In this article, we introduce a new class of generalized Humbert-Hermite polynomials of two variables. We are conscious that the present paper was inspired by a unified presentation of a class of two-variable Humbert's polynomials that generalize the well-known class of Gegenbauer, Humbert, Legendre, Chebycheff, Pincherle, Horadam, Kinnsy, Horadam-Pethe, Djordjevi'c, Gould, Milovanovi'c and Djordjevi'c, Pathan, and Khan polynomials. Also, we present well-known results by analyzing the particular values of the parameter. We give the surface representation of a generalized Humbert-Hermite polynomial using some particular values of the parameters. [ABSTRACT FROM AUTHOR]