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Road traffic collisions (RTCs) are a global public health concern; however, research on the impact of bereavement on families remains limited. A critical realist approach was adopted to explore experiences of families suffering bereavement following RTCs, using interviews with 14 participants in the United Kingdom (UK) who have lost a family member. Three key themes were identified: (1) worsening mental health following bereavement, (2) negative impact of an RTC-related bereavement upon family members, (3) limited support following an RTC. Findings highlighted the requirement for appropriate support for bereaved families, and outlined significant flaws within the UK legal system, sentencing, and treatment of families. [ABSTRACT FROM AUTHOR]

A novel map display concept named Mirror in the Sky (MitS) has been introduced to improve performance and reduce workload in navigation tasks. However, this display will be novel to most users and as such, an evaluation of MitS in comparison with more conventional map formats is warranted. This study investigated the effects of map display format (MitS vs. north-up and track-up maps) and user expertise on mental workload (MWL) and performance, using both soldiers (experts) and civilians (novices) as participants. Participants followed a prescribed route to a destination in a virtual environment (route following task) while also performing a secondary task (detection response task). Soldiers generally performed better than civilians. Soldiers reported a higher MWL with MitS than with the north-up map, whereas civilians reported a higher MWL with MitS than with the track-up map. Regardless of user expertise, there were performance and workload challenges with MitS, despite its potential. Practitioner summary: A new map display concept called Mirror in the Sky (MitS) was compared with two conventional map formats: a north-up and track-up map. The experiment tested soldier and civilian users in a route following task. Both groups got further into the route and had fewer obstacle collisions with north-up and track-up maps than they did with the MitS map. MWL measures generally indicated higher workload with MitS. Abbreviations: MitS: mirror in the sky; FFOV: forward field of view; AR: augmented reality; MWL: mental workload; VR: virtual reality; HF: human factors; HR: heart rate; HRV: heart rate variability; DRT: detection response task; DRDC: defence research and development Canada; VE: virtual environment; RT: response time; ANOVA: analysis of variance [ABSTRACT FROM AUTHOR]

The next generation of displays for soldiers may include augmented reality capabilities. One such display, called Mirror in the Sky (MitS), presents survey information in the upper visual field. Using a virtual reality simulation of a military reconnaissance scenario, we compared a MitS prototype to a familiar electronic 2D north-up map. Participants (24 soldiers) were told to follow a prescribed route, detect potential threats, and reroute around them. They also performed a secondary task as a measure of mental workload. At the end of the route, the soldiers were asked to recall the locations of threats and route changes. Participants made better reroute decisions with the north-up map than with MitS, although no differences were observed for threat detection or mental workload. They also scored higher on recall with the north-up map than with MitS. Practitioner Summary: An augmented reality navigation aid was compared to an electronic north-up map in a military reconnaissance scenario, in a virtual reality simulation. Participants made better route decisions and had better recall with the north-up map, but no mental workload differences were found between displays. [ABSTRACT FROM AUTHOR]

We are developing ovine models of spinal cord injury to test novel neuromodulation-based methods on spasticity. The hemisection has been reported in a number of large animal studies. Our aim is to duplicate a hemisection injury in the sheep. Our effort is explored here. Methods and Results: Three sheep underwent hemi-sectioning of the spinal cord. Quantitative gait analysis was completed both pre- and post-injury. While measurable differences in most of the 20 gait metrics were observed, relatively few were above the predicted thresholds based on error levels expected from the data. Variations in severity of injury across the three sheep were observed. Conclusions: The hemisection ovine model of spinal cord injury shows promise as a large-animal platform for developing new therapies for treating spinal cord injuries. While variability in injury severity was observed across animals, as has been observed with weight drop-based SCI models, the hemi-section approach has the advantages of procedural ease and reduced technical complexity. [ABSTRACT FROM AUTHOR]

Context. Prescription opioid abuse is a major public health concern and an ongoing epidemic in the United States. Loperamide is a widely available and inexpensive over-the-counter antidiarrheal with peripheral mu-opioid receptor activity. Online resources discuss the use of loperamide for the amelioration of withdrawal symptoms or recreational abuse. We describe the clinical course of 5 patients abusing loperamide, 3 of whom had life-threatening cardiac arrhythmias. Methods. In this observational case series, patients with cardiac arrhythmias or history of loperamide abuse with cardiac arrhythmias were identified; 5 patients were identified and 4 of the 5 patients were seen directly at the bedside. Clinical profile and outcome of patients is reported. Results. We report 5 patients with history of loperamide abuse; 3 of the 5 patients had life-threatening cardiac arrhythmias. One of the patients experienced a second life-threatening arrhythmia after he resumed loperamide abuse. Loperamide levels were obtained in 4 of the 5 patients and were at least one order of magnitude greater than therapeutic concentrations. Discontinuation of loperamide resulted in complete resolution of cardiac conduction disturbances. Conclusion. This case series describes several patients with cardiac conduction abnormalities and life-threatening ventricular arrhythmias temporally related to loperamide abuse. With the recent efforts to restrict the diversion of prescription opioids, increasing abuse of loperamide as an opioid substitute may be seen. Toxicologists should be aware of these risks and we urge all clinicians to report such cases to FDA Medwatch®. [ABSTRACT FROM AUTHOR]

The article presents a review paper titled "A randomized dose-finding study demonstrating the efficacy and tolerability of albiglutide in Japanese patients with type 2 diabetes mellitus." Topics discussed include chart depicting patient demographics and baseline characteristics, chart depicting change from baseline in exploratory values including homeostatic model assessment measure, and adverse events like diarrhea, colon cancer, and depression occurring in greater than 2 percent patients.

The aim of this article is to assess the role of Real Exchange Rate (RER) volatility on long-run economic growth for a set of 82 advanced and emerging economies, using a panel data set ranging from 1970 to 2009. With an accurate measure for exchange rate volatility, the results for the two-step system Generalized Method of Moments (GMM) panel growth models show that a more (less) volatile RER has a significant negative (positive) impact on economic growth. The results are also robust for different model specifications. [ABSTRACT FROM AUTHOR]

Purpose. To report physical, psychological and functional outcomes from a pilot study of a multi-disciplinary rehabilitation programme for post-polio syndrome (PPS). Method. Twenty-seven participants completed the nine-day programme and were available for re-assessment at three and six months. Physical outcome measures were muscle strength and endurance; psychological outcomes included illness perceptions (IPQ), depression and anxiety (HADS); functional outcomes were fatigue (HFS) and client-centred occupational performance and satisfaction (COPM). Results. There was no significant change at six months for muscle strength or anxiety. Significant improvements were recorded for exercise endurance, depression and levels of fatigue. A shift towards an endorsement that the patient's own behaviour could be important in symptom severity of PPS was seen. Five out of 24 participants demonstrated significant clinical changes in occupational performance and satisfaction on the COPM. Conclusions. Prolonged benefits were found for physical, psychological and functional outcomes. A qualitative study is planned to investigate the patient-reported benefits of attending the programme such as the support gained interacting with others with similar disability and in lifestyle adjustment such as pacing of physical activities. [ABSTRACT FROM AUTHOR]

Introduction. We report a case of a female neonate who developed respiratory depression following the unintentional administration of methylergonovine. The respiratory depression appeared to improve after the administration of bag mask ventilation, stimulation, and naloxone; and the baby was able to be managed without endotracheal intubation and prolonged positive-pressure ventilation. Case. A full-term female neonate was delivered vaginally without issue. Approximately 10 min after delivery, the infant was inadvertently administered 0.1 mg of methylergonovine intramuscularly instead of vitamin K. Thirty minutes later the child developed cyanotic extremities and respiratory depression with an oxygen saturation of 75%. Naloxone, 0.4 mg IM, was recommended to mitigate respiratory depression. Within 5 min the patient's respirations improved to 40 breaths per minute, cyanosis improved, and she began resisting ventilations and crying loudly. The child continued to improve and was back to baseline that evening. Discussion. Methylergonovine toxicity in neonates has been commonly associated with respiratory depression necessitating ventilatory support. In consideration of chemical structural similarity between methylergonovine and morphine, as well as signs/symptoms consistent with opioid-induced respiratory depression, naloxone was suggested. Conclusion. It appears that naloxone may reverse methylergonovine toxicity in neonates. The identification of a safe and potentially useful antidote to mitigate respiratory depression, potentially avoiding the need for intubation and more invasive interventions in this patient population is important. [ABSTRACT FROM AUTHOR]