13 results on '"Anwer, Md. Khalid"'
Search Results
2. 3D printing technology in healthcare: applications, regulatory understanding, IP repository and clinical trial status.
- Author
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Kumar Gupta, Dipak, Ali, Mohd Humair, Ali, Asad, Jain, Pooja, Anwer, Md. Khalid, Iqbal, Zeenat, and Mirza, Mohd. Aamir
- Subjects
THREE-dimensional printing ,CLINICAL trials ,DRUG registration ,MEDICAL equipment ,WEB portals ,MEDICAL care - Abstract
Mass consumerization of three-dimensional (3D) printing innovation has revolutionised admittance of 3D-printing in an expansive scope of ventures. When utilised predominantly for industrial manufacturing, 3D-printing strategies have rapidly attained acquaintance in different parts of health care industry. 3D-printing is a moderately new technology that has discovered promising applications in the medication conveyance and clinical areas. This review intends to explore different parts of 3D- printing innovation concerning pharmaceutical and clinical applications. Review on pharmaceutical products like tablets, caplets, films, polypills, microdots, biodegradable patches, medical devices (uterine and subcutaneous), patient specific implants, cardiovascular stents, etc. and prosthetics/anatomical structures, surgical models, organs and tissues created utilising 3D-printing is being presented. In addition, the regulatory understanding and current IP and clinical trial status pertaining to 3D fabricated products/medical applications have also been funnelled, garnering information from different web portals of regulatory agencies and databases. It is additionally certain that for such new innovations, there would be difficulties and questions before these are acknowledged as protected and viable. The circumstance demands purposeful and wary endeavours to acquire regulations which would at last prompt the accomplishment of this progressive innovation, thus various regulatory challenges faced have been conscientiously discussed. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Development and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study.
- Author
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Zafar, Ameeduzzafar, Alruwaili, Nabil K., Imam, Syed Sarim, Alsaidan, Omar Awad, Yasir, Mohd, Ghoneim, Mohammed M., Alshehri, Sultan, Anwer, Md. Khalid, Almurshedi, Alanood S., and Alanazi, Abdullah S.
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LUTEOLIN ,CELL survival ,SURFACE morphology ,DISEASE management ,CELL lines ,CANCER cells ,ZETA potential - Abstract
The present research was aimed to develop luteolin (LL) loaded pegylated bilosomes (PG-BLs) for oral delivery. The luteolin bilosomes (BLs) were prepared by the thin-film hydration method and further optimized by the Box-Behnken design (four-factors at three-levels). The prepared LL-BLs were evaluated for vesicle size (VS), PDI, zeta potential (ZP), and entrapment efficiency to select the optimized formulation. The optimized formulation was further assessed for surface morphology, drug release, gut permeation, antioxidant, and antimicrobial study. The cytotoxicity study was conducted on breast cancer cell lines (MDA-MB-231 and MCF7). The optimized formulation LL-PG-BLs-opt exhibited a VS of 252.24± 3.54 nm, PDI of 0.24, ZP of -32mV with an encapsulation efficiency of 75.05± 0.65%. TEM study revealed spherical shape vesicles without aggregation. The DSC and XRD results revealed that LL was encapsulated into a PG-BLs matrix. LL-PG-BLs-opt exhibited a biphasic release pattern as well as significantly high permeation (p<.05) was achieved vis-a-vis LL-BL-opt and LL dispersion. The antioxidant activity result revealed 70.31± 3.22%, 83.76± 2.56%, and 96.87 ± 2.11% from LL-dispersion, LL-BLs-opt, and LL-PG-BLs-opt, respectively. Furthermore, LL-PG-BLs-opt exhibited high cell viability on both cell lines than LL-BL-opt and pure LL. The IC50 value was found to be 390 mM and 510 mM against MCF7 and MDA-MB-231 cancer cells, respectively. The antimicrobial activity result exhibited LL-PG-BLs-opt had better antibacterial activity than pure LL against Staphylococcus aureus and Escherichia coli. Hence, PG-BLs might provide an efficient nano oral delivery for the management of the different diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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4. Brigatinib loaded poly(d,l-lactide-co-glycolide) nanoparticles for improved anti-tumoral activity against non-small cell lung cancer cell lines.
- Author
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Ahmed, Mohammed Muqtader, Fatima, Farhat, Anwer, Md. Khalid, Aldawsari, Mohammed F., Bhatia, Saurabh, and Al-Harrasi, Ahmed
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NON-small-cell lung carcinoma ,CELL lines ,ERLOTINIB ,CANCER cells ,DIFFERENTIAL scanning calorimetry ,NANOPARTICLES - Abstract
The aim of the current investigation was to develop poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) to sustain the brigatinib (BTB) release for prolong time period and to examine the antitumor effect of the optimized NPs. Optimized PLGA-based NPs of BTB could be potentially used as a promising nanocarrier for the treatment of non-small cell lung cancer. BTB-loaded NPs were fabricated with core-shell of PLGA by solvent evaporation technique using different proportions of PLGA polymer and poly-vinyl alcohol (PVA) stabilizer. The prepared NPs were evaluated for particle characterizations; size, polydispersity index (PDI), zeta-potential, entrapment efficiency (EE), and drug loading (DL), Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction studies. The optimized NPs (BN5) were further evaluated for morphology, stability, and cytotoxicity studies against A549 cell-lines. Among the nine different NPs formulae (BN1–BN9), BN5 was optimized with composition of BTB (30 mg), PLGA (75 mg), PVA (0.55% w/v), represents an average particle size of (267.1 ± 1.01 nm), PDI (0.101 ± 0.007), and zeta potential (–42.1 ± 0.75 mV), high EE (66.83 ± 0.06%), and DL (6.17 ± 0.69%). SEM image of selected NPs was spherical with smooth surface. In vitro drug release profile in phosphate buffers (pH 5 and pH 7.4) showed a biphasic release with initial burst phase followed by sustained release for prolong time. Furthermore, optimized NPs (BN5) exhibited excellent cytotoxic activity against A549 cell-lines with IC
50 value of 5.25 ± 0.23 µg/mL. The overall results suggest that BTB-loaded PLGA NPs could be a potential nanocarrier for lung cancer treatment. [ABSTRACT FROM AUTHOR]- Published
- 2021
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5. Solubilization, Hansen solubility parameters, and thermodynamic studies of delafloxacin in (transcutol + 1-butyl-3-methyl imidazolium hexafluorophosphate) mixtures.
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Shakeel, Faiyaz, Anwer, Md. Khalid, Youssof, Abdullah M.E, Haq, Nazrul, Alanazi, Fars K., and Alsarra, Ibrahim A.
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SOLUBILITY ,MIXTURES ,MOLE fraction ,MOLECULAR interactions ,SOLUBILIZATION ,IONIC liquids - Abstract
The solubilization, Hansen solubility parameters (HSPs), and thermodynamic properties of delafloxacin (DLN) in various unique combination of Transcutol-HP® (THP) and 1-butyl-3-methyl imidazolium hexafluorophosphate ionic liquid (BMIM-PF
6 ) mixtures were evaluated for the first time in this research. The 'mole fraction solubilities (x3 )' of DLN in different (THP + BMIM-PF6 ) compositions were determined at 'T = 298.2–318.2 K' and 'p = 0.1 MPa'. The HSPs of DLN, neat THP, neat BMIM-PF6 , and binary (THP + BMIM-PF6 ) compositions free of DLN were also determined. The x3 data of DLN was regressed using 'van't Hoff, Apelblat, Yalkowsky-Roseman, Jouyban-Acree and Jouyban-Acree-van't Hoff models' with overall error values of less than 3.0%. The highest and lowest x3 value of DLN was recorded in neat THP (5.48 × 10−3 at T = 318.2 K) and neat BMIM-PF6 (6.50 × 10−4 at T = 298.2 K), respectively. The solubility of DLN was found to be enhanced significantly with an arise in temperature in all (THP + BMIM-PF6 ) compositions including pure THP and pure BMIM-PF6 . However, there was slight increase in DLN solubility with increase in THP mass fraction in all (THP + BMIM-PF6 ) mixtures. The HSP of pure THP and pure BMIM-PF6 were found very close to each other, suggesting the great potential of both solvents in DLN solubilization. The maximum solute-solvent interactions at molecular level were recorded in DLN-THP compared to DLN-BMIM-PF6 . An 'apparent thermodynamic analysis' study indicated an 'endothermic and entropy-driven dissolution' of DLN in all (THP + BMIM-PF6 ) compositions including neat THP and BMIM-PF6 . [ABSTRACT FROM AUTHOR]- Published
- 2021
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6. Preparation of levofloxacin loaded in situ gel for sustained ocular delivery: in vitro and ex vivo evaluations.
- Author
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Jain, Pooja, Jaiswal, Chandra Prakash, Mirza, Mohd. Aamir, Anwer, Md. Khalid, and Iqbal, Zeenat
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CONTROLLED release drugs ,EYE drops ,COLLOIDS ,TREATMENT effectiveness ,SODIUM alginate ,BORIC acid ,METHYLCELLULOSE - Abstract
The major drawback of the eye drops is rapid elimination of drug from the precorneal region, thus ensuing poor bioavailability as well as therapeutic efficacy. To conquer these limitations, a pH triggered in situ gel was developed for sustained delivery of levofloxacin. Two polymers namely hydroxypropyl methylcellulose (HPMC) and sodium alginate along with the boric acid buffer were used to formulate the in situ gel. Based on the various physicochemical evaluation parameters like pH, clarity and gelling capacity placebo formulations were selected and further characterized for viscosity, in vitro release, ex vivo corneal permeation, and histopathological studies. The optimized in situ gel (F28) showed sustained release of 93 ± 4.23% for 24 h and cumulative drug permeation of 71.81 ± 4.7% for 72 h. Additionally, ocular irritation study and histopathology of the formulation treated cornea confirm the non-irritancy of the optimized formulation. Based on all the above performed studies, it can be concluded that the in situ gel would present a fruitful alternative for the ocular infections. [ABSTRACT FROM AUTHOR]
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- 2020
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7. Co-delivery of gemcitabine and simvastatin through PLGA polymeric nanoparticles for the treatment of pancreatic cancer: in-vitro characterization, cellular uptake, and pharmacokinetic studies.
- Author
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Jamil, Adeeba, Aamir Mirza, Mohd., Anwer, Md. Khalid, Thakur, Pragya S., Alshahrani, Saad M., Alshetaili, Abdullah S., Telegaonkar, Sushama, Panda, Amulya K., and Iqbal, Zeenat
- Subjects
NANOCAPSULES ,PANCREATIC cancer treatment ,SIMVASTATIN ,NANOPARTICLES ,TRANSMISSION electron microscopy ,SCANNING electron microscopy - Abstract
Despite the ongoing extensive research, cancer therapeutics still remains an area with unmet needs which is hampered by shortfall in the development of newer medicines. The present study discusses a nano-based combinational approach for treating solid tumor. Dual-loaded nanoparticles encapsulating gemcitabine HCl (GM) and simvastatin (SV) were fabricated by double emulsion solvent evaporation method and optimized. Optimized nanoparticles showed a particle size of 258 ± 2.4 nm, polydispersity index of 0.32 ± 0.052, and zeta potential of −12.5 mV. The size and the morphology of the particles wee further confirmed by transmission electron microscopy (TEM) and scanning electron microscopy, respectively of the particles. The entrapment efficiency of GM and SV in the nanoparticles was 38.5 ± 4.5% and 72.2 ± 5.6%, respectively. The in vitro release profile was studied for 60 h and showed Higuchi release pattern. The cell toxicity was done using MTT assay and lower IC
50 was obtained with the nanoparticles as compared to the pure drug. The bioavailability of GM and SV in PLGA nanoparticles was enhanced by 1.4-fold and 1.3-fold respectively, compared to drug solution. The results revealed that co-delivery of GM and SV could be used for its oral delivery for the effective treatment of pancreatic cancer. [ABSTRACT FROM AUTHOR]- Published
- 2019
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8. Wound healing effects of nanoemulsion containing clove essential oil.
- Author
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Alam, Prawez, Ansari, Mohammad J., Anwer, Md. Khalid, Raish, Mohammad, Kamal, Yoonus K. T., and Shakeel, Faiyaz
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CLOVE (Spice) ,ESSENTIAL oils ,WOUND healing ,EMULSIONS (Pharmacy) ,MICROENCAPSULATION ,THERAPEUTICS - Abstract
The aim of this study was to investigate the wound healing effects of clove oil (CO) via its encapsulation into nanoemulsion. Optimized nanoemulsion (droplet size of 29.10 nm) was selected for wound healing investigation, collagen determination, and histopathological examination in rats. Optimized nanoemulsion presented significant would healing effects in rats as compared to pure CO. Nanoemulsion also presented significant enhancement in leucine content (0.61 mg/g) as compared to pure CO (0.50 mg/g) and negative control (0.31 mg/g). Histopathology of nanoemulsion treated rats showed no signs of inflammatory cells. These results suggested that nanoemulsion of CO was safe and nontoxic. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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9. Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats.
- Author
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Ansari, Mohammad Javed, Anwer, Md. Khalid, Jamil, Shahid, Al-Shdefat, Ramadan, Ali, Bahaa E., Ahmad, Mohammad Muqtader, and Ansari, Mohammad Nazam
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RAT diseases , *TREATMENT of diabetes , *NANOPARTICLES analysis , *BIOAVAILABILITY ,INSULIN pharmacokinetics - Abstract
Objective: Insulin is a hormone used in the treatment of diabetes mellitus. Multiple injections of insulin every day may causes pain, allergic reactions at injection site, which lead to low patient compliance. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral delivery of insulin. Methods: SLNs were prepared by double emulsion solvent evaporation (w/o/w) technique, employing glyceryltrimyristate (Dynasan 114) as lipid phase and soy lecithin and polyvinyl alcohol as primary and secondary emulsifier, respectively, and evaluatedin vitrofor particle size, polydispersity index (PDI) and drug entrapment. Results: Among the eight different developed formulae (F1–F8), F7 showed an average particle size (99 nm), PDI (0.021), high entrapment of drug (56.5%). The optimized formulation (F7) was further evaluated by FT-IR, DSC, XRD,in vitrorelease, permeation, stability, bioavailability and pharmacological studies. Insulin-loaded SLNs showed better protection from gastrointestinal environment as evident from the relative bioavailability, which was enhanced five times as compared to the insulin solution. A significant enhancement of relative bioavailability of insulin was observed, i.e. approximately five times of pure insulin solution when loaded in SLN (8.26% versus 1.7% only). [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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10. Dissolution thermodynamics and solubility of silymarin in PEG 400-water mixtures at different temperatures.
- Author
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Shakeel, Faiyaz and Anwer, Md Khalid
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DISSOLUTION (Chemistry) ,THERMODYNAMICS ,SILYMARIN ,DRUG solubility ,SOLVENTS ,POLYETHYLENE glycol ,THERAPEUTICS - Abstract
An isothermal method was used to measure the solubility of silymarin in binary polyethylene glycol 400 (PEG 400) + water co-solvent mixtures at temperaturesT = 298.15–333.15 K and pressurep = 0.1 MPa. Apelblat and Yalkowsky models were used to correlate experimental solubility data. The mole fraction solubility of silymarin was found to increase with increasing the temperature and mass fraction of PEG 400 in co-solvent mixtures. The root mean square deviations were observed in the range of 0.48–5.32% and 1.50–9.65% for the Apelblat equation and Yalkowsky model, respectively. The highest and lowest mole fraction solubility of silymarin was observed in pure PEG 400 (0.243 at 298.15 K) and water (1.46 × 10−5at 298.15 K). Finally, thermodynamic parameters were determined by Van’t Hoff and Krug analysis, which indicated an endothermic and spontaneous dissolution of silymarin in all co-solvent mixtures. [ABSTRACT FROM AUTHOR]
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- 2015
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11. Niosomes in sustained and targeted drug delivery: some recent advances.
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Azeem, Adnan, Anwer, Md. Khalid, and Talegaonkar, Sushama
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SURFACE active agents , *LIPOSOMES , *COSMETICS industry , *INDUSTRIAL applications , *DRUG delivery systems , *BIOTECHNOLOGY , *TARGETED drug delivery - Abstract
Niosomes represent an emerging class of novel vesicular systems. They are composed of nonionic surfactants which are biodegradable and relatively nontoxic. They were developed as stable and inexpensive alternatives to liposomes. Since their early introduction to cosmetic industry their role has diversified to other application areas. They are now being ardently explored as potential carriers for sustained and targeted drug delivery. In addition to conventional, oral, and parenteral routes, they are amenable to be delivered by ocular, transdermal, vaginal, and inhalation routes. Delivery of biotechnological products including vaccine delivery with niosomes is also an interesting and promising research area. The introduction of provesicular approach in the form of proniosomes has further increased the relevance of these systems. More concerted research efforts, however, are still required to realize the full potential of these novel systems. This review considers the current status and explores the potential of niosomes in drug delivery with special attention to their role in drug targeting. Their methods of preparation, formulation aspects, advantages, limitations, and applications are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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12. Proniosomal transdermal therapeutic system of losartan potassium: development and pharmacokinetic evaluation.
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Thakur, Reena, Anwer, Md Khalid, Shams, Mohammad S., Ali, Asgar, Khar, Roop K., Shakeel, Faiyaz, and Taha, Ehab I.
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POTASSIUM , *TRANSDERMAL medication , *PHARMACOKINETICS , *BIOAVAILABILITY ,PERMEABILITY of solids - Abstract
The purpose of the current study was to investigate the feasibility of proniosomes as transdermal drug delivery system for losartan potassium. Different preparations of proniosomes were fabricated using different nonionic surfactants, such as Span 20, Span 40, Span 60, Span 80, Tween 20, Tween 40, and Tween 80. Different formulae were prepared and coded as PNG-1 (proniosomal gel-1) to PNG-7. The best in vitro skin permeation profile was obtained with proniosomal formulation PNG-2 in 24 h. The permeability parameters such as flux, permeability coefficient, and enhancement ratio were significant for PNG-2 compared with other formulations ( P < 0.05). This optimized PNG-2 was fabricated in the form of transdermal patch using HPMC gel as a suitable base. Proniosomal transdermal therapeutic system (PNP-H) was found to be the optimized one as it gave better release of drug and better permeation in a steady-state manner over a desired period of time, that is, 24 h through rat skin. In vivo pharmacokinetic study of PNP-H showed a significant increase in bioavailability (1.93 times) compared with oral formulation of losartan potassium. The formulation appeared to be stable when stored at room temperature (30 ± 2°C) and at refrigeration temperature (4 ± 2°C) for 45 days. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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13. Preparation, in vitro and in vivo evaluation of solid-state self-nanoemulsifying drug delivery system (SNEDDS) of vitamin A acetate.
- Author
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Taha, Ehab I, Al-Suwayeh, Saleh A., and Anwer, Md. Khalid
- Subjects
DRUG delivery systems ,VITAMIN A ,EMULSIONS (Pharmacy) ,FAT-soluble vitamins ,RETINOIDS - Abstract
Vitamin A self-nanoemulsifying drug delivery system (SNEDDS), which comprises soybean oil, Cremophor EL, and Capmul MCM-C8, was prepared and mixed with different grades of Avicel to produce homogenized powders. The resultant powders were compressed into tablets. The prepared tablets were characterized for their thickness, hardness, friability, disintegration time, and dissolution rate. In addition, the relative bioavailability of the tablets in comparison to solid-state Vitamin A oily solution (SSVAOS) tablets was investigated in rats. Vitamin A dissolution rate was markedly different from one formulation to another. From the bioavailability data, it was observed that Vitamin A SNEDD tablets have higher bioavailability (relative bioavailability 143.68%) compared with SSVAOS tablets. The AUC and C
max of Vitamin A SNEDD tablets were found to be significantly different from that of SSVAOS tablets. [ABSTRACT FROM AUTHOR]- Published
- 2009
- Full Text
- View/download PDF
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