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As the economy has globalized, it has also regionalized, which has led to the integration of different spaces across different scales. A number of theories contend that the endogenous assets of these locations provide them with the means to compete in this globalizing economy, especially in relation to knowledge- based sectors like biotechnology. Among these theories, the cluster concept stands out. However, there is little support for the arguments that local linkages are the central contributors to innovation. Extralocal linkages have also been highlighted, suggesting that other theories that account for these linkages may prove useful in the discussion of knowledge-based sectors, in general, and biotechnology, in particular. One such theory is the concept of global commodity chains, which explicitly concerns the interconnections within and across different geographic scales. As yet it has seldom been applied to the biotechnology industry. This article uses the approach to explore the U.K. biotechnology industry. [ABSTRACT FROM AUTHOR]