1. Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
- Author
-
Phongphan Jantaharn, Sarawut Tontapha, Sirirath McCloskey, Nuttika Suwannasai, Vittaya Amornkitbumrung, Praewpan Katrun, Wiyada Mongkolthanaruk, Theerawat Patjana, and Thanaset Senawong
- Subjects
biology ,010405 organic chemistry ,medicine.drug_class ,Organic Chemistry ,Xylaria ,Plant Science ,Fungus ,Isolation (microbiology) ,biology.organism_classification ,Xylaria sp ,01 natural sciences ,Biochemistry ,Anti-inflammatory ,0104 chemical sciences ,Analytical Chemistry ,Microbiology ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Chromone ,Mellein ,medicine ,Cytotoxicity - Abstract
The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL).
- Published
- 2019
- Full Text
- View/download PDF