1. Does resistance training ameliorate cancer-related fatigue in cancer survivors? A systematic review with meta-analysis.
- Author
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Gray, Luke, Sindall, Paul, and Pearson, Stephen J.
- Subjects
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MEDICAL information storage & retrieval systems , *CINAHL database , *BREAST tumors , *META-analysis , *PROSTATE tumors , *DESCRIPTIVE statistics , *RESISTANCE training , *DOSE-response relationship in biochemistry , *SYSTEMATIC reviews , *MEDLINE , *STRENGTH training , *PRE-tests & post-tests , *ENDOMETRIAL tumors , *MEDICAL databases , *QUALITY of life , *CANCER patient psychology , *CANCER fatigue , *HEALTH outcome assessment , *ONLINE information services , *WEIGHT lifting , *COMPARATIVE studies , *CONFIDENCE intervals , *SENSITIVITY & specificity (Statistics) , *CANCER patient rehabilitation - Abstract
Cancer-related fatigue (CRF) is unrelenting. As neither rest nor sleep ameliorates cognitive, emotional, and physical symptoms, quality of life is diminished. This study examines resistance training (RT) effectiveness on CRF in cancer survivors. The secondary aims were to identify the dose-response relationship of RT frequency, intensity, and volume on CRF in different cancer survivor populations. Systematic searches via numerous databases for RCTs were performed in June 2022. Patient-reported outcome measures (PROM), were analysed, pre-to-post intervention, using a random-effects model. The Physiotherapy Evidence Database (PEDro) scale informed methodological quality assessment. Eight studies were included (cancer survivors: breast (BCS) = 5; endometrial (ECS) = 1; prostate (PCS) = 2). Overall, RT interventions ≥ 6 weeks elicited large significant reductions in CRF for FACIT-F (SMD = 0.932, p = <0.001) and moderate significant reductions in CRF for PFS-R (SMD = −0.622, p = 0.004). Main findings indicate that RT ameliorates CRF, especially in BCS; however, individualised approaches should be advocated. Supervised training elicited the greatest positive outcomes, thus should be a pivotal part of the cancer rehabilitation pathway. Future studies should be adequately powered, undertake discrete analyses of different cancer types, and investigate chronic RT effects. Cancer-related fatigue (CRF) is debilitating and distressing, leading to reduced quality of life and function in cancer survivors. Considerable heterogeneity exists in disease histology and clinical patient presentation. Individualised resistance training (RT) is an effective, safe, and accessible intervention to mitigat:e fatigue levels, thus aid function, most notably in breast cancer survivors [ABSTRACT FROM AUTHOR]
- Published
- 2024
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