1. Steroidal saponins from the rhizome of Polygonatum sibiricum
- Author
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Ya-Ming Yu, Cheng Tang, Jia Wang, Sheng-An Tang, Qing-Ling Qi, and Xiao-Dan Wu
- Subjects
Pharmacology ,Polygonatum sibiricum ,Molecular Structure ,Traditional medicine ,010405 organic chemistry ,Chemistry ,Polygonatum ,Organic Chemistry ,Phytosterols ,Pharmaceutical Science ,General Medicine ,Saponins ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,Rhizome ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Drug Discovery ,Molecular Medicine ,Nuclear Magnetic Resonance, Biomolecular - Abstract
Four new steroidal saponins, 3-O-β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl -(25R)-spirost-5-en-3β,17α-diol (1), 3-O-β-D-glucopyranosyl(1→4)-β-D- fucopyranosyl-(25S)-spirost-5-en-3β,17α-diol (2), 3-O-β-D-glucopyranosyl(1→2) -β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl-(25R)-spirost-5-en-3β,17α-diol (3), 3-O-β-D-glucopyranosyl(1→4)-β-D-fucopyranosyl-(25R/S)-spirost-5-en-3β,12β-diol (4), together with five known steroidal saponins were isolated from the ethanolic extract of the rhizome of Polygonatum sibiricum. Chemical structures of these compounds were elucidated by spectroscopic techniques. Anti-inflammatory activities of these new compounds were evaluated.
- Published
- 2018
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