactivity is the layout of American communities. More and more Americans are finding it harder to walk in their communities, due to increased sprawl and traffic concerns. As a result; researchers are continuing to study the immense impact that community design can have on health and active living. In one such study, published in the "American Journal of Health Promotion" researchers used data from the U.S. Centers for Disease Control and Prevention to look at the health characteristics of more than 200,000 individuals living in 448 United States counties in major metropolitan areas.

Lack of physical activity is often viewed as a predictor of low-back pain (LBP), yet few studies have examined whether this is actually so. Physical inactivity has not been shown to place patients at increased risk of LBP. Patient data were derived from the Monitoring Project on Risk Factors for Chronic Diseases of those who resided in Maastricht, The Netherlands. Although physical inactivity does not predict LBP and carries no health effects for reducing the burden of LBP in the population, such a finding does not offer a reason to stop promoting leisure-time physical activity. It is generally accepted that exercise is good for LBP. Intuitively one would propose, therefore, that physical inactivity would be a definite predictor of LBP. This paper says otherwise.

Presents information on significant changes in body size and composition that have important effects on health and functional capacity. Age at which this occurs; Literature available on topic; How information was compiled.