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Magnetic drug targeting (MDT) is an application in the field of targeted drug delivery in which magnetic (nano)particles act as drug carriers. The particles can be steered toward specific regions in the human body by adapting the currents of external (electro)magnets. Accurate models of particle movement and control algorithms for the electromagnet currents are two of the many requirements to ensure effective drug targeting. In this work, a control approach for the currents is presented, based on an underlying physical model that describes the dynamics of particles in a liquid in terms of their concentration in each point in space. Using this model, the control algorithm determines the currents generating the magnetic fields that maximize the particle concentration in spots of interest over a period of time. Such an approach is computationally only feasible thanks to our innovative combination of model order reduction with the method of direct multiple shooting. Simulation results of an in-vitro targeting setup demonstrated that a particle collection can be successfully guided toward the targeted spot with limited dispersion through a surrounding liquid. As now present and future particle behavior can be taken into account, and non-stationary surrounding liquids can be dealt with, a more precise and flexible targeting is achieved compared to existing MDT methods. This proves that the presented methodology can bring MDT closer to its clinical application. Moreover, the developed model is compatible with state-of-the-art imaging methods, paving the way for theranostic platforms that combine both therapy as well as diagnostics. [ABSTRACT FROM AUTHOR]

Low socio-economic status has been consistently identified as a primary risk factor for sexual and reproductive health violations affecting young women. This study shows how poverty interacts with gender power relations to impact upon adolescent girls' sexual and reproductive lives in Western Uganda. Qualitative research with 147 participants was undertaken. This comprised 59 in-depth interviews and 11 focus group discussions with groups of 12–14 year-old young women, teachers and parents. Data were analysed manually using open and axial coding, and conclusions were generated inductively. Findings reveal that young women are restricted in exercising their sexual and reproductive rights not only by poverty and unequal gender relations, but also by corruption and poor service provision. In contrast to interventions using liberal rights-based approaches, we advocate the use of a 'marketplace of options' since access to sexual and reproductive health services is very limited for poor girls and not evenly distributed. Moreover, while poverty and unequal gender relations render girls vulnerable to sexual coercion and violence, the criminal justice system is often weak, leaving victims powerless. Investment in appropriate resources and inclusive and affordable access to justice is essential to advance young women's sexual and reproductive health. [ABSTRACT FROM AUTHOR]

The successful implementation of sexuality education policy for young people has been shown to depend on a sound legislative and institutional framework. This article shows that both institutional factors and contextual obstacles have impeded the implementation of sexuality education policy in Uganda. Qualitative research techniques were employed in the form of systematic document reviews and extensive field-work with 64 participants, of which 32 were in-depth interviews with policymakers and key stakeholders in Kampala and Mbarara districts. In addition, four focus group discussions (n = 32) were conducted with teachers. The analysis was carried out thematically and manually, using open and axial coding. It was found that policy success was primarily limited by two broad factors: firstly, by institutional weaknesses such as a lack of capacity, inadequate financial commitment, poor coordination between relevant ministries and ineffective monitoring, and regulatory frameworks; secondly, by social, cultural and religious norms that give informal power to religious and cultural leaders. Two strategies are suggested as potential ways forward: (i) a commitment to both the human and financial resources needed to monitor adolescent sexual, and reproductive health programmes, but more importantly (ii) the initiation of negotiations with cultural and religious leaders to yield more positive outcomes. [ABSTRACT FROM AUTHOR]

The female body has been in the foreground of nation-building in Iran especially since the 1930s projects of modernization, when unveiling women and adaptation to Western clothing became a crucial factor of bolstering modern Iranian national identity as opposed to a religion-based national identity. After the 1979 Revolution, the Islamic dress code became compulsory and female imagery depicting modesty and piety became a source of national identity. Although the representation of women's bodies in nationalist discourses has been subject of different studies, women's representation in official online outlets is still understudied. This article discusses how women's bodily appearance and representation in official online outlets feed into the nationalist discourses in Iran. Three key cases between 2014 and 2017 are addressed: (i) actress Leila Hatami kissing a man at the 2014 Cannes Film Festival; (ii) the public debate on women's entrance to sports stadiums in 2014–2015; (iii) the public revelation of actress Taraneh Alidoosti's tattooed forearm in 2016. Data were collected from multiple Iranian official online platforms and a critical discourse analysis was undertaken to analyse different forms of discursive articulation regarding women's bodies and national identity. Drawing on feminist literature inspired by the Foucauldian concept of biopolitics, the article discusses the ways in which women's bodies are discursively constructed to illustrate a uniform Islamic nationalistic discourse. [ABSTRACT FROM AUTHOR]

Humanitarian aid projects associated with the emergence of refugee camps within European territories are generally perceived as apolitical. Scholars however, are increasingly questioning this view, pointing to many, often untold, ways in which humanitarianism interacts with the politics of migration and border enforcement. This article examines the case of a temporary refugee camp set up in Brussels in September 2015. We show how organizational and spatiotemporal particularities, as well as media framing of the humanitarian assistance, led to controversy, civil initiatives, and hyperpoliticization, eventually calling the state to take responsibility for the refugees, but simultaneously silenced other explicit political responses. [ABSTRACT FROM AUTHOR]

Purpose: People have the right to freedom of opinion and expression, as defined in Article 19 of the Universal Declaration of Human Rights. Higher education plays a major role in helping students to develop and express their own opinions and, therefore, should be equally accessible to all. This article focuses on how students judge the accessibility to oral instruction in higher education listening contexts. Method: We collected data from 191 students in higher education by means of a questionnaire, addressing understanding speech in different types of classrooms and various educational settings. Result: In lecture halls, understanding speech was judged to be significantly worse than in smaller classrooms. Two important negative factors were identified: background noise in classrooms and lecture halls and the non-use of a microphone. Conclusions: In lecture halls students achieve good or excellent speech perception only when lecturers are using a microphone. Nevertheless, this is not a standard practice. To achieve genuine inclusion in tertiary education programs, it is essential to remove acoustic barriers to understanding speech as much as possible. This study is a first step to identify communication facilitators to oral higher education instruction, for students with hearing loss or communication impairment. [ABSTRACT FROM AUTHOR]

Using mixed methods that combined participant observation and semi-structured in-depth interviews, this study looked at changing practices and shifting meanings of female genital cutting among the Maasai people in Tanzania. The findings suggest that an increasing social pressure to abandon female genital cutting has inspired the hiding of the practice, causing the actual cutting to become detached from its traditional ceremonial connotations. This detaching of cutting from ceremony has created a shift in meanings: the ceremony still carries the meaning of passage into adulthood, while the cutting seems to function as a way of inscribing Maasai identity into the body. The detaching of genital cutting from ceremony offers those willing to continue the practice the opportunity to do so without being prosecuted, and those unwilling to undergo or perform the practice the opportunity to evade it by faking the cutting without being socially sanctioned for it. Findings also suggest changing attitudes towards the practice among the younger generation as the result of education. Maasai culture and the practice of female genital cutting are not static but actively challenged and reinterpreted from within the community, with formally schooled and women taking up leading roles in reshaping gender norms. [ABSTRACT FROM PUBLISHER]

The concept of honour and associated phenomena have often been associated with a gender ideology which forces women to obey restrictive moral prescriptions; accordingly, honour has sometimes been understood as unilaterally negative for women's well-being. A critical analysis reveals, however, how reductionist understandings of honour flow from a culturalist framing of issues, such as honour-related violence, thereby failing to grasp the complexity of women's responses when socialized with traditional notions of honour. Based on the theoretical reflections of authors such as Phillips (2007), Ewing (2008) and Abu-Lughod (2011) and drawing on the narratives of two women of Moroccan descent in Belgium, this article aims to demonstrate how an analysis grounded in intersectionality theory and based on Bourdieu's concept of ‘habitus’ may provide a deeper insight into the complexities of women's lived experiences of honour. Rather than departing from fixed understandings of honour, it is argued that its content and meaning are fluid and changeable. Although closely linked with cultural ideologies and socialization processes which shape individual lives and experiences, these do not prevent personal choice and interpretation which, according to the positioning of individuals and their families in and outside their communities, may produce cultural continuity or bring about change. [ABSTRACT FROM AUTHOR]

Objectives The auditory speech sounds evaluation 2009 test battery for assessment of speech pitch perception is presented. It was designed to (a) assess perception of pitch in linguistic contexts without the confounds of secondary acoustic cues, (b) be usable with listeners from different language backgrounds, and (c) be suitable for use in a clinical setting. The need for this test battery arises from increased awareness of the importance of prosody in clinical practice, and the development of methods for improving pitch perception in listeners with profound hearing losses. Methods Identification and discrimination tasks based on linguistic contexts were developed to establish listeners' just noticeable differences (JNDs) for pitch changes. Stimuli were pseudosentences and pseudowords based on speech from a female speaker, overlain with stylized pitch contours. Target pitch excursions were varied from the 200 Hz baseline to a maximum of 349 Hz. Ninety normal-hearing listeners participated in test validation that assessed goals (a)-(c), established test-retest reliability, and gathered normative data. Results The JNDs on non-linguistic, control tasks were lower than on linguistic ones, showing that non-linguistic tasks may overestimate pitch perception in speech. Listeners from different language backgrounds scored comparably on most linguistic tasks, and test-retest differences were non-significant. Test usability as evidenced by task duration and subject experience seemed satisfactory for clinical use. [ABSTRACT FROM AUTHOR]

We revisit the peer-to-peer on-orbit satellite refueling problem, in which the maneuvering satellites are allowed to interchange their orbital positions. We show that the problem is computationally hard by reducing it to a special case of the three-index assignment problem. On the positive side, we show that the size of instances in practice is such that a state-of-the-art integer programming solver is able to find globally optimal solutions in little computing time. [ABSTRACT FROM AUTHOR]