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The antioxidant and antidiabetic activity of methanol leaves extract (CPMLE) and ethyl acetate fraction (CPEALF) of lemon hill (Citrus pseudolimon) was examined on key enzymes (α-glucosidase and α-amylase) in type-2 diabetes. In-vivo antidiabetic activity was evaluated in streptozotocin (STZ)-induced diabetic rats against CPMLE and CPEALF. Methanolic extract of the plant was effective against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (IC50 = 313.20 µg mL−1), reducing power (IC50 = 366.69 µg mL−1), and H2O2 scavenging (IC50 = 498.26 µg mL−1) and phosphomolybdate radical scavenging activity (IC50 = 508.02 µg mL−1). Ethyl acetate fraction demonstrated DPPH radical scavenging (IC50 = 259.33 µg mL−1), reducing power (IC50 = 268.91 µg mL−1), and H2O2 scavenging (IC50 = 476.39 µg mL−1) and phosphomolybdate radical scavenging activity (IC50 = 278.60 µg mL−1). C. pseudolimon methanol extract had inhibitory activity against α-glucosidase (IC50 = 350.09 µg mL−1) and α-amylase (IC50 = 291.17 µg mL−1) enzymes. Oral administration of CPMLE and CPEALF reduced elevated fasting blood glucose, lipid levels, and oxidative stress along with Hb1AC level. [ABSTRACT FROM AUTHOR]

The antihyperlipidemic effect of ethanolic extract of seeds of Solanum nigrum L. and its chloroform fraction was explored in Triton induced hyperlipidemic rats. Bioactivity guided fractionation followed by flash chromatography of the most active fraction resulted in the isolation of Stigmast-5, 22-dien-3β-ol. After 24 h of i.p. injection of Triton administration at 400 mg. kg-1 b.w., the extract and fraction were administered orally at doses of 200 and 400 mg. kg-1 b.w. Serum samples analyzed showed a dose dependent inhibition of the total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and increased high density lipoprotein (HDL) level. [ABSTRACT FROM PUBLISHER]

The methanolic extract of Trianthema portulacastrum (Aizoaceae) was evaluated for antihyperlipidemic and antioxidant activity in high-fat-diet-induced hyperlipidemic rats. It was found that the extract caused a significant reduction in the lipid levels in hyperlipidemic rats and was comparable with the standard anti-hyperlipidemic drug atorvastatin. It was also found that the plant extract increased the liver antioxidant enzyme (catalase, superoxide dismutase, glutathione) levels while reducing the lipid peroxide (malondialdehyde) levels. [ABSTRACT FROM AUTHOR]