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3. Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

Author

Rumpf C, Cipak L, Dudas A, Benko Z, Pozgajova M, Riedel CG, Ammerer G, Mechtler K, and Gregan J

Subjects
Anaphase, Chromosomes, Fungal metabolism, Mass Spectrometry, Phosphoproteins chemistry, Phosphorylation, Protein Transport, Schizosaccharomyces pombe Proteins chemistry, Subcellular Fractions metabolism, Meiosis, Phosphoproteins metabolism, Protein Kinases metabolism, Schizosaccharomyces cytology, Schizosaccharomyces enzymology, Schizosaccharomyces pombe Proteins metabolism
Abstract

Segregation of chromosomes during meiosis depends on separase cleavage of Rec8, the meiosis-specific alpha-kleisin subunit of cohesin. We mapped Rec8 phosphorylation sites by mass spectrometry and show that Rec8 phosphorylation is required for proper chromosome disjunction during meiosis. We further show that the fission yeast casein kinase 1 (CK1) delta/epsilon isoforms Hhp1 and Hhp2 are required for full levels of Rec8 phosphorylation and for efficient removal of Rec8 at the onset of anaphase I. Our data are consistent with the model that Hhp1/Hhp2-dependent phosphorylation of Rec8 is required for separase-mediated cleavage of Rec8 during meiosis I., (© 2010 Landes Bioscience)

Published
2010
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