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Your search keyword '"Guo, Xu"' showing total 5 results
5 results on '"Guo, Xu"'

1. Two new degradative cassane-type diterpenes isolated from Caesalpinia minax.

Author

Sun, Zhao-Cui, Ma, Guo-Xu, Yuan, Jing-Quan, Wei, Hua, Wu, Hai-Feng, Sun, Zhong-Hao, Wang, Guo-Hong, Yang, Jun-Shan, and Xu, Xu-Dong

Subjects
*CHROMATOGRAPHIC analysis, *INFRARED spectroscopy, *MASS spectrometry, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *PHARMACEUTICAL chemistry, *RESEARCH funding, *TERPENES, *PLANT extracts
Abstract

Cassane-type diterpenes are main bioactive constituents of Caesalpinia minax HANCE. As a part of our ongoing chemical investigation of C. minax, two new degradative cassane-type diterpenes, named caesalpins I (1) and J (2), were isolated from the EtOAc extract of the seeds of C. minax. The structures were elucidated by means of spectroscopic analysis. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax.

Author

Ma, Guo-Xu, Xu, Na, Yuan, Jing-Quan, Wei, Hua, Zheng, Qing-Xia, Sun, Zhao-Cui, Yang, Jun-Shan, and Xu, Xu-Dong

Subjects
*BIOLOGICAL assay, *CELL culture, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *PHARMACEUTICAL chemistry, *RESEARCH funding, *TERPENES, *THIN layer chromatography, *PLANT extracts
Abstract

Two new cassane-type diterpenes, neocaesalpin MR (1) and minaxin C (2), were isolated from Caesalpinia minax HANCE. The structures of these compounds were elucidated by means of spectroscopic analysis. Among these isolated compounds, neocaesalpin MR showed mild activities toward HeLa and colon cancer (HCT-8) human cancer cell lines. [ABSTRACT FROM PUBLISHER]

Published
2012
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3. A new steroidal saponin from Polygonatum sibiricum.

Author

Zhang, Hong-Yang, Hu, Wei-Cheng, Ma, Guo-Xu, Zhu, Nai-Liang, Sun, Xiao-Bo, Wu, Hai-Feng, and Xu, Xu-Dong

Subjects
*CELL lines, *COMPARATIVE studies, *HEPATOCELLULAR carcinoma, *LIVER tumors, *MEDICINAL plants, *MOLECULAR structure, *RESEARCH funding, *SPECTRUM analysis, *STEROIDS, *PHYTOCHEMICALS, *PLANT extracts, *CYTOTOXINS
Abstract

A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2-5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3-5 showed significant cytotoxicity against HepG2 cell lines with IC50 values of 14.2, 12.1 and 8.5 μM, respectively. [ABSTRACT FROM AUTHOR]

Published
2018
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4. Cassane-type diterpenes from Caesalpinia minax induce apoptosis in pituitary adenoma: structure–activity relationship, ER stress and Wnt/β-catenin pathways.

Author

Li, Zong-Yang, Li, Qing-Zhong, Ma, Guo-Xu, Chen, Lei, Zhang, Ce, Chen, Bao-dong, Yang, Jun-Shan, and Li, Wei-Ping

Subjects
*ANIMAL experimentation, *ANTINEOPLASTIC agents, *APOPTOSIS, *BIOLOGICAL assay, *CELL culture, *CELL lines, *CELL physiology, *CELLULAR signal transduction, *CYTOSKELETAL proteins, *ENDOPLASMIC reticulum, *FLAVONOIDS, *FLOW cytometry, *LACTATE dehydrogenase, *MICE, *MOLECULAR structure, *PITUITARY tumors, *PROBABILITY theory, *PROTEOLYTIC enzymes, *RESEARCH funding, *STAINS & staining (Microscopy), *STATISTICS, *PHYSIOLOGICAL stress, *T-test (Statistics), *TERPENES, *TOXICITY testing, *WESTERN immunoblotting, *PLANT extracts, *DATA analysis, *WNT proteins, *DESCRIPTIVE statistics, *TEMOZOLOMIDE, *ONE-way analysis of variance
Abstract

Plant-derived natural products have been the highly significant sources of novel antitumor agents. The cassane-type diterpenes of genusCaesalpiniahave been reported to bear antiproliferative activities toward different types of cancer cells. In this study, we evaluated the antineoplasmic activities of 16 natural origin cassane-type diterpenes isolated from the CHCl3extract of the seeds ofC. minaxin pituitary adenomas cells and identified caesalpin G (CAG) showed the strongest cytotoxicity. Moreover, we further investigated the structure–activity relationship and molecular mechanism of these derivatives systematically. The results confirmed the unsaturated lactone-type ring, hydroxyl at C-7, and alkenyl at C-11 or C-14 functionality as critical for anticancer activity in this family of natural products. In addition, the mechanism experiments also demonstrated unfolded protein response and ER stress and Wnt/β-catenin pathway were involved in the CAG-induced apoptosis. [ABSTRACT FROM PUBLISHER]

Published
2017
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5. A new ursane-type triterpene, cymosic acid from Rosa cymosa.

Author

Wu, Xiao-Peng, Zhang, Xiao-Po, Ma, Guo-Xu, Han, Mo, Xu, Mu-Die, Wu, Hai-Feng, Huang, Xiao-Yan, Huang, Zhen, Yang, Jun-Shan, Yuan, Jing-Quan, Xu, Xu-Dong, and Zhong, Xiao-Ming

Subjects
*ANIMAL experimentation, *BIOLOGICAL assay, *CELL culture, *HIGH performance liquid chromatography, *MASS spectrometry, *MICE, *MOLECULAR structure, *NITRIC oxide, *NUCLEAR magnetic resonance spectroscopy, *RESEARCH funding, *TERPENES, *PLANT extracts, *LIPOPOLYSACCHARIDES, *DESCRIPTIVE statistics
Abstract

A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its 1H and 13C NMR, 1H–1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells. [ABSTRACT FROM AUTHOR]

Published
2014
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