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Your search keyword '"Konishi, Noboru"' showing total 1 results
Start Over Author "Konishi, Noboru" Topic bladder cancer Publisher taylor & francis ltd

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1 results on '"Konishi, Noboru"'

1. Correlation of Immune Cells and Cytokines in the Tumor Microenvironment with Elevated Neutrophil-To-Lymphocyte Ratio in Blood: An Analysis of Muscle-Invasive Bladder Cancer.

Author

Morizawa, Yosuke, Miyake, Makito, Shimada, Keiji, Hori, Shunta, Tatsumi, Yoshihiro, Nakai, Yasushi, Onishi, Sayuri, Tanaka, Nobumichi, Konishi, Noboru, and Fujimoto, Kiyohide

Subjects
*CYTOKINES, *NEUTROPHILS, *LYMPHOCYTES, *LEUCOCYTE elastase, *BLADDER cancer, *LYMPHOCYTE metabolism, *CANCER invasiveness, *CELL lines, *CELL physiology, *ENZYME-linked immunosorbent assay, *IMMUNOPHENOTYPING, *RESEARCH methodology, *PROGNOSIS, *PROTEINS, *SMOOTH muscle, *T cells, *TISSUE culture, *PHENOTYPES, *RETROSPECTIVE studies, *CD4 lymphocyte count, BLADDER tumors
Abstract

We investigated the relationship between Neutrophil-to-lymphocyte ratio (NLR) and the quantities of neutrophil elastase, CD3, Foxp3, and CD204 in tumor-infiltrating cells and circulating cytokines (IL-2, -6, -8, 17a, and TGF-β) in muscle-invasive bladder cancer. IL-6 and IL-8 levels showed a significant correlation with NLR in blood and Foxp3+ cells around the tumor. After co-culture of peripheral blood cells with bladder cancer cell lines, the induction of regulatory T cell (Treg) was higher in T24 whose IL-6 and IL-8 levels were higher. High NLR correlates with increased IL-6 and IL-8 and Treg expression. [ABSTRACT FROM AUTHOR]

Published
2018
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