1. A new sesquiterpene lactone from yacon leaves.
- Author
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Yuan Y, Win Aung KK, Ran XK, Wang XT, Dou DQ, and Dong F
- Subjects
- Antineoplastic Agents, Phytogenic pharmacology, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Lactones chemistry, Magnetic Resonance Spectroscopy, Mass Spectrometry, Plant Extracts chemistry, Plant Extracts pharmacology, Asteraceae chemistry, Plant Leaves chemistry, Sesquiterpenes chemistry
- Abstract
The chemical constituents of 60% EtOH extract of yacon leaves were separated to yield a new compound, together with four known compounds, which were isolated for the first time from yacon. The new compound was characterised and named as chlorodalin (1) on the basis of NMR (1D and 2D), HR-MS and other spectral methods. The cytotoxic activities of 1-5 were evaluated on two human tumour cell lines and the new compound showed significant cytotoxic activity.
- Published
- 2017
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