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Start Over Descriptor "Chiral intermediate" Publisher taylor & francis ltd
1 results on '"Chiral intermediate"'

1. Efficient Synthesis of ( S )-3-(4-Fluorophenyl)morpholin-2-one, a Key Chiral Intermediate of Aprepitant.

Author

Wang, Song-Mei

Subjects
*PHENYL compounds, *CHIRALITY, *INTERMEDIATES (Chemistry), *CHEMICAL sample preparation, *HYDROGENATION
Abstract

A facile, economical, and practical method for the preparation of (S)-3-(4-fluorophenyl)morpholin-2-one [(S)-9] has been developed from ethyl 2-(4-fluorophenyl)-2-oxoacetate (7) in three steps through cyclization, hydrogenation, and resolution, providing a new and convenient access to the key intermediate of antiemetic drug aprepitant. [ABSTRACT FROM PUBLISHER]

Published
2015
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