1. RUNX1 ABERRATIONS IN ETV6/RUNX1-POSITIVE AND ETV6/RUNX1-NEGATIVE PATIENTS: Its Hemato-Pathological and Prognostic Significance in a Large Cohort (619 Cases) of ALL.
- Author
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Pais, Anurita Peter, Amare Kadam, Pratibha S., Raje, Gauri Chandrakant, Banavali, Shripad, Parikh, Purvish, Kurkure, Purna, Arora, Brijesh, Gujral, Sumit, Kumar, S. Ashok, and Badrinath, Y.
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LYMPHOBLASTIC leukemia in children , *COHORT analysis , *B cells , *PHENOTYPES , *PEDIATRIC research - Abstract
A large-cohort study (619) of acute lymphoblastic leukemia (ALL) revealed an ETV6/RUNX1 (previously known as TEL/AML1) incidence of 18% in pediatric B-cell precussor ALL, indicating no geographical heterogeinity. Association of CD34-negative phenotype, peak incidence in the 3- to 7-year age group, and a comparatively low frequency of ETV6 homologue loss in ETV6/RUNX1-positive cases were distinct findings in this series. Additional genetic changes, such as ETV6 loss, extra RUNX1, ETV6/RUNX1 duplication, and MLL aberrations in the ETV6/RUNX1-positive group, supported the hypothesis of the ETV6/RUNX1 leukemogenic model that these secondary changes are necessary for leukemogenesis rather than progression of disease. This study disclosed RUNX1 alterations in the ETV6/RUNX1-negative group of BCP-ALL that encourages the investigation of RUNX1 at a large scale with longer follow-up, which will focus on the prognostic importance and the underlying biology of disease. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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