1. Congenital and proposal of a new classification for the likelihood of primary maternal infection: analysis of 375 cases in Southeast Italy.
- Author
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Vimercati, Antonella, Chincoli, Annarosa, de Gennaro, Alessandra Caterina, Calvario, Agata, Amendolara, Mariella, Del Gaudio, Giuseppe, Laforgia, Nicola, and Carbonara, Sergio
- Subjects
INFECTION ,TOXOPLASMOSIS ,AMNIOTIC liquid ,CASE studies ,CLASSIFICATION ,TOXOPLASMOSIS diagnosis ,PROTOZOA ,PARASITIC diseases in pregnancy ,PROBABILITY theory - Abstract
Objective: The aim of this study was to propose a classification in order to stratify the probability of an acute Toxoplasma infection in pregnancy and to estimate the risk of vertical transmission.Study design: We evaluated the likelihood of a primary maternal infection according to the Lebech classification and to the modified-Lebech classification proposed for our group of 375 patients referred for a suspected primary maternal infection. Fetal diagnosis included the examination of amniotic fluid by PCR to detect Toxoplasma DNA as a confirmation test.Results: Differences between the old and new classification resulted statistically significant for old classes defined as probable and unlikely with a clear shift of cases from the unlikely to the probable class in the new classification. Transmission rate showed a significant (p < .05) increase of the transmission rate in the probable class in our new classification as compared with the Lebech one.Conclusions: Results obtained in the present study suggest that the new IgG avidity-based classification herein proposed could estimate more precisely the likelihood of a primary maternal Toxoplasma infection as well as the risk of fetal infection, when compared with the historical Lebech Classification. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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