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Skin wounds are the most prevalent daily affections intruding fishes in an aquaculture facility. Such skin affections are considered to be the most common portals of entry for disease agents affecting fishes. This persistent phenomenon necessitates a comprehensive search for an efficient healing therapy to combat the ongoing dermal damage and its pathological consequences. In the current study, the core hypothesis has been vigorously tested through the experimental application of hemodialysate (Solcoseryl®) solution in several exposure methods including bath, intraperitoneal (I.P.), intramuscular (I.M.), and local infiltration routes. All tested routes were capable of inducing different degrees of healing in Nile tilapia (Oreochromis niloticus). The core hypothesis of the current research has been experimentally accomplished through assessing the resultant healing degrees based on both gross as well as tissue alteration dynamics among total of 5 experimental groups. Each group consisted of 10 fishes/aquarium. The swift tissue healing of the induced wounds in Nile tilapia were completely achieved 4 days post I.M. injection of the Solcoseryl® solution (10 μl/50 g fish as a single dose) with an excellent healing grade (+++++). However, bath treatment (1 ml/Lwater as a single dose) and local infiltration (10 μl/50 g fish as a single dose) have proved to be second on the race (complete healing was achieved 6 days post treatment with very good grade (+++)). This study demonstrates the clinical value of fish models in establishment of new approach for combating prevalent invasive skin affections in aquaculture.