1. Comprehensive metabolite profiling in distinct chemotypes of Commiphora wightii.
- Author
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Bhatia A, Tripathi T, Singh S, Bisht H, Behl HM, Roy R, and Sidhu OP
- Subjects
- Chromatography, High Pressure Liquid, Citric Acid metabolism, Commiphora metabolism, Dietary Supplements, Gas Chromatography-Mass Spectrometry, Inositol metabolism, Magnetic Resonance Spectroscopy, Quinic Acid metabolism, Commiphora chemistry, Metabolomics methods, Plant Extracts chemistry, Plant Gums chemistry, Plant Leaves metabolism
- Abstract
Commiphora wightii (Arn.) Bhandari, known as guggul, produces a medicinally important gum resin which is used extensively by Ayurvedic physicians to treat various ailments. However, most of the studies on C. wightii have been limited to its gum resin. Comprehensive metabolic profiling of leaves, stem and gum resin samples was undertaken to analyse aqueous and non-aqueous metabolites from three distinct chemotypes (NBRI-101, NBRI-102 and NBRI-103) shortlisted from different agro-climatic zones. GC-MS, HPLC and NMR spectroscopy were used for comprehensive metabolomics. Multivariate analysis showed characteristic variation in quinic and citric acids, myo-inositol and glycine (aqueous metabolites) and 2,6-di-tert-butyl-phenol, trans-farnesol and guggulsterones (non-aqueous metabolites) amongst the three chemotypes. Quinic acid, citric acid and myo-ionositol were detected in substantial quantities from leaves and stem samples which provide opportunities for novel nutraceutical and pharmaceutical formulations. Quinic acid, from the leaves, was identified as a marker metabolite for early selection of high guggulsterones-yielding cultivars.
- Published
- 2019
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