1. Anti-inflammatory constituents from Psychotria prainii H. Lév.
- Author
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Tran PH, Le VD, Do TH, Nguyen TL, Nguyen PT, Nguyen TT, and Nguyen TD
- Subjects
- Animals, Anti-Inflammatory Agents isolation & purification, Carbamates isolation & purification, Cyclopentane Monoterpenes, Glucosides, Glycosides isolation & purification, Mice, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Components, Aerial chemistry, Plant Extracts chemistry, Pyrans, RAW 264.7 Cells, Vietnam, Anti-Inflammatory Agents pharmacology, Carbamates pharmacology, Glycosides pharmacology, Psychotria chemistry
- Abstract
One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC
50 values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii.- Published
- 2019
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