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The chemical investigation of Chromolaena palmaris (Sch.Bip. ex Baker) R.M. King & H. Rob. expands the phytochemical composition knowledge of Chromolaena genus, since this is the first chemical investigation of this species. Twenty-five compounds were identified, including a phytoprostane, 17 flavonoids, 6 phenolic acids, and a caffeoyl-glucoside derivative obtained by classical chromatography and UHPLC-HRMS/MS analysis. Moreover, anti-Mycobacterium tuberculosis and antiproliferative activities of C. palmaris were evaluated. Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 μg mL−1. Furthermore, compounds 1 and 2 exhibited antimicrobial activity against Mycobacterium tuberculosis with MIC of 62.5 and 15.6 μg mL−1, respectively. [ABSTRACT FROM AUTHOR]

Chemical investigation of Lessingianthus brevifolius (Less.) H.Rob. aerial parts resulted in the isolation of the hirsutinolide-type sesquiterpene lactones piptocarphol, spicatolide D, piptocarphin D and 8α-acetoxy-10α-hydroxy-13-O-methylhirsutinolide, and also of a cadinanolide identified as 13-O-methylvernojalcanolide 8-O-acetate. Flavonoids, triterpenes and chlorogenic acids were also isolated. In addition, a dereplication study was carried out using UHPLC-HRMS and molecular networking, resulting in the identification of fifteen known compounds, being two sesquiterpene lactones and thirteen flavonoids. Some of the compounds are being described for the first time in L. brevifolius, and also in the Lessingianthus genus. [ABSTRACT FROM AUTHOR]

Background: SARS-CoV-2 quickly spreads in the worldwide population, imposing social restrictions to control the infection, being the massive testing another essential strategy to break the chain of transmission. Aim: To compare the performance of at-home self-collected samples – saliva and combined nasal-oropharyngeal swabs (NOP) – for SARS-CoV-2 detection in a telemedicine platform for COVID-19 surveillance. Material and methods: We analyzed 201 patients who met the criteria of suspected COVID-19. NOP sampling was combined (nostrils and oropharynx) and saliva collected using a cotton pad device. Detection of SARS-COV-2 was performed by using the Altona RealStar® SARS-CoV-2 RT-PCR Kit 1.0. Results: There was an overall significant agreement (κ coefficient value of 0.58) between saliva and NOP. Considering results in either sample, 70 patients positive for SARS-CoV-2 were identified, with 52/70 being positive in NOP and 55/70 in saliva. This corresponds to sensitivities of 74.2% (95% CI; 63.7% to 83.1%) for NOP and 78.6% (95% CI; 67.6% to 86.6%) for saliva. Conclusion: Our data show the feasibility of using at-home self-collected samples (especially saliva), as an adequate alternative for SARS-CoV-2 detection. This new approach of testing can be useful to develop strategies for COVID-19 surveillance and for guiding public health decisions. [ABSTRACT FROM AUTHOR]

Adolescent survivors of pediatric brain tumor (PBT) are a sparsely studied subset of childhood cancer survivors. Sustaining a PBT may complicate the development of executive functions (EFs), which play a vital role in long-term psychosocial adjustment. In this study, 48 adolescent survivors and their parents completed questionnaires assessing EF, psychological symptoms, fatigue, and adaptive functioning, and 26 survivors underwent neuropsychological assessment. Survivors reported significantly more problems with adaptive functioning than a healthy control group, and this was most strongly associated to executive dysfunction, compared to psychological symptoms and fatigue. The findings have important implications for long-term follow-ups. [ABSTRACT FROM AUTHOR]

Objective: Emerging evidence suggests that moral processes are disrupted by traumatic brain injury (TBI). The objective of this study was to explore moral reasoning (MR) and decision-making in adolescents with TBI, and to examine potential associations with global manifestations of social competence. Design: This retrospective, cross-sectional research design compared MR and decision-making in adolescents with mild TBI (n = 20), moderate-severe TBI (n = 23) and typically developing controls (n = 93). Methods: Participants completed a visual task of socio-moral reasoning (SoMoral) and the Index of Empathy for Children and Adolescents. Their parents completed questionnaires documenting their child's behavior (Child Behavior Checklist) and adaptive functioning (Adaptive Behavior Assessment System-Second Edition). Main results: Adolescents with both mild and moderate-severe TBI displayed more immature MR than typically developing peers. Participants with TBI also provided fewer socially adapted decisions. Closer inspection revealed that this difference was apparent only in the mild TBI group. No significant group differences were observed for empathy, behavior or adaptive skills. Conclusions: Sustaining TBI appears to affect adolescents' ability to provide mature moral justifications when faced with moral dilemmas representative of everyday social conflicts. These difficulties do not appear to be associated with behavior problems, reduced empathy, or adaptive functioning. [ABSTRACT FROM AUTHOR]

Maltreatment of children is a chronic community problem that increases the risk of future aggression. Despite several decades of research highlighting this relationship, few studies have explored the potential neuropsychological deficits that are likely to mediate it. This exploratory study aimed to examine how child maltreatment may be associated with aggression via impairment in the developing prefrontal-limbic-autonomic pathways that are implicated in neuropsychological models of aggression. Furthermore, it aimed to investigate the relationship between child maltreatment and both reactive and proactive aggression subtypes. To investigate this non-invasively in an at-risk population, children with a documented protective care history (n = 20) and a community control group (n = 30), aged between 6 and 12 years, were compared on measures of cardiovascular functioning, affect regulation and cognitive functioning aligned with this neuropsychological model. Whilst no group differences were found on cardiovascular functioning (i.e., resting heart rate, heart rate reactivity, heart rate variability), the protective care group performed significantly worse on measures of affect regulation and cognitive functioning (i.e., global intelligence, executive functioning, smell identification and social cognition). The relationship between child maltreatment and aggression was mediated by executive dysfunction and affect dysregulation but not global IQ, social cognition or olfactory identification. The results suggest that interventions targeting aggression in maltreated children will benefit from clinical assessment and psychological strategies that address the executive dysfunction and affect dysregulation that has been associated with this clinical outcome. [ABSTRACT FROM PUBLISHER]

Trichogenes longipinnisBritski & Ortega is a narrowly distributed endemic and phenotypically variable catfish from the coastal basins of the Serra do Mar range in southeast Brazil. We examined patterns of mtDNA variation of this species in coastal basins of the Serra do Mar to determine the influences of past climatic and geomorphological processes in connection with the currently isolated basins. Allozyme data were also used to test the hypothesis that the different spotting patterns in the different areas could be the result of cryptic speciation. Regardless of body pigmentation,T. longipinnisspecimens from across the basins were found to belong to a single species, but the populations were structured in accordance with the current hydrological watersheds, in four management units across the three distinct basins of its geographic distribution. Thus, the current genetic distribution may be best explained by both marine regressions and orogeny. Based on the low levels of genetic variation and high population structure observed, we suggest thatT. longipinnisshould be classified as “vulnerable” in the Brazilian red list of threatened fauna. Furthermore, we propose that the headwaters of the Parati-Mirim River basin should be incorporated as an extension of the Bocaina National Park to protect its genetically differentiated lineages. [ABSTRACT FROM PUBLISHER]

We review the main biogeographic and phylogenetic hypotheses about the origin and distribution of the endemic birds from Brazilian mountaintops, a heterogeneous group composed of hummingbirds and passerines living in high-altitude open habitats ofcampos rupestres,campos de altitudeandcampos sulinosfrom southern to north-eastern Brazilian mountaintops (Espinhaço Range, Serra do Mar, Serra da Mantiqueira and Serra Geral). Some authors consider that these birds are probably closely related to other species distributed in cooler areas of South America. We used ranges of these birds, spatial pattern and discontinuities in the distribution of phytophysiognomies to determine potential geographic barriers to dispersal and centres of origin and speciation. We reanalysed biogeographical hypotheses regarding the evolution of the endemic birds from Brazilian mountaintops and their habitats in the light of recent phylogenetic reconstructions that included some of these species. The evolutionary histories of the speciesAugastes scutatus,Augastes lumachella,Formicivora grantsaui,Polystictus superciliarisandEmbernagra longicaudaare difficult to assess due to lack of phylogenies that establish their systematic position. ForAsthenes luizae,Asthenes moreirae,Cinclodes pabstiandC. espinhacensis, the phylogenies estimate also their lineage divergence times, which allows for inferences concerning connections between the biota of eastern Brazil, southern South America and the Andean mountains. We also identified 26 lowland regions between the mountains that were potentially barriers to dispersal. Phylogenetic relationships strongly highlight the importance of connecting paths and speciation through the south, especially in the cooler areas in South America. These patterns show that eastern Brazil, southern South America and the central and northern Andes are four important centres of origin and radiation for the endemic birds from the eastern Brazilian mountains. [ABSTRACT FROM PUBLISHER]

Objective: This study investigated the long-term psychosocial outcome and quality-of-life (QoL) of 15-18 year olds, sustaining childhood traumatic brain injury (TBI) between birth and 5 years. Method: Thirty-three participants (17 TBI parent-proxies, 16 control parent-proxies) were involved in the present study which compared parent-ratings for the TBI group and healthy controls on the Sydney Psychosocial Reintegration Scale-Child form (SPRS-C) and the Paediatric Quality of Life Inventory (PedsQL). Results: Despite comparable overall psychosocial reintegration scores, parents reported that their teens with TBI were more likely to experience poor QoL compared to controls. On further analysis, some aspects of psychosocial outcome appear to be compromised following childhood TBI. Conclusions: Interventions targeting childhood TBI must consider QoL in addition to symptom reduction and be extended throughout adolescence. The limitations of the sample size are cause for concern; however, preliminary results do validate the need for future research efforts. [ABSTRACT FROM AUTHOR]

Primary objective: Traumatic brain injury (TBI) sustained during childhood can affect a number of socio-cognitive skills; however, little attention has focused on the integrity of moral reasoning in the assessment of post-TBI social sequelae and the role of empathy and intelligence on moral maturity. Research design: In a quasi-experimental, cross-sectional research design, moral reasoning maturity and empathy in adolescents with mild-to-severe TBI ( n = 25) were compared to typically-developing peers ( n = 66). Methods and procedures: Participants were administered the So-Moral and So-Mature, tasks of socio-moral reasoning and maturity, the Index of Empathy for Children and Adolescents, the Wechsler Abbreviated Scale of Intelligence and a demographic questionnaire. Main outcomes and results: Participants with TBI had significantly lower levels of moral reasoning maturity. Further, adolescents with moderate-to-severe TBI had lower levels of empathy. Empathy correlated positively with moral reasoning abilities and, together with intellectual function, predicted a small, but significant proportion of moral reasoning outcome. Conclusions: Youth who sustained TBI during childhood have poorer moral reasoning abilities than their non-injured peers, potentially placing them at risk for poor social decision-making and socially maladaptive behaviour. This can have a significant impact on long-term social functioning. [ABSTRACT FROM AUTHOR]

This study examined the ability of children with hemiplegia to perform motor imagery of their unaffected hand. Children (8-12 years) formed three groups-R-HEMI: right-sided hemiplegia, n = 21; L-HEMI: left-sided hemiplegia, n = 19; and Comparisons, n = 21. We expected no group differences on a simple imagined grasping task, but the hemiplegia groups to perform atypically on an imagined pointing task. Results showed no group differences on the grasping task, while only the L-HEMI group performed atypically on the pointing task- the functional level of the children played a likely role in this finding. Children with hemiplegia can engage in motor imagery, although task complexity and functional level may have an impact. [ABSTRACT FROM AUTHOR]

Childhood stroke is increasingly recognized as a major cause of childhood morbidity and mortality; however, limited information exists regarding neurobehavioral sequelae. Executive function (EF), important for problem solving, reasoning, social awareness, and adaptive behavior, may be particularly vulnerable to early brain lesions such as stroke, due to its protracted development. This study investigated: (i) the impact of childhood stroke on EF; and (ii) the impact of lesion size on EF outcome. Twenty-eight children diagnosed with stroke at least 12 months prior to assessment were recruited. Neurobehavioral assessment focused on cognitive and behavioral aspects of EF. Lesion volume was determined from standard ratings of brain pathology based on magnetic resonance imaging (MRI) scans. Deficits in cognitive aspects of EF were detected in attentional control, cognitive flexibility and information processing. Difficulties in behavioral aspects of EF were most striking, with problems identified across a wide range of behaviors. Lesion size impacted on EF, with large lesions (greater than 25% of brain volume) proving the most detrimental. [ABSTRACT FROM AUTHOR]

The article discusses papers which focus on the relations between genetics and religion. It says that the article titled "Sequencing the human genome: Gateway to personalized medicine or the new eugenics," by William Oetting, offers advanced approaches to personalized medicine. Meanwhile, the study "The behavioral genetics of religiousness," by Laura B. Koenig and Matt McGue, examines whether the individual differences on religious behavior depend on genetics.

Patients in cardiac rehabilitation are typically advised to complete a period of supervised endurance training before beginning resistance training. In this study, however, we compared the peak rate-pressure product (RPP, a calculated indicator of myocardial work) of patients during two types of exercise-treadmill walking and chest press-from workout session 1 through completion of cardiac rehabilitation. Twenty-one patients (4 women and 17 men, aged 35 to 70 years) were enrolled in the study; they were referred for cardiac rehabilitation after myocardial infarction, percutaneous coronary intervention, or both. The participants did treadmill walking and chest press exercises during each workout session. Peak values for heart rate (HR) and systolic blood pressure (SBP) were recorded, and the peak RPP was calculated (peak HR x peak SBP). Paired t tests were used to compare the data collected during the two types of exercise across 19 workout sessions. The mean peak values for HR, SBP, and RPP were lower during resistance training than during endurance training; the differences were statistically significant (P < 0.05), with only one exception (the SBP for session 1). Across all 19 workout sessions, the participants performed more myocardial work, as indicated by the peak RPP, during treadmill walking than during the chest press. [ABSTRACT FROM AUTHOR]

Our understanding of the neuropsychological effects of encephalitis has largely come from studies in which the level of premorbid functioning is estimated. Moreover, data on the neuropsychological effects of encephalitogenic pathogens other than the herpes simplex virus (HSV) are scant. We present the case of a 7-year-old girl who had intellectual and language assessment seven months prior to the onset of non-HSV encephalitis (possible aetiology: Mycoplasma pneumoniae), and again post-encephalitis. MRI post-illness demonstrated basal frontal, temporal and (limited) parietal damage. Details of speech, psychological and neuropsychological assessments were also documented. Pervasive changes were apparent in the domains of personality, behaviour, emotionality, attention, executive function, speech, language and memory. The patient's profile appears to differ most from that seen following typical HSV encephalitis with respect to marked executive and attentional difficulties. Her deficits appear to reflect both her acute basal brain injury and more diffuse insult, probably caused by postinfectious encephalitis. [ABSTRACT FROM AUTHOR]

This study investigated working memory (WM) in children with Attention-Deficit/Hyperactivity Disorder (ADHD) using a task switching paradigm with Stroop color-word stimuli which required participants to switch from color-naming to word-reading. High and low WM load conditions were compared by manipulation of task reminders as a tempo cue. The sample comprised 83 children with ADHD and 29 normal children comparable in age (aged 7 to 13). Within the ADHD group, participants were divided according to the presence or absence of Learning Disability (LD). Results indicated that children with ADHD had slower response times and less accurate responses in general, however, the ADHD groups were not consistently slower in the high WM load condition. Instead, an impairment in adjusting response speed to cope with higher task demands (i.e., high WM load condition) was found. These results do not support the previously documented association between ADHD and a primary deficit in WM for task switching. However, children with ADHD do demonstrate a specific difficulty in slowing down for a demanding task. Present findings suggest that earlier proposals of under-arousal and poor state regulation in ADHD deserve renewed attention. [ABSTRACT FROM AUTHOR]

Due to the mechanisms involved in traumatic brain injury (TBI), the frontal lobes are often impacted. As the frontal regions of the brain are believed to subsume executive functioning, then it follows that post-TBI deficits may be seen in this domain. Executive functioning broadly refers to a set of inter-related skills necessary to maintain an appropriate problem-solving set for the attainment of a future goal and may include areas such as attentional control, planning, problem-solving, cognitive flexibility, abstraction and information processing. The literature available on interventions for executive difficulties following TBI is minimal, with that focused on the paediatric population even more limited. From the few evaluation studies available, results tend to suggest that specific types of intervention lead to positive outcomes. However, as the interventions are few and often based on case studies, there is much need for more evaluation studies to be conducted. [ABSTRACT FROM AUTHOR]

Primary objective : Attentional deficits are common following TBI in adults. This study examined whether these skills are also vulnerable following early childhood injury, when such skills are rapidly developing. Research design : This study investigated attention 30 months post-TBI in pre-schoolers ( n ?=?56) and age-matched controls ( n ?=?26). TBI children were divided into mild, moderate and severe injury groups. Methods and procedure : Pre-injury data were collected at time of injury. Assessment of attention included the Continuous Performance Test, Wechsler Intelligence Scale and Personality Inventory for Children. Main outcomes and results : Severe TBI was associated with reduced accuracy and slowed processing, particularly on complex motor responses. Sustained attention was more intact. Parental reports indicate internalized behavioural problems and somatic complaints. Conclusions : Young children with severe TBI are at risk for severe, persisting attentional impairments. Children with mild and moderate TBI show better outcome, with pre-injury behaviour and age also predictive of attentional skills at 30 months post-injury. [ABSTRACT FROM AUTHOR]

Primary objective : Disruptions to executive function (EF) may occur as a result of traumatic brain injury (TBI), in the context of direct damage to frontal regions or in association with disruption of connections between these areas and other brain regions. Little investigation of EF has occurred following TBI during childhood and there is little evidence of possible recovery trajectories in the years post-injury. The present study aimed to (i) examine whether a dose-response relationship exists between injury severity and EF; (ii) document recovery of EF in the 2 years post-injury and (iii) determine any additional predictors of outcome in the domain of EF. Research design : The study employed a prospective, longitudinal design, with participants recruited at time of injury and followed over a 2-year period. Methods and procedures : The study examined EF in a group of 69 children who had sustained a mild, moderate or severe TBI. Four components of EF were assessed: (i) attentional control; (ii) planning, goal setting and problem solving; (iii) cognitive flexibility; and (iv) abstract reasoning. Outcomes and results : Results showed that, while children with severe TBI performed most poorly during the acute stage post-injury, they exhibited greatest recovery of EF over a 24-month period. Regardless, functional deficits remained most severe for this group 2 years post-injury. Results demonstrated the multi-dimensional nature of EF and the differential recovery of skills, following childhood TBI. Pre-injury ability and age at injury were identified as significant predictors of EF and functional skills. Conclusions : Children sustaining severe TBI at a young age are particularly vulnerable to impairments in EF. While these difficulties do show some recovery with time since injury, long-term deficits remain and may impact on ongoing development. [ABSTRACT FROM AUTHOR]

Detailed study of the very earliest phases of Alzheimer's disease (AD) is seldom possible, especially those changes preceding the development of mild cognitive impairment (MCI), which may occur years before diagnosis. Knowledge of imaging and neuropsychological features of these early stages would add insight into this poorly understood phase of the disease. We present data from a subject who entered a longitudinal study of individuals at risk of familial Alzheimer's disease (FAD), as a healthy volunteer with no memory complaints, undergoing 12 assessments between 1992 and 2003. Longitudinal MRI, neuropsychological and clinical data are presented over the decade preceding this man's diagnosis, through the asymptomatic and prodromal preludes to his presentation with MCI and on to eventual conversion to AD. [ABSTRACT FROM AUTHOR]

Purpose: To test whether exposure to simulated GSM mobile phone signals (915 MHz, 2 W kg[sup -1]) influences the concentration of calcium or calcium signalling patterns in a human lymphocyte cell line. Materials and methods: The radiofrequency (RF) energy was delivered via a coaxial applicator to a perfused chamber where cells adherent to a thin glass coverslip were imaged by laser scanning confocal microscopy. Cell calcium concentration, estimated from Fluo-3 fluorescence, was monitored over two 10-min periods; control followed by exposed/sham, with exposure status assigned in a blind and randomized fashion. Both continuous wave (CW) and pulsed wave (PW) RF (on both phytohaemagglutanin-activated and unactivated cells) were studied (with an equal number of sham exposures) on 100 cells per category (total 800 cells). Results: No significant changes were noted for the following: regression slope of calcium fluorescence; mean calcium concentration; number of calcium 'spikes' in each 10 min; or mean height of these 'spikes'. The average frequency from Fourier spectra of these periods showed significant alteration in one category only: PW exposure of activated cells. Conclusions: There is no clear indication that RF emissions from mobile phones are associated with any changes in calcium levels or calcium signalling in lymphocytes. [ABSTRACT FROM AUTHOR]

Academic success in the classroom is often dependent upon a child's ability in the areas of literacy, such as reading and spelling, and arithmetic. Following traumatic brain injury these skills are often compromised. The present study examined the recovery of educational skills (reading accuracy, reading comprehension, spelling and arithmetic) over 24 months post-injury, in a group of children who had sustained a mild, moderate or severe TBI. Results showed that the severe TBI group exhibited greater deficits on reading comprehension and arithmetic, while the moderate and severe TBI groups performed similarly in the areas of reading accuracy and spelling. Future research is required to further investigate predictors of educational outcome post-TBI. [ABSTRACT FROM AUTHOR]

This study investigated attentional impairments and recovery in pre-school children following traumatic brain injury (TBI). Children aged between 3-8 years were assigned to two groups on the basis of severity of injury: (i) mild TBI and (ii) severe TBI. Children were evaluated at the acute stage postinjury (0-3 months) and again at 6 months on a range of standardized intellectual and attention measures. In addition, a specifically developed behavioural attention measure was employed. Results revealed a tendency for children with severe injuries to exhibit greater attentional impairments in the acute phase post-injury. In addition, children who sustained a severe TBI demonstrated significant recovery in attentional functioning over time. Results indicated differential recovery rates for separate components of attention. Both groups demonstrated a trend towards recovery of arousal and motivation over time, while focused attention, impulsivity and hyperactivity remained stable. [ABSTRACT FROM AUTHOR]

Language skills undergo rapid development during the early childhood years, so that by the time children start school they are competent communicators with well established syntactic, semantic and pragmatic abilities for their age. Little is known about the effects of traumatic brain injury (TBI) on the acquisition of these language skills during the early childhood years. This study used a prospective, cross-sectional design to compare the language abilities of young children following their head injury. Fifteen brain injured children, aged between 4-6 years, were divided into three injury groups depending on severity of injury, i.e. mild, moderate and severe, and compared with a matched community control group. They were assessed within 3 months of sustaining their injury on a range of expressive and receptive language tests, and free speech conversation samples, which were analysed pragmatically and syntactically. Results indicated that the severe group performed most poorly on language tasks. It is suggested that linguistic evaluation is an important component of follow up at least for the severe head injured population. [ABSTRACT FROM AUTHOR]

This paper presents an overview of NIOSH research aimed at characterizing and identifying intervention strategies for reducing musculoskeletal injuries during manual handling activities. Surveillance and evaluative research projects are reviewed. Future research directions of the Institute are also discussed. [ABSTRACT FROM PUBLISHER]

Neuropsychological and psychosocial assessment of 58 Victorian and South Australian school-aged children who sustained a closed head injury was carried out immediately postinjury and at 6 months follow-up. for those children whose head injury was defined as mild (length of coma less than 1 hour) outcome on all variables was good at both time points. Children with moderate to severe injury (length of coma greater than 1 hour) had lower WISC-R IQ scores at both time points and were particularly poor on reading and spelling measures. There was no improvement over time on the academic measures. Family and parental functioning was in the normative range and, although some children showed a clinical level of behaviour problems, there was no consistency in their clinical status over time nor across parent and teacher informants. Our results suggest that there are no particular concerns for the long-term outcome of mildly head-injured children but that cognitive and school learning problems for moderate to severely head-injured children puts them at continuing risk. [ABSTRACT FROM AUTHOR]

A statistical model is presented for describing the distribution of book uses in a research library. This model is used to attack the problem of book storage in a research library. A rule which says that a book goes to the storage collection if it is not used for k consecutive years after its acquisition in the library is studied. A similar rule for transferring active books from the storage to the active collection is also examined. Examples are provided to illustrate some of the results. [ABSTRACT FROM AUTHOR]

Children with focal frontal lobe pathology were administered a battery of executive function measures to examine the relationship between epilepsy and outcome. The sample comprised 39 children with focal frontal pathology, of which 20 children had epilepsy. There was a negative association between age at injury and presence of epilepsy with a higher rate of epilepsy found in children with developmental lesions or injuries acquired prior to 7 years of age. Although all children with focal frontal pathology experienced problems on measures of executive function compared with controls, greatest problems were seen in those children who also had epilepsy. Results suggest a dual hazard effect, with earlier injuries associated with an increased risk of epilepsy and poorer executive function development. [ABSTRACT FROM AUTHOR]

Spatial memory continues to be a controversial area within neuropsychology, both in terms of assessment techniques as well as the broader issue of cerebral localisation. Whilst it is generally assumed that spatial memory is a function of the right temporal lobe, this relationship is only inconsistently supported in adults and largely unexplored in children. This paper addresses this issue in a sample of children with unilateral, circumscribed temporal lobe lesions (n = 20 left, n = 20 right). A range of spatial memory measures were administered including standard measures, such as the Rey Complex Figure, together with a novel experimental task, the Nine Box Maze Test. The results do not support a pattern of material specific spatial memory impairment, but rather highlight the influence of developmental and seizure variables on memory function in general. These results are discussed in terms of the impact on presurgical evaluation, as well as the applicability of adult models of memory to paediatric settings. [ABSTRACT FROM AUTHOR]

Paediatric epilepsy is a challenging area of clinical practice, as relatively little research has investigated the interplay between developmental, seizure and cognitive variables. The papers within this symposium address these issues in children with hypothalamic haematomas and complex partial seizures of variable origin. Whilst the underlying seizure focus differs in each of these groups, there is a common finding that developmental and seizure variables do strongly influence cognitive function. Collectively these papers highlight the need to develop models of epilepsy specifically for children, which emphasise the multi-determinants of cognitive function. [ABSTRACT FROM AUTHOR]

This paper is an epidemiological comparison of the prevalence of substance use (tobacco, alcohol and illicit drugs) and sexual behaviour among adolescents diagnosed with cancer during childhood and adolescents with no cancer history. One-hundred and fifty-three adolescent survivors diagnosed in childhood were compared with two healthy adolescent populations. The results revealed a relatively large proportion of survivors were engaging in risky health practices, with older survivors at greater risk of participation than younger survivors. Current alcohol use was the most prevalent health risk behaviour reported by the total cancer survivor population and by both age groups (i.e., younger and older survivors). Cancer status appears to have had a significant impact upon the use of many health compromising behaviours. Young survivors were at a reduced risk of current alcohol use, binge drinking; current tobacco use, cannabis use, other illicit drug use, sexual intercourse and unprotected sex and an elevated risk of using pain relievers. Older survivors were at a lower risk of current tobacco use, cannabis use and illicit drug use and an increased risk of current alcohol use. Despite survivors being at a reduced risk of engaging in many health compromising behaviours compared with healthy adolescents, it appears regardless of the health consequences many survivors were actively participating in health risk behaviours. The findings indicate that while still engaging in health compromising behaviours to a concerning extent, adolescent survivors may be more vigilant in their use of specific substances compared with healthy adolescents. The Health Belief Model is one theoretical framework that may help in explaining these differences. [ABSTRACT FROM AUTHOR]