1. T-cell redirecting bispecific antibody treatment in multiple myeloma: current knowledge and future strategies for sustained T-cell engagement.
- Author
-
Heerma van Voss MR, Molenaar RJ, Korst CLBM, Bartelink IH, Baglio SR, Kruyswijk S, de Ruijter M, Zweegman S, Kuipers MT, and van de Donk NWCJ
- Subjects
- Humans, Animals, B-Cell Maturation Antigen immunology, B-Cell Maturation Antigen antagonists & inhibitors, Antibodies, Bispecific pharmacokinetics, Antibodies, Bispecific therapeutic use, Antibodies, Bispecific administration & dosage, Antibodies, Bispecific immunology, Multiple Myeloma immunology, Multiple Myeloma drug therapy, Multiple Myeloma therapy, T-Lymphocytes immunology, T-Lymphocytes drug effects
- Abstract
Introduction: T-cell redirecting bispecific antibodies (BsAbs), targeting B-cell maturation antigen (BCMA) or G-protein - coupled receptor class C group 5 member D (GPRC5D), are efficacious new agents for the treatment of patients with relapsed or refractory MM., Areas Covered: This review discusses the pharmacokinetic properties, efficacy, and safety profile of T-cell redirecting BsAbs in MM, with a special focus on their optimal dosing schedule, resistance mechanisms and future strategies to enhance efficacy, reduce toxicity, and maximize duration of response., Expert Opinion: To further improve the efficacy of BsAbs, ongoing studies are investigating whether combination therapy can enhance depth and duration of response. An important open question is also to what extent response to BsAbs can be improved when these agents are used in earlier lines of therapy. In addition, more evidence is needed on rational de-intensification strategies of BsAb dosing upon achieving a sufficient response, and if (temporary) treatment cessation is possible in patients who have achieved a deep remission (e.g. complete response or minimal residual disease-negative status).
- Published
- 2024
- Full Text
- View/download PDF