Search

This paper considers maternal subjectivity and maternal identity development through our work in an urban clinical setting where women present for treatment during the perinatal period. Drawing on a rich tradition of psychoanalytic observational research and mother-infant communication research, which supported the relational turn, we aim to shift the lens from mothers as important to their baby's development, to maternal experiences as essential. Likewise, noting that a mother cannot exist without a baby, real or imagined, we consider the role of a baby in a mother's own development. Tracing roots of maternal subjectivity in psychoanalytic traditions, while also noting its absence, we hope to offer ways to formulate maternal identity that are clinically useful and grounded in research, and reflective of our contemporary positions. Case examples further illustrate the utility of narrative measures, including the Adult Attachment Interview, in clinical settings. [ABSTRACT FROM AUTHOR]

Empowering students to actively shape their learning is essential. Various student involvement models, such as design-based research, participatory design, and co-creation, emphasise students' growing role in shaping educational activities. Engaging students in course design, as seen in student co-creation, can enhance agency, improve the student experience, and boost outcomes. Considering this, we propose a systematic approach combining multi-criteria decision-making with constructive alignment theory to involve students as co-creators in course design. This approach aims to engage students in the course design process and co-create intended learning outcomes, which can be regarded as the primary participatory phase in developing a co-created course. By involving students, our approach aims to gain insight into their needs, prioritise their views, and guide the formulation of appropriate course specifications throughout the course design process. The approach is applied to a new multi-disciplinary engineering course, and the results are summarised following its corresponding steps. Students' feedback indicates that the approach positively influenced their motivation, engagement with course objectives, collaboration with teachers, and overall achievement of intended learning outcomes. This study's significance lies in its contribution to higher education, offering a more integrated and systematic approach to support co-creation between educators and learners in academic course design. [ABSTRACT FROM AUTHOR]

Balance and functional impairment could occur due to the weakness of the gastrocsoleus muscles in acute stroke patients. This study was planned to determine the muscle architecture and its relationship to balance and functional strength functional ability in patients with acute stroke. A cross-sectional analysis of 22 stroke patients (68.59 ± 8.16) was performed in this study. Gastrocnemius muscle thickness and cross-sectional area were significantly greater on the non-paretic than on the paretic sides (p = 0.004, p = 0.005, respectively). Partial correlation analysis showed that soleus muscle thickness and cross-sectional area was significantly correlated with Berg Balance Scale, Single Leg Stance Test, Five Times Sit to Stand Test and Tandem test results in the paretic side (r = 0.49–0.77, p < 0.05). The gastrocnemius muscle thickness of the non-paretic side had a significant relationship with balance (r = 0.45–0.65, p < 0.05). The muscle thickness and cross-sectional area of the soleus muscle on the paretic sides was significantly related with the functional strength and balance after stroke. It may be beneficial to develop clinical assessment and intervention programs focusing on distal plantar flexor muscle groups in order to improve the functional status and balance. [ABSTRACT FROM AUTHOR]

The researchers' aim was to evaluate the impact of laughter yoga on pregnancy symptoms, mental well-being, and prenatal attachment. They carried out this study on 85 pregnant women randomized in a maternity hospital in the Eastern Anatolia Region of Turkey. The researchers collected data using the Pregnant Introduction Form, Pregnancy Symptom Inventory (PSI), Warwick-Edinburgh Mental Well-being Scale (WEMWBS), and Prenatal Attachment Inventory (PAI). After applying the laughter yoga practice, they found that mental well-being and prenatal attachment levels were higher in pregnant women in the experimental group and the difference was statistically significant. Thus, they concluded that laughter yoga was an effective practice in reducing the frequency of pregnancy symptoms and limiting daily activities by pregnancy symptoms and increasing mental well-being and prenatal attachment levels. [ABSTRACT FROM AUTHOR]

There are limited studies on substance use in nurses. The importance of the role of nurse managers was emphasized in previous studies; however, there were no studies that revealed their experiences throughout the process. A qualitative design was used. The data were collected using a snowball method with purposeful sampling methods. The inclusion criterion was being a nurse manager who had worked with nurses who had used psychoactive substances. Interviews were conducted with a total of seven participants using a semi-structured interview form. Qualitative content analysis was performed after the interviews. As a result of the analysis of reports of individual in-depth interviews conducted with a total of seven participants, and examination of the literature regarding the issue, experiences of nurse managers who had worked with nurses with substance use were examined in three main themes − 1) identifying substance-using nurses, 2) interventions, and 3) feelings and opinions of nurse managers Nurse managers identifying the nurses with substance use and managing the process appropriately is the key point in ensuring that these nurses receive support and patient safety is provided without interruptions. Therefore it is important that the experience of nurse managers is investigated. [ABSTRACT FROM AUTHOR]

Objective The appropriate treatments for the different molecular subgroups of medulloblastomas are challenging to determine. Hence, this study aimed to examine the expression profiles of long non-coding RNAs (LncRNAs) to determine a marker that may be important for treatment selection in these subgroups. Methods Changes in the expression of LncRNAs in the tissues of patients with medulloblastoma, which are classified into four subgroups according to their clinical characteristics and gene expression profiles, were examined via reverse transcription polymerase chain reaction. Moreover, there association with patient prognosis was evaluated. Results The expression levels of MALAT1 and SNGH16 were significantly higher in patients with group 3 medulloblastoma than in those with other subtypes. Patients with high expression levels of MALAT1 and SNGH16 had a relatively shorter overall survival than those with low expression levels. Conclusions Patients with group 3 medulloblastoma have a high MALAT1 level, which is associated with poor prognosis. Therefore, MALAT1 can be a new therapeutic target in medulloblastoma. [ABSTRACT FROM AUTHOR]

A digital transformation is currently taking place in society, where people and things are connected to each other and the Internet. The number of connected devices is projected to be 28 Billion in 2025, and our expectations on digitalization set new requirements of mobile communication technology. To handle the increased amount of connected devices and data generated, the next generation of mobile communication technology is under deployment: 5G-technology. The manufacturing industry follows the digital transformation, aiming for digitalized manufacturing with competitive and sustainable production systems. 5G-technology meets the connectivity requirements in digitalized manufacturing, with low latency, high data rates, and high reliability. Despite these technological benefits, the question remains: Why should the manufacturing industry invest in 5G-technology? This study aims to determine the impact of 5G-technology on manufacturing performance; based on a mixed-methods approach including a modified TOPSIS method to ensure robustness of the results. The results show that 5 G-technology will mainly impact productivity, maintenance performance, and flexibility. By linking 5G-technology to the performance of the manufacturing system, instead of focusing on network performance, the benefits of using 5G-technology in manufacturing become clear, and can thus facilitate investment and deployment of 5G-technology in the manufacturing industry. [ABSTRACT FROM AUTHOR]

Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups. Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients. Results:IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8.24%) patients. TERT mutation and loss of ATRX/DAXX were associated with short overall survival (p < 0.001, p < 0.001, respectively). Patients carrying especially TERT C228T mutation had worse prognosis (p < 0.001). Six subgroups were obtained from the genetic analysis. Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p < 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p < 0.001). Conclusions: Our findings highlight that the presence of TERT C228T mutation and expression of MALAT1 can be used as primary targets during the follow-up of primary GB patients and in the development of new treatment strategies. [ABSTRACT FROM AUTHOR]

The aims of this study were to investigate the associations between impairments and imbalances in children's mental state talk, attachment security and abuse/neglect experiences, and to study how much of the variance in internalizing and externalizing problems was explained by mentalization problems. The sample included 100 Turkish children (M Age = 7.00 (SD = 2.01), 38% girls) referred to a outpatient psychotherapy clinic. Children were administered an attachment-based story stem task in order to code attachment security and different categories of mental state talk, including the extent of their direction (self vs other), balance, and appropriateness. Parents and teachers filled out socio-behavioral function scales. Findings indicated a significant positive association between externalizing problems and impaired mentalization. Internalizing problems were associated with mentalizing the other at the expense of one's own mental states and underusing emotions. Attachment insecurity and adverse experiences were associated with mentalization impairments and imbalances. Finally, underuse of emotions and self-focused mental state talk predicted internalizing problems and impaired mental state talk predicted externalizing problems at trend level of significance. Qualitative analyses supported the results, which suggest that whereas children with externalizing problems suffer from severe mentalization deficits, children with internalizing problems undermentalize about themselves and emotions. [ABSTRACT FROM AUTHOR]

Hydride generation atomic absorption spectrometry was used as a simple, sensitive, and economical method for the determination of cadmium at trace levels. This study includes a stepwise optimization of all parameters that have an impact on the production, transport, and atomization of cadmium hydride for rapid determination due to the unstable nature of the hydride produced. The cell temperature for atomization, pump period, and flow rate of carrier gas were varied, and the best conditions were defined to obtain lower detection limits. In addition, the acid and sodium borohydride concentrations were optimized since they directly affect the production of the cadmium hydride. Under optimum experimental conditions, the hydride generation efficiency was greatly enhanced to record optimized analytical signals. The accuracy of the method was determined by the analysis of a certified reference material, and the results were in good agreement with the certified value. A linear dynamic range for cadmium was observed from 0.10 to 2.0 µg/L. High sensitivity was obtained with a limit of detection of 0.029 µg/L. [ABSTRACT FROM AUTHOR]

As the literature on perinatal depression and anxiety grows, there is an increased need for dialogue among theoretical approaches for mother-infant mental health. This article describes a community mental health program incorporating a range of treatment models for pregnant and postpartum women experiencing issues during the transition to parenthood. Perinatal distress can affect parenting practices, from breastfeeding to health care access, creating the need for targeted, practical, and concrete interventions. Interventions that aim to foster secure attachment relationships and mentalization capacities can also help increase maternal sensitivity and attunement and joy in caregiving, and reduce withdrawn/hostile behaviors that may be associated with perinatal distress. The article describes psychotherapy with a mother and her newborn that began from a cognitive-behavioral approach and transitioned to a psychodynamic mentalization-focused treatment. Working principles and examples of two additional components of treatment, a group psychotherapy and research measures, are discussed. The case helps demonstrate how attachment theory can inform treatment and build a bridge between alternative approaches. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the multidimensional nature of maternal mental state talk with respect to children’s social-behavioral functioning in a low-income urban preschool sample. Maternal speech data were collected as mothers narrated a wordless picture book depicting a diverse set of mental states to their children (n = 130, 2-4 year olds). Dimensions of maternal mental state talk (i.e., type, direction, causality) were examined with the Coding System for Mental State Talk in Narratives. Approximately half of the sample consisted of higher-risk children who were identified as in need of clinical services by on-site clinicians. Results indicated that mothers’ diversity and causality of mental state talk, their acknowledgement of characters’ negative emotions, and talk about children’s cognitions and their own mental states were associated with children’s socially adaptive behaviors. On the other hand, mothers’ tendency to focus on children’s perceptions during the story-telling task (e.g., “see that?,” “look!”) was linked with lower social competence and internalizing problems. Mothers in the clinical sample used a significantly lower proportion of emotion words compared to mothers in the nonclinical sample. Results suggest that a picture book reading task might provide a cost-effective method for assessing and possibly modifying maternal mental state talk. [ABSTRACT FROM AUTHOR]

Parents’ ability to recognize children’s mental states and use mental state language in their interactions are associated with children’s mentalization, affect regulation, and symbolization in play. However, the relations among these constructs have not been investigated in school-age children with behavioral problems. This study examined the association between 53 Turkish mother-child and 40 father-child dyads’ mental state talk, children’s play characteristics, and behavioral problems at the beginning of psychotherapy. Results indicated that parents’ and children’s play-related mental state talk was associated with children’s interactive role-play, and mothers’ mental state talk was associated with children’s affect regulation in play. Moreover, mental state talk through pretend play was linked with fewer internalizing symptoms; yet a direct focus on children’s mental states out-of-pretend play was correlated with more behavioral problems, highlighting the multidimensional nature of the mentalization construct. These results are discussed taking into account the socio-cultural variations of the Turkish culture highlighting the unique characteristics of the parent-child play in context. The clinical implications point to the importance of parental and child mentalization within pretend play, that provide opportunities for affect processing, which could promote symptomatic improvement. [ABSTRACT FROM PUBLISHER]

Unmethylated O6-methylguanine-DNA-methyltransferase (MGMT) promoter leads to Temozolomide (TMZ) resistance in most of the glioblastoma multiforme (GBM) patients. We previously investigated the synergistic effect ofOlea europaealeaf extract (OLE) on TMZ cytotoxicity through modulating microRNA expression. To date, knowledge about the effect of OLE onMGMTmethylation is insufficient. The aim of the current study was to evaluate the potential modulating effect of OLE on the TMZ response of GBM tumors throughMGMTmethylation. Exposure to 1 mg/mL OLE caused a significant induction of CpG island methylation in theMGMTgene using Methyl quantitative PCR assay (P< 0.001). In WST-1 analysis, the use of 350 µM TMZ plus 1 mg/mL OLE significantly increased the TMZ response ofMGMTunmethylated cells (P= 0.003). Using the comet assay, the impact of 1 mg/mL OLE plus 350 µM TMZ on the formation of DNA strand breaks was significantly higher than that of 450 µM TMZ alone (P< 0.001) and Western blot analysis revealed that, when cells are treated with 1-mg/mL OLE, the total p53 protein levels tended to decrease. The results presented in this study uniquely demonstrated that OLE synergistically increased the TMZ response of GBM tumors by regulatingMGMTgene methylation and p53 expression. However, further studies to validate our findings are required. [ABSTRACT FROM PUBLISHER]

Spinal paragangliomas are rarely-observed neuroendocrine benign tumors in the extra-adrenal paraganglionic system. Primary spinal involvement is even rarer. Radiologic differential diagnosis is not easy. This paper presents 2 lumbar paraganglioma cases and focuses on nuances to provide ideas for radiological differential diagnosis. [ABSTRACT FROM AUTHOR]

The increasing frequency of obesity is important because of its accompanying related health problems. The effects of obesity on peripheral nerves have not been elucidated. We investigated the effects of obesity on sciatic nerve regeneration using electrophysiology, stereology, immunohistochemistry, histopathology and functional tests. We used control, obese, control injured and obese injured groups of rats. Electrophysiological results showed that nerve conduction velocity and EMG were same in the experimental groups, but the amplitude of the compound action potential of the control group was significantly higher than that of the obese group. Examination of the nerves showed that the control and obese groups had both larger axon diameters and thicker myelin sheaths. The number of myelinated axons was decreased in both of the injured groups. Axon diameters and myelin sheath thicknesses of the control injured group were significantly greater those of the obese injured group. There were no significant differences in functional tests among the groups. Although growth associated protein 43 immunostaining in the control injured group was significantly greater than that of the obese injured group, no significant difference was observed between the control and obese groups. There was no significant difference in immunohistochemical staining for transforming growth factor beta 3 between the control injured and obese injured groups. Our results suggest that obesity may affect peripheral nerve regeneration negatively after crush injury. [ABSTRACT FROM AUTHOR]

Introduction: The aim of the present study was to investigate the reference intervals for thyroid stimulating hormone (TSH) in healthy individuals with normal levels of serum free thyroxine (fT4) and without sonographic pathologies, and determine the effects of age, gender, and residence on the TSH reference intervals. Subjects and methods: This research was a population-based study conducted in 70 regions. The random sampling method was used to select the 1095 subjects of the study among inhabitants aged 18 and above. Patients who had a previous history of thyroid disease and had been taking medication were excluded from the study as this may have affected their fT4 or TSH levels. In addition, subjects who had serum fT4 without a reference range and abnormal ultrasonography findings were also excluded. A total of 408 subjects were used for establishing the reference intervals for TSH. Results: The data for TSH in the study group were not normally distributed according to the Kolmogorov-Smirnov index. The geometric mean was 1.62 mIU/L, the median was 1.40 mIU/L, and the 95% reference intervals were 0.38-4.22 mIU/L. The median TSH level was higher in females compared to males ( p < 0.05). In the female subjects 2.5th percentile of TSH was lower and 97.5th percentile was higher than those of males. The reference intervals of TSH were of lower values in subjects over 50 years old ( p < 0.001). Discussion: Studies suggest that determination of the TSH reference intervals may differ due to environmental influences or due to age, gender, and race. It is suggested that the lower limit of normal TSH for the adult Turkish population would be 0.38 mIU/L and the upper limit similar to the traditional value of 4.2 mIU/L. If each clinician uses their population-specific reference interval for TSH, thyroid function abnormalities can be accurately estimated. [ABSTRACT FROM AUTHOR]

Objective: Topical cytidine-59-diphosphocholine (CDP-choline) improves functional recovery and promotes nerve regeneration in sciatic nerve injury in rats. The aims of this study were to test whether systemic treatment with CDP-choline was effective in improving the recovery of injured sciatic nerve, and to determine whether the cytidine and/or choline moieties of CDP-choline contribute to its beneficial actions. Methods: Seventy Sprague-Dawley rats underwent a surgical procedure that involved transectioning and immediate surgical repairing of the right sciatic nerve. Rats were assigned to one of five groups and administered intraperitoneally 1 ml/kg of saline (control) or saline containing 600 mmol/kg of each of CDP- choline, cytidine, choline, or cytidinezcholine. Results: Recovery in sciatic function index score was greater in rats treated with CDP-choline, choline, or cytidinezcholine at 8 and 12 weeks after the interventions. Peripheral nerve regeneration evaluated by electromyography at 12 weeks was also greater in rats receiving CDP-choline (228% of control), choline (168% of control), or cytidinezcholine (221% of control). Axon counts and axon density increased significantly following CDP-choline, choline, or cytidinezcholine, respectively. Treatment with equivalent dose of cytidine failed to affect sciatic function index, electromyography, and axon counts. Treatment with CDP-choline, but not its metabolites improved nerve adherence and separability score. Conclusion: These data show that intraperitoneal CDP-choline, as well as the combination of its metabolites, cytidinezcholine, improves functional recovery and promotes regeneration of injured sciatic nerves in rats. CDP-choline also improves nerve adherence and separability. [ABSTRACT FROM AUTHOR]