Search

We propose an adaptive enrichment approach to test an active factor, which is a factor whose effect is non-zero in at least one subpopulation. We implement a two-stage play-the-winner design where all subjects in the second stage are enrolled from the subpopulation that has the highest observed effect in the first stage. We recommend a weighted Fisher's combination of the most powerful test for each stage, respectively: the first stage Hotelling's test and the second stage noncentral chi-square test. The test is further extended to cover binary outcomes and time-to-event outcomes. [ABSTRACT FROM AUTHOR]

Varied findings exist concerning the relationship between global tic severity, impairment, and quality of life for youth with chronic tic disorders (TD). As global tic severity is comprised of multiple dimensions, specific dimensional aspects (e.g., tic severity type, tic number, tic frequency, tic intensity, tic complexity, tic interference) may impact impairment and quality of life by varying degrees. Twenty-four youth with TD completed an assessment of global tic severity, tic-related impairment, and quality of life. Findings suggest that motor tic severity significantly predicted clinician-rated impairment. Tic number, tic complexity, and tic interference significantly predicted parent-rated impairment. No dimensional aspects of tic severity predicted child-rated quality of life. Findings highlight that dimensional aspects of tic severity impact tic-related impairment distinctively. Clinical implications of these results are discussed. [ABSTRACT FROM PUBLISHER]