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Your search keyword '"Cavalcante, Samir F. A."' showing total 3 results
Start Over Author "Cavalcante, Samir F. A." Publisher taylor & francis ltd
3 results on '"Cavalcante, Samir F. A."'

1. Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets.

Author

Almeida, Joyce S. F. D., Botelho, Fernanda D., de Souza, Felipe R., dos Santos, Marcelo C., Goncalves, Arlan da Silva, Rodrigues, Rodrigo L. B., Cardozo, Monique, Kitagawa, Daniel A. S., Vieira, Leandro A., Silva, Raphael S. F., Cavalcante, Samir F. A., Bastos, Leonardo da C., Nogueira, Mariana de O. T., de Santana, Priscila I. R., Brum, Juliana de O. C., Nepovimova, Eugenie, Kuca, Kamil, LaPlante, Steven R., Galante, Erick B. F., and Franca, Tanos C. C.

Published
2022
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2. Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators.

Author

Kitagawa, Daniel A. S., Rodrigues, Rafael B., Silva, Thiago N., dos Santos, Wellington V., da Rocha, Vinicius C. V., de Almeida, Joyce S. F. D., Bernardo, Leandro B., Carvalho-Silva, Taynara, Ferreira, Cintia N., da Silva, Angelo A. T., Simas, Alessandro B. C., Nepovimova, Eugenie, Kuča, Kamil, França, Tanos C. C., and Cavalcante, Samir F. de A.

Subjects
OXIMES, ACETYLCHOLINESTERASE, NERVE gases, ORGANOPHOSPHORUS compounds, CENTRAL nervous system, IN vitro studies
Abstract

Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a broad spectrum, are not effective towards all organophosphorus toxins, and have poor pharmacokinetics properties to allow them crossing the blood-brain barrier, hampering cholinesterase reactivation at the central nervous system. In this work, we designed and synthesised novel isatin derivatives, linked to a pyridinium 4-oxime moiety by an alkyl chain with improved calculated properties, and tested their reactivation potency against paraoxon- and NEMP-inhibited acetylcholinesterase in comparison to the standard antidote pralidoxime. Our results showed that these compounds displayed comparable in vitro reactivation also pointed by the in silico studies, suggesting that they are promising compounds to tackle organophosphorus poisoning. [ABSTRACT FROM AUTHOR]

Published
2021
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