1. Platycosides P and Q, two new triterpene saponins from Platycodon grandiflorum.
- Author
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Qiu, Lu, Xiao, Yu, Liu, Yao-Qi, Peng, Lian-xin, Liao, Wan, and Fu, Qiang
- Subjects
ANTI-inflammatory agents ,CELLULAR signal transduction ,ETHANOL ,GLYCOSIDES ,HERBAL medicine ,HIGH performance liquid chromatography ,MACROPHAGES ,CHINESE medicine ,MOLECULAR structure ,MONOSACCHARIDES ,RESEARCH funding ,PLANT roots ,TUMOR necrosis factors ,PLANT extracts ,PHARMACODYNAMICS - Abstract
The EtOH extract of the roots of Platycodon grandiflorum afforded two new triterpene saponins platycoside P (1) and platycoside Q (2). Their structures were elucidated based on spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against LPS-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed inhibitory activity with the inhibition ratios (%) of 38.6 and 44.1 at 50 μM, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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