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To investigate the structure-activity relationship of L-glutamine and L-asparagine Schiff base copper complexes in applications, L-glutamine and L-asparagine Schiff bases (GV and AV) and their copper complexes [Cu3(GV)2(CH3COO)2(H2O)] · 2H2O (GVC) and [CuAV(H2O)3] (AVC) have been synthesized and characterized by molar conductance, elemental analysis, UV-Vis, IR, 1H-NMR, and TG-DTG. We examined the geometries of GV, AV, GVC, and AVC through Hartree-Fock method and electronic absorption spectra. We also tested their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis bacteria and antiproliferation activity on human breast cancer MDA-MB-231 cells. The side chain difference between L-glutamine and L-asparagine results in different geometry of GV and AV, which leads to different geometry of GVC and AVC. GVC, a trinuclear Cu(II) complex, shows the highest antibacterial activity and the highest growth inhibition activity on MDA-MB-231 cells. Our results suggest that GVC has potential as an antibacterial and anticancer agent. [ABSTRACT FROM AUTHOR]

A new Schiff base ligand (KH2L) was synthesized using potassium salt of glycine and 2,4-dihydroxybenzaldehyde. A binuclear complex of this ligand [Cu2 (HL)2] 2H2O was synthesized and characterized by elemental analyses, IR, UV, TG-DTG, and molar conductance. The fundamental electrochemical characteristics of the Cu(II) complex have been studied, and the interaction of the copper complex and DNA was also studied by cyclic voltammetry and fluorescence spectra. The results of the cyclic voltammetry showed that the Cu(II) complex had an oxidation peak with the oxidation potential at -0.345 V. After the DNA was added, the peak current declined with the peak potential shifting positively. This suggested that the complex combined with DNA in the form of intercalative binding, which was also proved by the fluorescence analysis. [ABSTRACT FROM AUTHOR]