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Patients with psychogenic nonepileptic seizure (PNES) who fail performance validity testing (PVT) may appear to produce non-valid cognitive profiles. Consequently, they may not get referred to treatment and events persist, with worsening disability and high resource utilization. As a result, we report pre- and post-treatment neuropsychological evaluation findings in a 59-year-old woman with a confirmed diagnosis of PNES established using video-EEG monitoring. At pre-treatment baseline neuropsychological evaluation, PNES events occurred weekly to daily. Performance was impaired across PVTs and across multiple cognitive domains. After behavioral intervention specific to PNES, these events substantially reduced in frequency to rare stress-induced flares. Post-treatment neuropsychological evaluation revealed marked improvement of most cognitive and behavioral scores from baseline, and valid PVT scores. We review predisposing, precipitating, and perpetuating factors for PNES and cognitive impairment in this case and discuss the patient's outcome from treatment. Effectively managing PNES events and dissociative tendencies while reducing unnecessary pharmacological interventions appears to have allowed this patient to function closer to her optimal state. This case illustrates the complexity of Functional Neurologic Disorder (FND) clinical presentation and challenges the assumption that suboptimal neuropsychological performance predicts poor treatment engagement and outcome. We showcase the reversibility of PNES and cognitive manifestations of FND using targeted psychotherapeutic interventions, which resulted in reduced disability and associated healthcare costs, as well as re-engagement in life. [ABSTRACT FROM AUTHOR]

Objective: While assessment of performance validity is essential to neuropsychological evaluations, use of performance validity tests (PVTs) in an epilepsy population has raised concerns due to factors that may result in performance fluctuations. The current study assessed whether specificity was maintained at previously suggested cutoffs in a confirmed epilepsy population on the Warrington Recognition Memory Test (WRMT) – Words and Test of Memory Malingering (TOMM). Method: Eighty-two confirmed epilepsy patients were administered the WRMT-Words and TOMM as part of a standardized neuropsychological evaluation. Frequency tables were utilized to investigate specificity rates on these two PVTs. Results: The suggested WRMT-Words Accuracy Score cutoff of ≤42 was associated with a specificity rate of 90.2%. Five out of the 8 individuals falling below the Accuracy Score cutoff scored 42, suggesting specificity could be further improved by slightly lowering the cutoff. The WRMT-Words Total Time cutoff of ≥207 seconds was associated with 95.1% specificity. A TOMM Trial 1 cutoff of <40 was associated with 93.9% specificity, while the established cutoff of <45 on Trial 2 and the Retention Trial yielded specificity rates of 98.6% and 100.0%, respectively. Conclusions: Our findings demonstrate acceptable performance on two PVTs in a select confirmed epilepsy population without a history of brain surgery, active seizures during testing, and/or low IQ, irrespective of various factors such as seizure type, seizure lateralization/localization, and language lateralization. The possible presence of interictal discharges were not controlled for in the current study, which may have contributed to reduced PVT performances. [ABSTRACT FROM AUTHOR]

Objective: This review sought to gain a comprehensive, up-to-date understanding of the epidemiology and cost and healthcare resource use (HCRU) burden of amyotrophic lateral sclerosis (ALS) in the US, at a patient and national level. Methods: A targeted literature review (TLR) to identify epidemiological evidence (prevalence, incidence, mortality, survival), and systematic literature review (SLR) to identify cost and HCRU data published since January 2016, were performed. MEDLINE databases and Embase searches were conducted in January 2021. Key congresses (2019–2020) and bibliographies of relevant SLRs were hand-searched. Two high-quality SLRs were reviewed for additional cost data published between January 2001–2015. Registry and database studies were prioritized for epidemiological evidence. To allow comparison between studies in this publication, only evidence from the US was considered, with costs inflated to the 2020/2021 cost-year and converted to US dollars. Results: Eight studies from the epidemiology TLR, and eighteen from the cost and HCRU SLR, were extracted. Reported ALS incidence in the US was ∼1.5 per 100,000 person-years, and point prevalence ranged from 3.84–5.56 per 100,000 population. Total US national costs spanned ∼$212 million-∼$1.4 billion USD/year, and variably consisted of direct costs associated with HCRU and indirect costs. Conclusions: The national cost of ∼$1.02 billion USD/year (estimated using a prevalence of 16,055 cases) best aligns with prevalence estimates found in the TLR (equating to ∼13,000–18,000 cases). However, large-scale, population-based studies are necessary to precisely assess US epidemiology of ALS and capture all costs needed to inform cost-effectiveness models and resource planning. [ABSTRACT FROM AUTHOR]

The piriform cortex (PC) is part of the olfactory system, principally receiving input from the lateral olfactory tract and projecting to downstream components of the olfactory network, including the amygdala. Based on preclinical studies, PC is vulnerable to injury and can be easily kindled as an onset site for seizures. While the role of PC in human epilepsy has been studied indirectly and the subject of speculation, cases of demonstrated PC seizure onset from direct intracranial recording are rare. We present a pediatric patient with drug-resistant focal reflex epilepsy and right mesial temporal sclerosis with habitual seizures triggered by coconut aroma. The patient underwent stereoelectroencephalography with implantation of olfactory cortices including PC, through which we identified PC seizure onset, mapped high-frequency activity associated with presentation of olfactory stimuli and performance on cognitive tasks, and reproduced habitual seizures via cortical stimulation of PC. Coconut odor did not trigger seizures in our work with the patient. Surgical workup resulted in resection of the patient's right amygdala, PC, and mesial temporal pole, following which she has been seizure free for 20 months without functional decline in cognition or smell. Histological findings from resected tissue showed astrogliosis and subpial gliosis. [ABSTRACT FROM AUTHOR]

Objectives: Drink counting has been found to be an effective protective behavioral strategy (PBS) to reduce alcohol consumption. However, little is known about attitudes to this strategy and barriers and facilitators to its use. The aim of this study was to explicate these factors and draw comparisons with less efficacious PBSs. Method: In Stage 1, 1,703 Australian drinkers were surveyed about their perceptions of five PBSs ("Count the number of drinks you have," "Drink slowly rather than gulping or sculling," "Refuse an alcoholic drink you are offered because you don't really want it," "Avoid trying to 'keep up' or 'outdrink' others," and "Decide not to exceed a certain number of drinks"). Respondents reported perceived believability, relevance, ease of use, effectiveness, barriers, and facilitators. In Stage 2, 10 focus groups were conducted with drinkers to identify potential methods of effectively promoting drink counting. Results: Overall, drink counting was rated less favorably than the less-efficacious PBSs, indicating a need to inform drinkers of the importance and feasibility of this strategy to encourage its use. The main identified barriers were a lack of awareness of the long-term harms associated with alcohol use, social factors (e.g., peer pressure), and difficulty counting when intoxicated. Participants suggested improving drinkers' understanding of alcohol-related harms and developing mechanisms to assist with counting. Conclusion: To encourage drink counting, information campaigns are needed to educate the community about the long-term risks of alcohol use. Evidenced-based mechanisms to facilitate drink counting may be welcomed by drinkers. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has both widened and exacerbated student equity issues in Australian higher education, just as it has increased economic and social disadvantage in the general population. This article identifies the immediate impacts of the pandemic on existing equity structures, mapping potential areas for research analysis and policy responses. Given the pervasive nature of COVID-19, it is proposed that a whole-of-system approach be used, and in addition to focusing on existing student equity categorisations, a holistic approach to understanding disadvantage over the university student life cycle is undertaken to ensure the response to this health crisis is both targeted and timely. The article identifies emerging repercussions of the pandemic that will drive long-term structural changes in Australian higher education, as well as the community and labour market. Based on these observations, the key challenges facing the student equity sector are identified and possible responses provided. [ABSTRACT FROM AUTHOR]

Background: Schizophrenia is a heterogeneous disorder with a burden that can vary greatly depending on the severity and the duration. Previous research has suggested that patients in the earlier stages of schizophrenia (typically first-episode schizophrenia) benefit from effective early treatment, however, a comprehensive review of the burden specifically in this population has not been undertaken. A systematic literature review was therefore conducted to characterize the clinical, economic, and humanistic burden, as reported in naturalistic studies of schizophrenia populations specifically at an early stage of disease in comparison with healthy controls, patients with chronic schizophrenia, and patients with other psychiatric disorders. Methods and materials: Searches were conducted in MEDLINE, MEDLINE In-Process, Embase, PsycINFO, and EconLit databases for records published between January 2005 and April 2019, and of relevant conference abstracts published between January 2014 and May 2019. Data were extracted from relevant publications and subjected to qualitative evaluation. Results: Fifty-two publications were identified for inclusion and revealed a considerable burden for early schizophrenia with regards to mortality, psychiatric comorbidities such as substance abuse and depression, poor social functioning, and unemployment. Comparisons with chronic schizophrenia suggested a greater burden with longer disease duration, while comparisons with other psychiatric disorders were inconclusive. This review uncovered various gaps in the available literature, including limited or no data on incarcerations, caregiver burden, and costs associated with early schizophrenia. Conclusions: Overall, the burden of schizophrenia is apparent even in the early stages of the disease, although further research is required to quantify the burden with chronic schizophrenia and other psychiatric disorders. [ABSTRACT FROM AUTHOR]

Educational and career aspirations can be shaped by the expectations of significant others, including parents, teachers and peers. This study examined career discussions with significant others and how discussions about university or vocational education supported post-high school pathways. A mediation model examined the role of gender, year level, and first-in-family status to the links between pathway discussions and career expectations. The main findings suggested that students who discussed university more frequently with others were more likely to expect to attend university post high school. Students who discussed vocational and educational training pathways reported they were more likely to pursue vocational education. Students from low socioeconomic status backgrounds reported high expectations of attending vocational education and low expectations of attending university. Students discussed career and academic pathways with parents and peers more than with teachers and counsellors. This research informs influencers as to the importance of timely career pathway discussions. [ABSTRACT FROM AUTHOR]

Using qualitative interview data, we examine the consistency of White residents' responses to questions about their preferences for the racial composition of their neighborhoods when comparing hypothetical showcards and maps of real neighborhoods in respondents' cities. This approach allows for an examination of how residents' preferences for real neighborhoods align with preferences for idealized neighborhoods and the explanations people give when describing their preferences for neighborhoods of color. Data come from qualitative interviews conducted in Buffalo, New York, and Ogden, Utah. [ABSTRACT FROM AUTHOR]

Normative reference data used for clinical interpretation of neuropsychological testing results are only valid to the extent that the sample they are based on is composed of "normal" individuals. Accordingly, efforts are made to exclude individuals with histories and/or diagnoses that might bias test performance. In this report, we focus on these features in active-duty military personnel because published data on computerized neurocognitive testing norms for this population have not explicitly considered the consequences of neurobehavioral disorders (e.g., PTSD, depression), which are prevalent in this population and known to affect performance on some cognitive assessments. We administered DANA, a mobile, neurocognitive assessment tool, to a large sample of active-duty military personnel and found that scores on self-administered psychological assessments negatively impacted a number of neurocognitive tests. These results suggest that neurobehavioral disorders that are relatively common in this population should be controlled for when establishing normative datasets for neurocognitive outcomes. [ABSTRACT FROM AUTHOR]

Undergraduate research experience has been shown to enhance student learning and improve persistence in science, technology, engineering, and mathematics (STEM). Researchers studying undergraduate research experiences have largely focused on student outcomes and have seldom investigated the outcomes of graduate and postdoctoral mentors. Here, we report a non-credit, year-long mentor professional development program designed for graduate students, postdoctoral scholars, and research staff in STEM. Mentors attended a series of six interactive and discussion-based workshops and mentored first-year undergraduate students in independent summer research projects. We report evaluation findings for three mentor cohorts using a combination of qualitative analysis of mentoring philosophies and quantitative assessment of pre- and post-surveys about mentoring objectives and skills. Results indicate that mentors gained self-efficacy in some objectives and skills. However, many other objectives and skills remained unchanged. We explore possible explanations for the lack of more broad-scale gains across survey items and present ideas for program improvement. [ABSTRACT FROM AUTHOR]

Interprofessional learning (IPL) aims to equip students for future interprofessional and collaborative practice. Involving students as IPL facilitators is becoming increasingly commonplace as an attempt to catalyse the necessary transformation of our workforce needed to deliver truly integrated and person-centred care. Evidence in the literature highlights the key role of trained facilitators in reaching successful IPL outcomes. Some guidelines are available as to how we train staff facilitators, but little evidence is available that describes how to appropriately prepare student IPL facilitators. The aim of this exploratory study was to investigate whether student IPL facilitators felt that they were sufficiently prepared for their role. Data in the form of open-ended text-based responses from student facilitators (n = 9) were collated after an intervention where student facilitators had been given the role of supporting IPL. Data were analysed using principles of thematic analysis. Three main themes emerged: i) building confidence; ii) purpose of IPL; iii) learning moments. Student IPL facilitators who took part in this study felt that they were adequately prepared for their role. Findings show that preparing students for IPL facilitation has similar, yet unique, components compared to the training staff. In particular, this study highlighted a need for student facilitators to receive further preparation to help build their confidence. Involving students as IPL facilitators has great potential in staff and students joining forces to equip students for future interprofessional and collaborative practice that can deliver high-quality care. [ABSTRACT FROM AUTHOR]

Sport is a context that provides positive developmental benefits to adolescents. However, these benefits are not distributed equally to all participants. This study examined whether the motivational constructs of attainment value and ability self-concept were related to positive developmental experiences in sport, and tested intensity of participation as a moderator of this relation. A sample of 1,628 students (954 grade 9, 674 grade 12) reported their developmental experiences in sport in two domains: identity formation and flow. Higher levels of attainment value and ability self-concept in sport were related to more identity and flow experiences. In addition, intensity of participation moderated the links between attainment value and identity and flow, and ability self-concept and identity, for older students. Placing higher value on sport was most strongly related to older students’ positive experiences at higher levels of involvement. This study contributes to understanding the role of individual differences in developmental experiences in sport. [ABSTRACT FROM PUBLISHER]

One principle underlying the use of the Word Memory Test (WMT) as an effort test is that with good effort, recognition scores above the cutoffs will be observed. However, to understand the limits of effort testing, it is necessary to study people known to have severe impairment and significant neuropathology involving memory structures. Goodrich-Hunsaker and Hopkins (2009) reported that three amnesic patients with bilateral hippocampal damage had severely impaired free recall of the WMT word list but passed the recognition subtests of the WMT, which are often called effort subtests. We tested two patients with surgical resections in the left anterior temporal region to treat chronic intractable epilepsy; both patients had suffered postoperative strokes. Patient A was a 15-year-old boy and Patient B was a 58-year-old woman. Despite destruction of the left anterior hippocampus and the parahippocampal gyrus and despite impairment of free recall, both cases passed the easy WMT effort subtests. These data reinforce previous findings that people with severe impairment of free recall will score much higher on the verbal recognition memory subtests than on the more difficult memory subtests. Even severe memory impairment and=or removal of hippocampal areas do not necessarily lead to failure on the easy WMT recognition subtests. [ABSTRACT FROM AUTHOR]

Peer-led small-group learning has been used quite extensively in the US to enhance performance and retention of undergraduate students in science, math, and engineering classes. This study presents the results from an evaluation of a peer-led small-group programme at a research university in the US over a 10-year period across five disciplines (biology, chemistry, engineering, physics, and mathematics) and seven courses. Data suggest the programme had a positive impact on participants' grades in five of the seven courses and on retention in the four courses that require students to take a course sequence. Effects of the programme were investigated across gender and ethnic groups. Participants benefited from the programme regardless of their gender or ethnicity. However, effect sizes were often larger for students from underrepresented groups. This was particularly true for course retention, where effect sizes for females were larger than those for males in four courses. [ABSTRACT FROM PUBLISHER]

Participants with psychogenic non-epileptic seizures (PNES) who fail symptom validity testing (SVT) perform worse on neuropsychological testing than those who do not, consistent with results found in participants with different clinical presentations (e.g., mild traumatic brain injury). However, little is known about how variables typically associated with SVT failure in other populations (e.g., the presence of financial incentives, exaggerated report of psychopathology) correlate with SVT failure in participants with PNES. Likewise the relationship between SVT failure and reported abuse, one of the most frequently described demographic characteristics of the PNES population, has not been examined. We found that failure on the Word Memory Test (WMT) in 91 participants with PNES was strongly associated with reported abuse but, contrary to expectations, was not associated with the presence of financial incentives or severity of reported psychopathology. These results indicate that the factors driving WMT failure may differ significantly in participants with PNES in ways that are potentially clinically relevant. [ABSTRACT FROM PUBLISHER]

The Word Memory Test (WMT) is a common measure of symptom validity. To investigate the effects of acute benzodiazepines on WMT scores, oral lorazepam 2 mg (LOR) and placebo were administered 1 week apart in a randomized, double-blind, placebo-controlled, crossover study. A total of 28 participants completed the study and were administered the WMT during each drug condition. Within-participant comparisons of LOR vs placebo revealed significant LOR effects for Immediate Recognition (p = .007) and Consistency (p = .019), but not Delayed Recognition (p = .085). Significant LOR effects were present for Reaction Time Measures (Immediate Recognition RT, p = .013; Delayed Recognition RT, p = .001; Multiple Choice RT, p = .011) and Delayed Memory scores (Multiple Choice, p = .007; Paired Associates, p = .029; Free Recall, p = .001). A pattern similar to crossover results was detected for LOR vs placebo between-group differences for initial test assessment scores. When examined using publisher recommended cut scores for the principal WMT measures, there were six participants failing the WMT during initial LOR testing; all six subsequently performed in the normal range upon retesting with placebo. One participant failed WMT during placebo and obtained passing scores during LOR. These data indicate that multiple WMT measures may be affected by acute LOR dosing, and provide additional evidence that potential latent variables and their effects on both SVT performance and cognitive function should be part of the clinical decision-making process. [ABSTRACT FROM AUTHOR]

We investigate the possibility of implementing coherent anti-Stokes Raman spectroscopy (CARS) with a single laser beam passed through a one-dimensional scattering object. The effect of the random scattering is emulated by shaping the laser pulses with a spectral mask corresponding to the transmission spectrum of a random layered medium. Raman resonances are retrieved through correlation analysis of the CARS spectrum. We study the effect of the scattering parameters on the resolution of the method, and show that improvement of the spectroscopic sensitivity can be achieved by compensating the phase distortions introduced by the scatterer. [ABSTRACT FROM AUTHOR]

Personal response systems (PRS)-also called student response systems (SRS), or more commonly, 'clickers'-can be a catalyst for transformation of a learning environment from one of silence to one rich in dialogue and interaction. But how is this transformation achieved? In this paper, we present three case studies of instructors who use PRS in undergraduate science and math classes at a research-intensive institution in the Midwest, USA. All three instructors reported having to make significant adjustments to their teaching over time in order to transform their respective learning environments and fully realize the benefits of PRS. These adjustments included (1) modifying activities to overcome the tension between the students' desire for anonymity and the need for interactivity to enhance learning, and (2) revising PRS questions in response to student behavior. We contend that transformation of the environment with PRS is neither instantaneous nor straightforward. As such, faculty who introduce PRS to their classrooms may benefit from substantial pedagogical and technological support. Finally, we note that the ongoing feedback about student learning in the classroom that PRS provides may act as a powerful catalyst to transform faculty, moving them from teacher-centered conceptions and approaches to teaching to student-centered conceptions and approaches. [ABSTRACT FROM AUTHOR]

We present a 56 year-old, right-handed, congenitally deaf female who exhibited a partial Balint's syndrome accompanied by positive visual phenomena restricted to her lower right visual quadrant (e.g., color band, transient unformed visual hallucinations). Balint's syndrome is characterized by a triad of visuo-ocular symptoms that typically occur following bilateral parieto-occipital lobe lesions. These symptoms include the inability to perceive simultaneous events in one's visual field (simultanagnosia), an inability to fixate and follow an object with one's eyes (optic apraxia), and an impairment of target pointing under visual guidance (optic ataxia). Our patient exhibited simultanagnosia, optic ataxia, left visual field neglect, and impairment of all complex visual-spatial tasks, yet demonstrated normal visual acuity, intact visual fields, and an otherwise normal neurocognitive profile. The patient's visuo-ocular symptoms were noticed while she was participating in rehabilitation for a small right pontine stroke. White matter changes involving both occipital lobes had been incidentally noted on the CT scan revealing the pontine infarction. As the patient relied on sign language and reading ability for communication, these visuo-perceptual limitations hindered her ability to interact with others and gave the appearance of aphasia. We discuss the technical challenges of assessing a patient with significant barriers to communication (e.g., the need for a non-standardized approach, a lack of normative data for such special populations), while pointing out the substantial contributions that can be made by going beyond the standard neuropsychological test batteries. [ABSTRACT FROM AUTHOR]

The purpose of this article was to determine opinions on the use of abstinence only versus comprehensive sex education by registered voters in South Carolina. A cross-sectional, random-digit dial sample was utilized. Approximately 81% of respondents indicated support for sex education that emphasizes abstinence but also teaches about the benefits and importance of using contraceptives to prevent pregnancy and/or sexually transmitted diseases. Results suggest that registered voters in South Carolina support teaching a comprehensive approach to sex education and favor a variety of sex education topics, regardless of political ideology, religion, or parental status. [ABSTRACT FROM AUTHOR]

The ISCOMATRIX™ adjuvant has antigen-delivery and -presentation properties, as well as immunomodulatory capabilities that combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of subclasses of antibodies as well as both CD4+ and CD8+ T cells. A range of ISCOMATRIX vaccines (ISCOMATRIX adjuvant combined with antigen) have been evaluated in clinical trials. The results of these completed and ongoing studies indicate that the ISCOMATRIX adjuvant is safe and generally well tolerated and increases the vaccine immune responses. [ABSTRACT FROM AUTHOR]

Provides information on the emerging Christian Church. Identification of the forms of the emerging church; Background of the emerging church; Issues concerning practical theology and ecclesiology.

Relationships among perceived life satisfaction, perceptions of body weight, and dieting behaviors were examined in a statewide crosssectional study of public high school adolescents in South Carolina (N = 5,032). The Centers for Disease Control (CDC) Youth Risk Behavior Survey and the Brief Multidimensional Students’ Life Satisfaction Scale were utilized for this study. Adjusted logistic regression analyses and multivariate models constructed separately (via SUDAAN), revealed that perceptions of overweight, perceptions of underweight, having dieted to lose weight, having vomited or used laxatives to lose weight, and taking diet pills were significantly related (p [ABSTRACT FROM AUTHOR]

Normative data for a healthy sample of older adults (n=108) ranging in age from 60 to 96 are provided for the Cognistat, a mental status exam previously known as the neurobehavioral Cognitive Status Examination (NCSE). A Cognistat Composite Score is also introduced that is intended to be used as a marker of general cognitive impairment, allowing the Cognistat to be used to match patients in terms of severity of their cognitive dysfunction. The "screen and metric" approach of the Cognistat was abandoned in order to improve the reliability and standardization of this measure by administering the entire metric to all patients. The impact of demographic variables on Cognistat performance was examined, demonstrating that both age and education contribute uniquely to a number of Cognistat subtests as well as the Cognistat Composite Score. This study highlights the importance of matching an examinee's demographic background to the normative sample with which his or her test score is being compared. Normative data were stratified accordingly by age and by both age and education. Current results indicate that the Cognistat is sensitive to normal aging and promises greater sensitivity to the impact of age than the commonly employed Mini-Mental State Examination (MMSE). [ABSTRACT FROM AUTHOR]

This study integrates aspects of cognitive and social contextual approaches to understanding the practice of safer sex. Study participants were 398 unmarried college students attending one of two institutions of higher education in Texas. As predicted, individuals who perceived more cooperation from their sexual partner to practice safer sex were significantly more likely to do so than those who saw their partners as uncooperative. Especially important, as predicted, partner cooperation also moderated the relationship between cognitive and behavioral predictors and safer sex. These moderation findings demonstrate that partner cooperation limits the range of operation of psychological factors that have been shown in previous research to play a significant role in deciding to practice safer sex. [ABSTRACT FROM AUTHOR]

Background: During the COVID-19 pandemic, caregiving responsibilities may have been associated with increased substance use.Objectives: To characterize substance use to cope with stress and willingness to seek help among (i) parents, (ii) unpaid caregivers of adults, and (iii) parent-caregivers.Methods: Data were analyzed for 10,444 non-probabilistic internet-based survey respondents of the COVID-19 Outbreak Public Evaluation (COPE) initiative (5227 females, 5217 males). Questions included new or increased substance use, substance use in the past 30 days to cope, insomnia, mental health, and willingness to seek help.Results: Nearly 20% of parents and unpaid caregivers of adults each reported new or increased use of substances to cope with stress or emotions; 65.4% of parent-caregivers endorsed this response. Compared to non-caregivers, all caregiver groups had higher odds of new or increased use of substances, with parent-caregivers showing the largest effect size (aOR: 7.19 (5.87–8.83), p < .001). Parent-caregivers had four times the adjusted odds of using drugs other than cannabis (aOR: 4.01 (3.15–5.09), p < .001) compared to non-caregivers.Conclusions: Caregivers may initiate or increase substance use as a coping strategy when under stress. The higher odds of substance use underscores the importance of efforts to screen for sleep disturbances and adverse mental health symptoms, particularly among parent-caregivers. Clinicians may consider asking patients about family situations more broadly to help identify people who may be experiencing stress related to caregiving and, if indicated, offer treatment to potentially alleviate some of the risks. [ABSTRACT FROM AUTHOR]

Estimates of elapsed time were obtained from 53 patients with unilateral temporal lobe epilepsy (Left TLE = 27; Right TLE = 26) following Wada (intracarotid amobarbital) assessment. After resolution of drug effects, patients were asked to estimate how much time had passed since amobarbital administration. Estimates were also obtained from 24 healthy control subjects using the same cognitive tasks over a similar time frame. Elapsed time was significantly underestimated by both left and right TLE groups following right hemisphere injection. In addition, there was an interaction effect involving patient group, side of injection, and sequence of injection. Left TLE patients, consistent with normal controls, made more accurate time estimates when they could anticipate the estimation task following the second amobarbital administration. More accurate time estimates, however, occurred only when left hemisphere injection was second in sequence. In contrast, right TLE patients did not improve regardless of the order of injection. These results suggest that right hemisphere function plays a critical role in the accuracy of time estimations of intermediate temporal duration and that interhemispheric interaction may be required to make accurate retrospective temporal judgments. These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network. [ABSTRACT FROM AUTHOR]

The sensitivity of 6- versus 12-trial versions of the Verbal Selective Reminding Test (VSRT) to the material-specific memory deficits that are often observed in patients with lateralized temporal lobe (TL) impairment was investigated in 84 patients with complex partial seizures of temporal lobe origin (left = 45; right = 39). Patients with left-TL impairment tended to perform worse than patients with right-TL impairment on both long-term storage (LTS) and continuous long-term retrieval (CLTR) using either 6- or 12-trial versions. When employed to classify individual patients, comparable classification was obtained using either 6- or 12-trial formats. These results indicate that a shortened 6-trial format may be employed without any significant loss of sensitivity to left-TL impairment. [ABSTRACT FROM AUTHOR]

Because untreated arteriovenous malformations (AVMs) frequently result in some form of permanent neurological complication, treatment of AVMs is aggressively pursued A relatively new treatment consists of sending micropellets into blood vessels supplying the AVM core to block blood flow and "shrink" the AVM When vessels supplying the AVM are thought to also irrigate vital portions of brain, evaluations of neurobehavioral function after injection of amobarbital into intracranial vessels (Wada testing) may be performed to prevent significant complications folIowing embolization This study details our preliminary experience with Wada testing and electroencephalography (EEG) prior to AVM embolization in seven patients Neurobehavioral functions were continuously monitored after injection of 50-75 mg of amobarbital into target cerebral vessels No change in sensorimotor, cognitive, or EEG functions were detected in any of the superselective Wada examinations Embolization was performed following all negative Wada evaluations The only irreversible complication after embolization was a superior quadrantanopia No other permanent neurobehavioral sequelae resulted from embolization These preliminary findings suggest that simultaneous Wada/EEG monitoring may be useful in predicting neurobehavioral complications prior to AVM embolization. [ABSTRACT FROM AUTHOR]

Demonstrates limiting forms of the Polya-Eggenberger probability mass function. Use of recurrence formulas; Hypergeometric, beta binomial, binomial, negative binomial, Poisson, logarithmic and geometric limiting forms.

The impact of a required college health and physical education course on selected health knowledge, attitudes, and behaviors of alumni was evaluated. The design was a cross-sectional study (mail out/mail back survey) using a stratified random sample of 2,000 college alumni. The overall response rate was 50%. Results were analyzed by college of graduation (college with a required health/physical education course versus no required course). Alumni who took the course were more likely to know their blood pressure, blood cholesterol, and recommended dietary fat intake than the comparison group were. They also reported that the course positively influenced their attitudes toward exercise, eating, and smoking They were more likely to engage in aerobic exercise and less likely to smoke; and they had lower intakes of dietary fat, cholesterol, and sodium. The results suggested that a required college course enhanced selected health-related knowledge, attitudes, and behaviors of alumni. [ABSTRACT FROM AUTHOR]

An algorithm is presented for nonlinear least squares estimation in which the parameters to be estimated can be regarded as all nonlinear (the traditional approach) or reclassified as linear-nonlinear. The theoretical basis for the reclassification approach is given and examples are presented which allow a comparison of the all nonlinear to the linear-nonlinear method employing two widely used iterative techniques, Hartley and Marquardt. The reclassification method reduces the dimensionality of the vector of iterants and thus the number of initial guesses to be made. Improved results (less iterations and computer run time) are obtained for the linear-nonlinear method when using the Hartley technique, but are not when using the Marquardt technique. [ABSTRACT FROM AUTHOR]

Focuses on the statistics in the United States. Remarks on the null distribution of Durbin's test statistics; Complexity in the application of the asymptotic procedure; Computation of the null distribution.